CNKSR3 and DLL1

Number of citations of the paper that reports this interaction (PubMedID 15509766)
0

Data Source:
HPRD (in vitro)

		CNKSR3	DLL1
Description		CNKSR family member 3	delta like canonical Notch ligand 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Apical Plasma Membrane	Extracellular Region Plasma Membrane Adherens Junction Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Raft Anchoring Junction
	Molecular Function	Protein Binding	Notch Binding Calcium Ion Binding Protein Binding Tat Protein Binding Receptor Ligand Activity Scaffold Protein Binding
	Biological Process	Regulation Of Signal Transduction Positive Regulation Of Sodium Ion Transport Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade	Cell Fate Determination Somitogenesis Somite Specification Heart Looping Inhibition Of Neuroepithelial Cell Differentiation Marginal Zone B Cell Differentiation Type B Pancreatic Cell Development Cell Communication Notch Signaling Pathway Cell-cell Signaling Determination Of Left/right Symmetry Compartment Pattern Specification Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Proximal/distal Pattern Formation Positive Regulation Of Gene Expression Astrocyte Development Regulation Of Somitogenesis Spinal Cord Development Cerebellar Molecular Layer Formation Cerebellar Purkinje Cell Layer Structural Organization Hemopoiesis Myeloid Cell Differentiation Cell Differentiation Regulation Of Cell Adhesion Neuron Differentiation Negative Regulation Of Epithelial Cell Differentiation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Interleukin-10 Production Negative Regulation Of Glial Cell Apoptotic Process Organ Growth Regulation Of Growth Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Lateral Inhibition Skeletal Muscle Tissue Growth Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Tissue Growth Neuron Fate Specification Inner Ear Development Regulation Of Neurogenesis Regulation Of Cell Division Retina Development In Camera-type Eye Retina Morphogenesis In Camera-type Eye Neuroepithelial Cell Differentiation Notch Signaling Pathway Involved In Arterial Endothelial Cell Fate Commitment Left/right Axis Specification Nephron Development Proximal Tubule Development Loop Of Henle Development Clathrin-dependent Endocytosis Energy Homeostasis Endothelial Tip Cell Fate Specification Neuronal Stem Cell Population Maintenance Skin Epidermis Development Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways			Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus MECP2 regulates transcription of neuronal ligands Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Formation of paraxial mesoderm Somitogenesis Nephron development
Drugs
Diseases
GWAS		Diabetic kidney disease ( 26305897) Estimated glomerular filtration rate ( 31152163) Lipoprotein (a) levels ( 26377243) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Nontraumatic osteonecrosis of the femoral head ( 32701715) Parkinson's disease ( 22451204) Renal function-related traits (eGRFcrea) ( 22797727) Type 2 diabetes (age of onset) ( 28060188)	Interferon alpha levels in systemic lupus erythematosus ( 25338677) Intraocular pressure ( 29785010) Plasma anti-thyroglobulin levels ( 29678681) Type 1 diabetes ( 21980299)
Interacting Genes		10 interacting genes: AKT1 CDKN2B DDX6 DLL1 EIF4A3 FAM76B GPKOW JRK N4BP3 NMI	10 interacting genes: ADAM10 CCN3 CNKSR3 MAGI2 MFNG NOTCH1 NOTCH2 NOTCH3 POFUT1 PSEN1
Entrez ID		154043	28514
HPRD ID		14349	05957
Ensembl ID		ENSG00000153721	ENSG00000198719
Uniprot IDs		A0A5H1ZRR2 Q6P9H4	A0A384P5C6 O00548
PDB IDs			4XBM
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Gene Expression Response To Nerve Growth Factor Negative Regulation Of Notch Signaling Pathway Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation Maintenance Of Protein Location Cell Surface Pattern Recognition Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Regulation Of TRNA Methylation Maintenance Of Protein Localization In Organelle Maintenance Of Protein Location In Cell Cellular Response To Nerve Growth Factor Stimulus Concave Side Of Sperm Head Nucleic Acid Binding MRNA Binding Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion Notch Signaling Pathway Involved In Arterial Endothelial Cell Fate Commitment Cerebellar Molecular Layer Formation Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Maintenance Of Location In Cell Regulation Of MRNA Metabolic Process RNA Helicase Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Notch Signaling Pathway Negative Regulation Of RNA Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Translation Response To Insulin-like Growth Factor Stimulus Maintenance Of Location Positive Regulation Of Cell Communication Mammalian Oogenesis Stage Positive Regulation Of Signaling Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane TRNA (guanine-N7)-methylation Negative Regulation Of Macromolecule Metabolic Process TORC2 Complex Binding Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Signal Transduction RNA Stabilization Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity SREBP-SCAP Complex Retention In Endoplasmic Reticulum Cellular Response To Cell-matrix Adhesion Stem Cell Population Maintenance	Notch Signaling Pathway Regulation Of Notch Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Golgi Membrane Angiogenesis Protein Catabolic Process At Postsynapse Cellular Response To Tumor Cell Regulation Of Signal Transduction Pattern Specification Process Positive Regulation Of Notch Signaling Pathway Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Atrioventricular Node Development Glomerular Capillary Formation Heart Looping Embryonic Heart Tube Morphogenesis Forebrain Development Marginal Zone B Cell Differentiation Cell Surface Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryonic Limb Morphogenesis Podocyte Development Tube Morphogenesis Cell Surface Receptor Signaling Pathway Limb Morphogenesis Left/right Axis Specification Epithelial Tube Morphogenesis Amyloid Precursor Protein Catabolic Process Lymphocyte Activation Involved In Immune Response Pulmonary Valve Morphogenesis Positive Regulation Of Ras Protein Signal Transduction Negative Regulation Of Myotube Differentiation Myeloid Leukocyte Activation Epithelial Cell Development Morphogenesis Of An Epithelial Sheet Myeloid Dendritic Cell Differentiation Nephron Tubule Development Positive Regulation Of Smooth Muscle Cell Differentiation Membrane Protein Ectodomain Proteolysis Notch Binding Amyloid Precursor Protein Metabolic Process Leukocyte Activation Involved In Immune Response Regulation Of Muscle Cell Differentiation Cell Activation Involved In Immune Response Renal Tubule Development Anterior/posterior Pattern Specification Myeloid Dendritic Cell Activation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mature B Cell Differentiation Involved In Immune Response
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