Wiki-Pi
About
Search
People
Updates
Search
ACAN
Description
aggrecan
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Golgi Lumen
Extracellular Matrix
Lysosomal Lumen
Synapse
Perineuronal Net
Molecular Function
Extracellular Matrix Structural Constituent
Protein Binding
Hyaluronic Acid Binding
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Carbohydrate Binding
Metal Ion Binding
Biological Process
Skeletal System Development
Proteolysis
Cell Adhesion
Central Nervous System Development
Pathways
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Keratan sulfate biosynthesis
Keratan sulfate degradation
ECM proteoglycans
Defective CHST6 causes MCDC1
Defective ST3GAL3 causes MCT12 and EIEE15
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs
Ilomastat
Diseases
Familial osteochondritis dissecans; Osteochondritis dissecans, short stature, and early-onset osteoarthritis
Spondyloepiphyseal dysplasia, Kimberley type
GWAS
Age-related hearing impairment (
27764096
)
Appendicular lean mass (
33097823
)
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Body size at age 10 (
32376654
)
Dupuytren's disease (
28886342
)
Height (
20881960
31562340
28552196
33713608
18391952
28270201
25429064
25282103
25133637
23563607
21998595
)
Hip circumference adjusted for BMI (
34021172
25673412
)
Infant length (
25281659
)
Waist circumference adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) (
28448500
)
Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) (
28443625
)
Waist circumference adjusted for BMI in active individuals (
28448500
)
Waist circumference adjusted for BMI in non-smokers (
28443625
)
Waist circumference adjusted for body mass index (
28448500
25673412
34021172
)
Novel Interacting Genes
5 novel interacting genes:
BLM
IDH2
MAN2A2
SLCO3A1
STARD5
Interacting Genes
18 interacting genes:
ADAMTS1
ADAMTS4
ADAMTS5
CTSB
FBLN1
FBLN2
HAPLN1
LUM
MMP1
MMP14
MMP19
MMP2
MMP20
MMP3
MMP8
PTPRF
TNFAIP6
TNR
Entrez ID
176
HPRD ID
01123
Ensembl ID
ENSG00000157766
Uniprot IDs
A0A5K1VW97
P16112
PDB IDs
4MD4
7RDV
Enriched GO Terms of Interacting Partners
?
Extracellular Matrix
Extracellular Matrix Organization
Extracellular Structure Organization
Extracellular Matrix Disassembly
Metalloendopeptidase Activity
Collagen Catabolic Process
Metallopeptidase Activity
Collagen Metabolic Process
Endopeptidase Activity
Peptidase Activity
Hydrolase Activity
Extracellular Region
Extracellular Space
Serine-type Endopeptidase Activity
Proteolysis
Cellular Response To UV-A
Ovulation From Ovarian Follicle
Ovulation Cycle Process
Response To UV-A
Ovulation
Protein Metabolic Process
Fibronectin Binding
Zinc Ion Binding
Endodermal Cell Differentiation
Regulation Of Cell Migration
Ovarian Follicle Development
Regulation Of Cell Motility
Metal Ion Binding
Macromolecule Metabolic Process
Regulation Of Locomotion
Cellular Response To Radiation
Perineuronal Net
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Cellular Response To UV
Rhythmic Process
Cellular Response To Light Stimulus
Hyaluronic Acid Binding
Extracellular Matrix Structural Constituent
Catabolic Process
Anatomical Structure Formation Involved In Morphogenesis
Neuron Projection Regeneration
Regulation Of Axon Regeneration
Negative Regulation Of Multicellular Organismal Process
Regulation Of Multicellular Organismal Process
Negative Regulation Of Cell Adhesion
Regulation Of Neuron Projection Regeneration
Extracellular Matrix Binding
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Tagcloud
?