DDX42 and U2SURP

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid, two hybrid)

		DDX42	U2SURP
Description		DEAD-box helicase 42	U2 snRNP associated SURP domain containing
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Membrane Nuclear Speck U2-type Prespliceosome	Nucleus Nucleoplasm U2 SnRNP
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity	Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	Intracellular Protein Localization Regulation Of Apoptotic Process U2-type Prespliceosome Assembly	RNA Processing
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Body mass index ( 25673413) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 25673412)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean platelet volume ( 32888494) Urate levels ( 31578528)
Interacting Genes		13 interacting genes: APP DHX15 FBXO25 LINC00624 MAILR MDM2 PRPF19 RECQL5 RNF10 SF3A1 SF3B4 SNRPC U2SURP	63 interacting genes: CEBPA CTNNBL1 DDX42 H19 MIR1-1 MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR143 MIR145 MIR155 MIR15B MIR18A MIR18B MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR92A1 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PRPF40A RNF10 TBC1D4 TERT TRA2A
Entrez ID		11325	23350
HPRD ID		09909	19056
Ensembl ID		ENSG00000198231	ENSG00000163714
Uniprot IDs		Q86XP3	O15042
PDB IDs		7EVN 8DPE 8HK1
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Splicing, Via Transesterification Reactions U2 SnRNP RNA Splicing Spliceosomal Complex Assembly MRNA Processing Protein-RNA Complex Assembly RNA Processing Response To Alkaloid Nucleic Acid Binding MRNA Metabolic Process U2-type Prespliceosome Protein-containing Complex Assembly U12-type Spliceosomal Complex U2-type Prespliceosome Assembly Amyloid Fibril Formation U2-type Spliceosomal Complex MRNA Splice Site Recognition Protein-containing Complex Organization Cellular Response To Alkaloid Macromolecule Metabolic Process Spliceosomal SnRNP Assembly Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Nucleus Response To Formaldehyde Cellular Response To Vitamin B1 U2-type Precatalytic Spliceosome Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Autoubiquitination Acetylcholine Receptor Activator Activity Lipoprotein Particle Regulation Of Receptor Internalization Positive Regulation Of Protein Import Protein Modification By Small Protein Conjugation Mitotic DNA-templated DNA Replication PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Extracellular Vesicle Positive Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of MRNA Stability Negative Regulation Of Angiogenesis Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Macromolecule Biosynthetic Process Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of RNA Stability Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Developmental Process Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Translation Regulation Of Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Migration Negative Regulation Of Signal Transduction Regulation Of Cell Motility Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Anatomical Structure Morphogenesis Regulation Of Locomotion Regulation Of Endothelial Cell Migration Positive Regulation Of Catabolic Process
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