DIO3 and PRMT5

Number of citations of the paper that reports this interaction (PMID 17709427)
33

Data Source:
BioGRID (pull down)

		DIO3	PRMT5
Gene Name		deiodinase, iodothyronine, type III	protein arginine methyltransferase 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Endosome Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Methylosome
	Molecular Function	Thyroxine 5'-deiodinase Activity Thyroxine 5-deiodinase Activity	Core Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Histone-arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Ribonucleoprotein Complex Binding
	Biological Process	Thyroid Hormone Generation Biological_process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Multicellular Organism Growth Thyroid Hormone Catabolic Process Hormone Biosynthetic Process Small Molecule Metabolic Process Oxidation-reduction Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Spliceosomal SnRNP Assembly Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Mitotic Nuclear Division Cell Proliferation Gene Expression Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Circadian Regulation Of Gene Expression NcRNA Metabolic Process Peptidyl-arginine N-methylation Endothelial Cell Activation Histone H4-R3 Methylation
Pathways		Amine-derived hormones Regulation of thyroid hormone activity Thyroxine biosynthesis Metabolism of amino acids and derivatives	Chromatin modifying enzymes snRNP Assembly Chromatin organization Metabolism of non-coding RNA RMTs methylate histone arginines
Drugs
Diseases
GWAS		Type 1 diabetes ( 19966805)
Protein-Protein Interactions		3 interactors: APP PRMT5 PRMT7	67 interactors: ARGLU1 CALU CAPN1 CCAR2 CDYL2 CLK1 CLK3 CLNS1A COPRS CTDP1 DIO3 DNMT3A EZH2 FAM76B GRHL3 GTPBP2 H3F3C HIST1H3A HIST1H4A HIST2H2AC HOXC4 ING5 JAK1 JAK2 JAK3 LDHAL6B LENG8 LUC7L MAGEB2 MBP MCRS1 MEF2D MYOD1 MYOG NELFCD NUDCD2 OLA1 PHYHIP PRPF38A RBM23 RSRP1 SF3A3 SIN3A SLU7 SMARCA2 SMARCB1 SMARCC1 SMARCE1 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SSTR1 SUPT5H TRIB3 TYK2 WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZNF2 ZNF224 ZNF436 ZUFSP
Entrez ID		1735	10419
HPRD ID		11867	04955
Ensembl ID		ENSG00000197406	ENSG00000100462
Uniprot IDs		P55073 Q86TU3	O14744
PDB IDs			4GQB
Enriched GO Terms of Interacting Partners?		Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Histone H4-R3 Methylation Peptidyl-arginine N-methylation Histone Arginine Methylation Peptidyl-arginine Methylation MRNA Processing Spliceosomal SnRNP Assembly MRNA Metabolic Process RNA Processing Histone Methylation Regulation Of Protein Binding Protein Methylation Ribonucleoprotein Complex Assembly Synaptic Growth At Neuromuscular Junction MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Collateral Sprouting In Absence Of Injury Regulation Of Binding Cellular Component Assembly Ribonucleoprotein Complex Biogenesis Collateral Sprouting Axon Midline Choice Point Recognition RNA Splicing Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Histone Modification Axon Choice Point Recognition Methylation Regulation Of Mitotic Cell Cycle Neuron Remodeling Regulation Of Cell Cycle Process Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Endothelial Cell Activation Chromatin Modification Cellular Macromolecular Complex Assembly Cellular Copper Ion Homeostasis DNA Methylation Involved In Gamete Generation Cell Activation RNA Metabolic Process Cellular Protein Modification Process Chromatin Organization Copper Ion Homeostasis Suckling Behavior Regulation Of Gene Expression By Genetic Imprinting Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Gene Expression Sexual Reproduction Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Genetic Imprinting	Gene Expression RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Organization Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Chromatin Modification Regulation Of RNA Metabolic Process MRNA Processing Nitrogen Compound Metabolic Process Regulation Of Gene Expression Chromosome Organization Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated MRNA Metabolic Process RNA Splicing RNA Biosynthetic Process RNA Processing Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Regulation Of Transcription, DNA-templated MRNA Splicing, Via Spliceosome Regulation Of Nucleic Acid-templated Transcription RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Assembly Spliceosomal SnRNP Assembly Positive Regulation Of Gene Expression Cellular Macromolecular Complex Assembly Histone Modification Positive Regulation Of Macromolecule Biosynthetic Process Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Ribonucleoprotein Complex Biogenesis Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-tyrosine Autophosphorylation Peptidyl-amino Acid Modification Positive Regulation Of Transcription, DNA-templated DNA Methylation On Cytosine Chromatin Remodeling Regulation Of Metabolic Process Positive Regulation Of Viral Transcription Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Nucleosome Disassembly Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		capsule deleting distal dlk1 dysregulation e6 embryos encoded encodes engrafting gtl2 harbors hypertrophic maternally microarray mirnas ncrnas noncoding paternally reflects repression rnas scid suppressors teratoma teratomas tumorigenesis wildtype works	acquisition af9 arginine biomedical bypassing cooperates critically drive drivers forming inactivating inherent lymphomagenesis lymphomas mll modulator neoplastic notch1 oncogenic overt relevance renewal revealing selectively specimen supporting suppresses sustaining transferase
Tagcloud (Difference) ?		capsule deleting distal dlk1 dysregulation e6 embryos encoded encodes engrafting gtl2 harbors hypertrophic maternally microarray mirnas ncrnas noncoding paternally reflects repression rnas scid suppressors teratoma teratomas tumorigenesis wildtype works	acquisition af9 arginine biomedical bypassing cooperates critically drive drivers forming inactivating inherent lymphomagenesis lymphomas mll modulator neoplastic notch1 oncogenic overt relevance renewal revealing selectively specimen supporting suppresses sustaining transferase
Tagcloud (Intersection) ?