IDH2 and PYGL

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		IDH2	PYGL
Name		isocitrate dehydrogenase (NADP(+)) 2	glycogen phosphorylase L
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Peroxisome Cytosol Extracellular Exosome	Extracellular Region Cytoplasm Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Metal Ion Binding NAD Binding	Nucleotide Binding Purine Nucleobase Binding Catalytic Activity 1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding ATP Binding D-glucose Binding Glycogen Phosphorylase Activity AMP Binding Transferase Activity Glycosyltransferase Activity Vitamin Binding Pyridoxal Phosphate Binding Bile Acid Binding Identical Protein Binding
	Biological Process	Carbohydrate Metabolic Process Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process NADP+ Metabolic Process NADP+ Biosynthetic Process Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Glial Cell Migration Negative Regulation Of Matrix Metallopeptidase Secretion	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Catabolic Process Response To Bacterium Glucose Homeostasis Necroptotic Process
Pathways		Transcriptional activation of mitochondrial biogenesis Citric acid cycle (TCA cycle) Mitochondrial protein degradation Maturation of TCA enzymes and regulation of TCA cycle	Neutrophil degranulation Glycogen breakdown (glycogenolysis)
Drugs		Isocitric Acid Enasidenib	None
Diseases		None	Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Cerebrospinal fluid clusterin levels ( 26545630 ) Gout ( 33832965 ) Pulse pressure ( 27841878 30578418 ) Urate levels ( 31578528 )	Acute lymphoblastic leukemia (childhood) ( 23007406 ) Blood protein levels ( 30072576 ) Psychosis (atypical) ( 24132900 ) Rectal cancer ( 33632709 )
Novel Interactors		3 novel interactors: ACAN FURIN GPX1	1 novel interactors: POLE2
Interacting Genes		5 interacting genes: CDK1 FBXO7 PLK1 PYGL SLC2A4	7 interacting genes: BAG1 CEBPA HSD17B10 HSD3B7 IDH2 PYGB PYGM
Entrez ID		3418	5836
HPRD ID		00973	01987
Ensembl ID		ENSG00000182054	ENSG00000100504
Uniprot IDs		B4DSZ6 P48735	P06737
PDB IDs		4JA8 5GIS 5I95 5I96 5SVN 5SVO 6ADI 6UJ7 6UJ8 6UJ9 6VFZ	1EM6 1EXV 1FA9 1FC0 1L5Q 1L5R 1L5S 1L7X 1XOI 2ATI 2QLL 2ZB2 3CEH 3CEJ 3CEM 3DD1 3DDS 3DDW 8EMS
GO Terms Enriched among Interactors		Mitotic Nuclear Membrane Disassembly Membrane Disassembly Nuclear Membrane Disassembly Trans-Golgi Network Transport Vesicle Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Protein Localization To Site Of Double-strand Break Carbohydrate Homeostasis Glucose Homeostasis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cell Cycle Phase Transition Chromosome Condensation Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle G2/M Phase Transition Pronuclear Fusion Negative Regulation Of Apoptotic Process Cellular Response To Chemical Stress Spindle Microtubule Nuclear Membrane Organization Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Fibroblast Proliferation Mitotic DNA Integrity Checkpoint Signaling Striated Muscle Cell Development Centrosome Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Negative Regulation Of Programmed Cell Death G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Signaling Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Protein Catabolic Process Regulation Of Proteolysis Macromolecule Metabolic Process Golgi Lumen Mitotic DNA-templated DNA Replication Muscle Cell Development	Glycogen Phosphorylase Activity 1,4-alpha-oligoglucan Phosphorylase Activity Bile Acid Biosynthetic Process Polysaccharide Catabolic Process Glycogen Catabolic Process Bile Acid Metabolic Process Steroid Metabolic Process Generation Of Precursor Metabolites And Energy RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Pyridoxal Phosphate Binding Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase Activity Carbohydrate Metabolic Process Response To Vitamin B2 C/EBP Complex 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Glyoxylate Cycle Isocitrate Dehydrogenase (NADP+) Activity Monocarboxylic Acid Metabolic Process CHOP-C/EBP Complex Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Carbohydrate Catabolic Process 3-beta-hydroxy-Delta5-steroid Dehydrogenase (NAD+) Activity Oxidoreductase Activity White Fat Cell Proliferation Mitochondrial RNA 5'-end Processing Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Isoleucine Metabolic Process L-isoleucine Catabolic Process Isocitrate Metabolic Process Epsilon DNA Polymerase Complex B Cell Chemotaxis Small Molecule Metabolic Process TRNA Methyltransferase Complex Mitochondrial RNA 3'-end Processing Testosterone Dehydrogenase (NAD+) Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity