ACAN and STARD5

Data Source: HiPPIP (Novel)

		ACAN	STARD5
Name		aggrecan	StAR related lipid transfer domain containing 5
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Synapse Perineuronal Net	Cytosol
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding Metal Ion Binding	Lipid Binding Cholesterol Binding Cholesterol Transfer Activity
	Biological Process	Skeletal System Development Proteolysis Cell Adhesion Central Nervous System Development	Lipid Transport Cholesterol Import
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	Recycling of bile acids and salts
Drugs		Ilomastat	None
Diseases		Familial osteochondritis dissecans; Osteochondritis dissecans, short stature, and early-onset osteoarthritis Spondyloepiphyseal dysplasia, Kimberley type	None
GWAS		Age-related hearing impairment ( 27764096 ) Appendicular lean mass ( 33097823 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Body size at age 10 ( 32376654 ) Dupuytren's disease ( 28886342 ) Height ( 20881960 31562340 28552196 33713608 18391952 28270201 25429064 25282103 25133637 23563607 21998595 ) Hip circumference adjusted for BMI ( 34021172 25673412 ) Infant length ( 25281659 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172 )	No GWAS studies recorded
Novel Interactors		5 novel interactors: BLM IDH2 MAN2A2 SLCO3A1 STARD5	2 novel interactors: ACAN FES
Interacting Genes		18 interacting genes: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 PTPRF TNFAIP6 TNR	1 interacting genes: PRNP
Entrez ID		176	80765
HPRD ID		01123	09517
Ensembl ID		ENSG00000157766	ENSG00000172345
Uniprot IDs		A0A5K1VW97 P16112	Q9NSY2
PDB IDs		4MD4 7RDV	2R55
GO Terms Enriched among Interactors		Extracellular Matrix Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Metalloendopeptidase Activity Collagen Catabolic Process Metallopeptidase Activity Collagen Metabolic Process Endopeptidase Activity Peptidase Activity Hydrolase Activity Extracellular Region Extracellular Space Serine-type Endopeptidase Activity Proteolysis Cellular Response To UV-A Ovulation From Ovarian Follicle Ovulation Cycle Process Response To UV-A Ovulation Protein Metabolic Process Fibronectin Binding Zinc Ion Binding Endodermal Cell Differentiation Regulation Of Cell Migration Ovarian Follicle Development Regulation Of Cell Motility Metal Ion Binding Macromolecule Metabolic Process Regulation Of Locomotion Cellular Response To Radiation Perineuronal Net Extracellular Matrix Structural Constituent Conferring Compression Resistance Cellular Response To UV Rhythmic Process Cellular Response To Light Stimulus Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Neuron Projection Regeneration Regulation Of Axon Regeneration Negative Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Adhesion Regulation Of Neuron Projection Regeneration Extracellular Matrix Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion	Extracellular Matrix Structural Constituent Conferring Compression Resistance Hyaluronic Acid Binding Perineuronal Net Immunoglobulin Receptor Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Myoblast Proliferation Cellular Response To Vitamin D Positive Regulation Of Monocyte Differentiation Microtubule Binding Regulation Of Monocyte Differentiation Regulation Of Cell Projection Organization ATP-dependent Protein Binding Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Glutamate Receptor Signaling Pathway Inclusion Body Regulation Of Calcium Ion Import Across Plasma Membrane Neuron Projection Maintenance Negative Regulation Of Interleukin-17 Production Negative Regulation Of Dendritic Spine Maintenance Regulation Of Dendritic Spine Maintenance Glycosaminoglycan Binding Extrinsic Component Of Membrane Negative Regulation Of Long-term Synaptic Potentiation Aspartic-type Endopeptidase Inhibitor Activity Intracellular Copper Ion Homeostasis Negative Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Targeting To Membrane Dendritic Spine Maintenance Type 8 Metabotropic Glutamate Receptor Binding Negative Regulation Of Amyloid-beta Formation Molecular Function Activator Activity Cuprous Ion Binding Cupric Ion Binding Regulation Of Glutamate Receptor Signaling Pathway Copper Ion Homeostasis Negative Regulation Of Interleukin-2 Production Cellular Response To Copper Ion Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Negative Regulation Of Activated T Cell Proliferation Lamin Binding Type 5 Metabotropic Glutamate Receptor Binding Cell Adhesion Cardiac Muscle Cell Proliferation Regulation Of Cell Adhesion Positive Regulation Of Microtubule Polymerization Response To Vitamin D Cellular Response To Nutrient Cellular Response To Oxygen-containing Compound Non-membrane Spanning Protein Tyrosine Kinase Activity