DLX5 and SPEN

Number of citations of the paper that reports this interaction (PubMedID 10451362)
0

Data Source:
HPRD (in vitro)

		DLX5	SPEN
Description		distal-less homeobox 5	spen family transcriptional repressor
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GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Nucleus Nucleoplasm Transcription Repressor Complex Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	Nucleic Acid Binding DNA Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Skeletal System Development Ossification Osteoblast Differentiation Endochondral Ossification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Axonogenesis Axon Guidance Cell Population Proliferation Positive Regulation Of Gene Expression Olfactory Bulb Interneuron Differentiation Cell Differentiation Embryonic Limb Morphogenesis BMP Signaling Pathway Epithelial Cell Differentiation Inner Ear Morphogenesis Ear Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Embryonic Skeletal System Development Positive Regulation Of Epithelial Cell Proliferation Roof Of Mouth Development Olfactory Pit Development Head Development Face Morphogenesis Bone Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Interneuron Axon Guidance	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Regulatory NcRNA-mediated Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Neurogenesis Random Inactivation Of X Chromosome
Pathways		Regulation of RUNX2 expression and activity Specification of the neural plate border Developmental Lineage of Mammary Stem Cells	RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS		Heel bone mineral density ( 28869591 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Morning vs. evening chronotype ( 26835600)	Erectile dysfunction ( 30583798) Heel bone mineral density ( 28869591) Hemoglobin levels ( 32327693)
Interacting Genes		9 interacting genes: DLX2 HOXC8 MAGED1 MSX1 MSX2 NCOA2 SOX10 SOX8 SPEN	24 interacting genes: ATXN1 CLK1 CRK CTBP1 DLX5 HDAC1 HDAC2 ITCH MBD3 MSX2 MTA2 NCOR1 NCOR2 PPARD RARA RBBP4 RBPJ RIDA RUNX1 RUNX1T1 SERTAD1 SOX9 SRPK2 UBE2L6
Entrez ID		1749	23013
HPRD ID		02492	10230
Ensembl ID		ENSG00000105880	ENSG00000065526
Uniprot IDs		P56178 Q53Y73	Q96T58
PDB IDs		2DJN 4RDU	1OW1 2RT5 4P6Q 7Z1K
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Developmental Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Mesenchymal Cell Apoptotic Process Morphogenesis Of A Branching Structure Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process Oligodendrocyte Differentiation Embryonic Nail Plate Morphogenesis Cell Surface Receptor Signaling Pathway Involved In Heart Development Positive Regulation Of Multicellular Organismal Process Activation Of Meiosis Animal Organ Morphogenesis Negative Regulation Of Photoreceptor Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Regulation Of Multicellular Organismal Process Transcription Cis-regulatory Region Binding Regionalization Regulation Of Gene Expression Regulation Of Animal Organ Morphogenesis Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Differentiation DNA Binding Regulation Of Primary Metabolic Process Mammary Gland Epithelium Development Odontogenesis Mesenchymal Cell Apoptotic Process Enteric Nervous System Development Regulation Of Gliogenesis Cartilage Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Glial Cell Differentiation Regulation Of Multicellular Organismal Development RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Stem Cell Differentiation Regulation Of Neurogenesis	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Stem Cell Differentiation NuRD Complex Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of MiRNA Transcription Regulation Of Cell Population Proliferation Histone Deacetylase Binding Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Protein-containing Complex Regulation Of Cell Differentiation Nucleosomal DNA Binding Histone Deacetylase Complex DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Fate Commitment Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Binding Positive Regulation Of Macromolecule Metabolic Process Transcription Repressor Complex Transcription Cis-regulatory Region Binding Regulation Of Developmental Process Regulation Of MiRNA Transcription Nucleoplasm DNA Binding Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of Cell Population Proliferation RNA Polymerase II-specific DNA-binding Transcription Factor Binding
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