ACAN and MMP20

Number of citations of the paper that reports this interaction (PMID 10922468)
18

Data Source:
HPRD (in vitro)

		ACAN	MMP20
Gene Name		aggrecan	matrix metallopeptidase 20
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Extracellular Matrix Lysosomal Lumen	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Carbohydrate Binding Metal Ion Binding	Metalloendopeptidase Activity Calcium Ion Binding Protein Binding Zinc Ion Binding
	Biological Process	Skeletal System Development Carbohydrate Metabolic Process Proteolysis Cell Adhesion Pathogenesis Keratan Sulfate Biosynthetic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Small Molecule Metabolic Process	Proteolysis Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Collagen Catabolic Process Regulation Of Enamel Mineralization Amelogenesis
Pathways			Collagen formation Collagen degradation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		Height ( 21998595 20881960 23563607 18391952)	Prostate cancer ( 23535732)
Protein-Protein Interactions		18 interactors: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 TNFAIP6 TNR VCAN	1 interactors: ACAN
Entrez ID		176	9313
HPRD ID		01123	05218
Ensembl ID		ENSG00000157766	ENSG00000137674
Uniprot IDs		E7ENV9 E7EX88	O60882
PDB IDs			2JSD
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Proteolysis Catabolic Process Ovulation Skeletal System Development Multicellular Organismal Development Endodermal Cell Differentiation Endoderm Formation Developmental Process Single Organism Reproductive Process Reproductive Process Anatomical Structure Development Ovulation From Ovarian Follicle Endoderm Development System Development Ovulation Cycle Process Female Gonad Development Female Gamete Generation Ovulation Cycle Development Of Primary Female Sexual Characteristics Positive Regulation Of Protein Oligomerization Protein Metabolic Process Organ Development Formation Of Primary Germ Layer Regulation Of Protein Oligomerization Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Cardiovascular System Development Response To Stress Gastrulation Reproductive Structure Development Reproductive System Development Trabecula Morphogenesis Female Pregnancy Gonad Development Development Of Primary Sexual Characteristics Reproduction Negative Regulation Of Axon Extension Involved In Regeneration Anatomical Structure Formation Involved In Morphogenesis Glycosaminoglycan Catabolic Process Cellular Response To Amino Acid Stimulus Response To Stimulus Glial Cell Migration Ossification	Keratan Sulfate Catabolic Process Keratan Sulfate Biosynthetic Process Cartilage Condensation Keratan Sulfate Metabolic Process Chondrocyte Development Glycosaminoglycan Catabolic Process Proteoglycan Biosynthetic Process Collagen Fibril Organization Chondrocyte Differentiation Extracellular Matrix Disassembly Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Glycosaminoglycan Metabolic Process Cartilage Development Pathogenesis Connective Tissue Development Skeletal System Morphogenesis Sulfur Compound Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Glycoprotein Biosynthetic Process Glycoprotein Metabolic Process
Tagcloud ?		acoustic bioreactor biot bm butanol chitosan chondrocyte col1a1 col2a1 connected cs csb impacted kpa mathematical mhz paralleled polycarbonate polyurethane porosities propagation scaffold scaffolds seeded served simplified sox supplied us	ameloblasts amelogenin amelogenins amorphous catalyzes cleavage cleavages cleaves comprise deglycosylated doesn enamel enamelin generates glycosylated hydroxyapatite kda lrap p132 p148 p162 p173 p190 p56 p62 thicken trp unless widen
Tagcloud (Difference) ?		acoustic bioreactor biot bm butanol chitosan chondrocyte col1a1 col2a1 connected cs csb impacted kpa mathematical mhz paralleled polycarbonate polyurethane porosities propagation scaffold scaffolds seeded served simplified sox supplied us	ameloblasts amelogenin amelogenins amorphous catalyzes cleavage cleavages cleaves comprise deglycosylated doesn enamel enamelin generates glycosylated hydroxyapatite kda lrap p132 p148 p162 p173 p190 p56 p62 thicken trp unless widen
Tagcloud (Intersection) ?