DLX5 and SOX8

Number of citations of the paper that reports this interaction (PubMedID 16582099)
44

Data Source:
HPRD (two hybrid)

		DLX5	SOX8
Description		distal-less homeobox 5	SRY-box transcription factor 8
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Skeletal System Development Ossification Osteoblast Differentiation Endochondral Ossification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Axonogenesis Axon Guidance Cell Population Proliferation Positive Regulation Of Gene Expression Olfactory Bulb Interneuron Differentiation Cell Differentiation Embryonic Limb Morphogenesis BMP Signaling Pathway Epithelial Cell Differentiation Inner Ear Morphogenesis Ear Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Embryonic Skeletal System Development Positive Regulation Of Epithelial Cell Proliferation Roof Of Mouth Development Olfactory Pit Development Head Development Face Morphogenesis Bone Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Interneuron Axon Guidance	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation In Utero Embryonic Development Neural Crest Cell Migration Morphogenesis Of An Epithelium Signal Transduction Spermatogenesis Peripheral Nervous System Development Male Gonad Development Positive Regulation Of Gene Expression Regulation Of Hormone Levels Positive Regulation Of Gliogenesis Neural Crest Cell Development Positive Regulation Of Osteoblast Proliferation Skeletal Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Photoreceptor Cell Differentiation Cell Maturation Enteric Nervous System Development Oligodendrocyte Differentiation Sertoli Cell Development Astrocyte Fate Commitment Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Adipose Tissue Development Morphogenesis Of A Branching Epithelium Renal Vesicle Induction Ureter Morphogenesis Metanephric Nephron Tubule Formation Positive Regulation Of Kidney Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Pathways		Regulation of RUNX2 expression and activity Specification of the neural plate border Developmental Lineage of Mammary Stem Cells
Drugs
Diseases
GWAS		Heel bone mineral density ( 28869591 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Morning vs. evening chronotype ( 26835600)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Logical memory (immediate recall) in normal cognition ( 29274321) Multiple sclerosis ( 21833088 31604244) Polycystic ovary syndrome ( 25574032)
Interacting Genes		9 interacting genes: DLX2 HOXC8 MAGED1 MSX1 MSX2 NCOA2 SOX10 SOX8 SPEN	18 interacting genes: CEBPA DLX5 EGR2 HHEX HOXC11 JAM2 JUN MMP1 NOD1 NR5A1 OLIG2 PAX3 PIDD1 POU3F3 POU5F1 SP1 TCF12 UTF1
Entrez ID		1749	30812
HPRD ID		02492	16175
Ensembl ID		ENSG00000105880	ENSG00000005513
Uniprot IDs		P56178 Q53Y73	P57073
PDB IDs		2DJN 4RDU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Developmental Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Mesenchymal Cell Apoptotic Process Morphogenesis Of A Branching Structure Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process Oligodendrocyte Differentiation Embryonic Nail Plate Morphogenesis Cell Surface Receptor Signaling Pathway Involved In Heart Development Positive Regulation Of Multicellular Organismal Process Activation Of Meiosis Animal Organ Morphogenesis Negative Regulation Of Photoreceptor Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Regulation Of Multicellular Organismal Process Transcription Cis-regulatory Region Binding Regionalization Regulation Of Gene Expression Regulation Of Animal Organ Morphogenesis Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Differentiation DNA Binding Regulation Of Primary Metabolic Process Mammary Gland Epithelium Development Odontogenesis Mesenchymal Cell Apoptotic Process Enteric Nervous System Development Regulation Of Gliogenesis Cartilage Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Glial Cell Differentiation Regulation Of Multicellular Organismal Development RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Stem Cell Differentiation Regulation Of Neurogenesis	Positive Regulation Of Transcription By RNA Polymerase II HMG Box Domain Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Positive Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Transcription Cis-regulatory Region Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Animal Organ Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulator Complex Response To Gonadotropin-releasing Hormone Positive Regulation Of Developmental Process Cellular Developmental Process Regulation Of Metabolic Process Developmental Process Regulation Of Multicellular Organismal Process Regulation Of Developmental Process System Development CAMP Response Element Binding Nucleus Transcription Regulator Complex Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Host-mediated Activation Of Viral Transcription Positive Regulation Of Canonical Wnt Signaling Pathway Nervous System Development Cell Differentiation Organ Induction Double-stranded DNA Binding
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