CNKSR3 and DLL1

Number of citations of the paper that reports this interaction (PMID 15509766)
19

Data Source:
HPRD (in vitro)

		CNKSR3	DLL1
Gene Name		CNKSR family member 3	delta-like 1 (Drosophila)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle
	Molecular Function		Notch Binding Calcium Ion Binding Protein Binding
	Biological Process	Positive Regulation Of Sodium Ion Transport Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade	Cell Fate Determination Somite Specification Heart Looping Notch Signaling Pathway Notch Receptor Processing Cell-cell Signaling Determination Of Left/right Symmetry Compartment Pattern Specification Hemopoiesis Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Interleukin-10 Production Negative Regulation Of Auditory Receptor Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Inner Ear Development Left/right Axis Specification Proximal Tubule Development Loop Of Henle Development Neuronal Stem Cell Maintenance
Pathways			Signaling by NOTCH4 Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Parkinson's disease ( 22451204) Renal function-related traits (eGRFcrea) ( 22797727)	Type 1 diabetes ( 21980299)
Protein-Protein Interactions		2 interactors: DLL1 NMI	10 interactors: ADAM10 CNKSR3 MAGI2 MFNG NOTCH1 NOTCH2 NOTCH3 NOV POFUT1 PSEN1
Entrez ID		154043	28514
HPRD ID		14349	05957
Ensembl ID			ENSG00000198719
Uniprot IDs		Q6P9H4	O00548
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Auditory Receptor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Regulation Of Auditory Receptor Cell Differentiation Compartment Pattern Specification Somite Specification Proximal Tubule Development Negative Regulation Of Epidermal Cell Differentiation Loop Of Henle Development Left/right Axis Specification Negative Regulation Of Interleukin-10 Production Segment Specification Left/right Pattern Formation Notch Receptor Processing Neuronal Stem Cell Maintenance Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Regulation Of Epidermal Cell Differentiation Cell Fate Determination JAK-STAT Cascade Heart Looping Regulation Of Notch Signaling Pathway Determination Of Heart Left/right Asymmetry Regulation Of Epidermis Development Embryonic Heart Tube Morphogenesis Somitogenesis Negative Regulation Of Myeloid Cell Differentiation Embryonic Heart Tube Development Embryonic Pattern Specification Somite Development Renal Tubule Development Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Axis Specification Segmentation Notch Signaling Pathway Regulation Of Epithelial Cell Differentiation Nephron Development Stem Cell Maintenance Kidney Epithelium Development	Notch Receptor Processing Notch Signaling Pathway Nervous System Development Anatomical Structure Morphogenesis Pattern Specification Process Blood Vessel Development Vasculature Development Epithelium Development Glomerulus Development Cell Surface Receptor Signaling Pathway Cell Fate Commitment Multicellular Organismal Development Interleukin-4 Secretion Notch Signaling Involved In Heart Development Pulmonary Valve Morphogenesis Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Interleukin-4 Production Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Generation Of Neurons Cardiovascular System Development Developmental Process Neurogenesis Membrane Protein Ectodomain Proteolysis Tissue Development Nephron Development System Development Cell Development Embryonic Limb Morphogenesis Myeloid Dendritic Cell Differentiation Glomerulus Vasculature Development Morphogenesis Of An Epithelium Heart Development Transcription Initiation From RNA Polymerase II Promoter Organ Development Myeloid Dendritic Cell Activation Neuron Differentiation Limb Morphogenesis Regulation Of Neuron Differentiation Embryo Development Negative Regulation Of Neuron Differentiation Limb Development Regulation Of Cell Migration Membrane Protein Proteolysis Cardiac Atrium Morphogenesis Inflammatory Response To Antigenic Stimulus Cytokine Secretion Heart Morphogenesis Regulation Of Cell Motility
Tagcloud ?			ameliorates asked commitment conditional corroborate duchenne dystrophic dystrophies efficaciousness engraftment eudract hold impairs interplay mab mabs mef2c mesoangioblasts muscular myogenic notch notch1 pericytes played potentiate regenerate regenerative satellite tuning
Tagcloud (Difference) ?			ameliorates asked commitment conditional corroborate duchenne dystrophic dystrophies efficaciousness engraftment eudract hold impairs interplay mab mabs mef2c mesoangioblasts muscular myogenic notch notch1 pericytes played potentiate regenerate regenerative satellite tuning
Tagcloud (Intersection) ?