DIO3

Name	iodothyronine deiodinase 3
Structure	No pdb structure
Novel Interactors	2 novel interactors: C1QBP CKB
Interactors	3 interactors: APP PRMT5 PRMT7
GO Annotations	Cellular Component	Endosome Plasma Membrane Endosome Membrane Membrane
	Molecular Function	Thyroxine 5'-deiodinase Activity Oxidoreductase Activity Thyroxine 5-deiodinase Activity
	Biological Process	Response To Hypoxia Apoptotic Process Positive Regulation Of Multicellular Organism Growth Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process Retinal Cone Cell Development Brown Fat Cell Proliferation Retinal Cone Cell Apoptotic Process
Pathways	Regulation of thyroid hormone activity
Drugs	Iopodic acid
GWAS	Metabolite levels ( 23823483 ) Pulse pressure ( 30224653 ) Type 1 diabetes ( 19966805 )
Entrez ID	1735
HPRD ID	11867
Ensembl ID	ENSG00000197406
Uniprot IDs	P55073 Q86TU3
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Peptidyl-arginine Methylation Protein-arginine N-methyltransferase Activity Epigenetic Regulation Of Gene Expression Histone Methyltransferase Activity Protein Methylation Ribonucleoprotein Complex Binding Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Spliceosomal SnRNP Assembly Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Adrenergic Receptor Binding Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of G Protein-coupled Receptor Signaling Pathway Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Type II Interferon Production Positive Regulation Of Chemotaxis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Kininogen Binding Deoxyribonuclease Inhibitor Activity Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Futile Creatine Cycle Peptidyl-arginine N-methylation Histone Arginine N-methyltransferase Activity Macromolecule Methylation Methyltransferase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Chromatin Organization Cellular Response To Norepinephrine Stimulus