DDX42 and PRPF19

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid, two hybrid)

		DDX42	PRPF19
Description		DEAD-box helicase 42	pre-mRNA processing factor 19
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Membrane Nuclear Speck U2-type Prespliceosome	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Spliceosomal Complex Cytoplasm Lipid Droplet Spindle Cytoskeleton Membrane Nuclear Speck Site Of Double-strand Break U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Intracellular Protein Localization Regulation Of Apoptotic Process U2-type Prespliceosome Assembly	DNA Damage Checkpoint Signaling Protein Polyubiquitination Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome Inner Cell Mass Cell Proliferation DNA Repair Double-strand Break Repair Via Nonhomologous End Joining MRNA Processing DNA Damage Response Intracellular Protein Localization RNA Splicing Lipid Biosynthetic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Positive Regulation Of MRNA Splicing, Via Spliceosome Protein K63-linked Ubiquitination
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Body mass index ( 25673413) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		13 interacting genes: APP DHX15 FBXO25 LINC00624 MAILR MDM2 PRPF19 RECQL5 RNF10 SF3A1 SF3B4 SNRPC U2SURP	24 interacting genes: CEBPA CTBP1 DDX42 DNTT EGLN3 ESR1 EXOC7 GATA4 GSTK1 HSPB1 MYL9 OGT POLR2A PSMB4 PTEN RBFOX2 RPA1 RPA3 SETMAR SMNDC1 U2AF1 UBE2D3 USP7 VPS35
Entrez ID		11325	27339
HPRD ID		09909	12214
Ensembl ID		ENSG00000198231	ENSG00000110107
Uniprot IDs		Q86XP3	Q9UMS4
PDB IDs		7EVN 8DPE 8HK1	4LG8 5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P 7W59 7W5A 7W5B 8C6J 8CH6 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Splicing, Via Transesterification Reactions U2 SnRNP RNA Splicing Spliceosomal Complex Assembly MRNA Processing Protein-RNA Complex Assembly RNA Processing Response To Alkaloid Nucleic Acid Binding MRNA Metabolic Process U2-type Prespliceosome Protein-containing Complex Assembly U12-type Spliceosomal Complex U2-type Prespliceosome Assembly Amyloid Fibril Formation U2-type Spliceosomal Complex MRNA Splice Site Recognition Protein-containing Complex Organization Cellular Response To Alkaloid Macromolecule Metabolic Process Spliceosomal SnRNP Assembly Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Nucleus Response To Formaldehyde Cellular Response To Vitamin B1 U2-type Precatalytic Spliceosome Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Autoubiquitination Acetylcholine Receptor Activator Activity Lipoprotein Particle Regulation Of Receptor Internalization Positive Regulation Of Protein Import Protein Modification By Small Protein Conjugation Mitotic DNA-templated DNA Replication PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization	Nucleoplasm Nucleus Nucleic Acid Metabolic Process Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Repair Nucleotide-excision Repair DNA Damage Response Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA-binding Transcription Factor Binding Nucleic Acid Binding Cajal Body RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Autophagy DNA Replication Factor A Complex White Fat Cell Differentiation Double-strand Break Repair Site Of Double-strand Break Response To Stress DNA Metabolic Process Rhythmic Process Estrogen Receptor Signaling Pathway PML Body Single-stranded DNA Binding Negative Regulation Of Protein Catabolic Process Mismatch Repair Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Nutrient Condensed Chromosome Base-excision Repair RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA Nucleotidylexotransferase Activity Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Synaptic Vesicle Clustering Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Terminal Button Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Regulation Of Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Proteolysis Negative Regulation Of Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Carbohydrate Homeostasis
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