CNKSR3 and GPKOW

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CNKSR3	GPKOW
Description		CNKSR family member 3	G-patch domain and KOW motifs
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Apical Plasma Membrane	Nucleus Nucleoplasm Spliceosomal Complex
	Molecular Function	Protein Binding	Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	Regulation Of Signal Transduction Positive Regulation Of Sodium Ion Transport Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Diabetic kidney disease ( 26305897) Estimated glomerular filtration rate ( 31152163) Lipoprotein (a) levels ( 26377243) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Nontraumatic osteonecrosis of the femoral head ( 32701715) Parkinson's disease ( 22451204) Renal function-related traits (eGRFcrea) ( 22797727) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		10 interacting genes: AKT1 CDKN2B DDX6 DLL1 EIF4A3 FAM76B GPKOW JRK N4BP3 NMI	47 interacting genes: APP ARMCX1 BUD13 CCDC57 CNKSR3 DDIT4L EFHC2 FBXO7 GMPPA GOLGA2 GSTM5 HOOK2 HSF2BP IKBKG KANK2 LNX1 LRP2BP LZTS1 MAD1L1 MEOX2 MESD MID2 MTUS2 NINL OGT PHF1 PIBF1 PICK1 POLR2G PPP1CA PRKAR1B PRPF4 PRPF8 REL ROPN1 SH3GL1 SORBS3 SPDYE4 TCEA1 TCEA2 TRAF2 TRIM23 TRIM27 VPS52 WDR77 WDR83 ZMYND12
Entrez ID		154043	27238
HPRD ID		14349	06737
Ensembl ID		ENSG00000153721	ENSG00000068394
Uniprot IDs		A0A5H1ZRR2 Q6P9H4	Q92917
PDB IDs			7DVQ 7QTT 8CH6
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Gene Expression Response To Nerve Growth Factor Negative Regulation Of Notch Signaling Pathway Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation Maintenance Of Protein Location Cell Surface Pattern Recognition Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Regulation Of TRNA Methylation Maintenance Of Protein Localization In Organelle Maintenance Of Protein Location In Cell Cellular Response To Nerve Growth Factor Stimulus Concave Side Of Sperm Head Nucleic Acid Binding MRNA Binding Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion Notch Signaling Pathway Involved In Arterial Endothelial Cell Fate Commitment Cerebellar Molecular Layer Formation Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Maintenance Of Location In Cell Regulation Of MRNA Metabolic Process RNA Helicase Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Notch Signaling Pathway Negative Regulation Of RNA Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Translation Response To Insulin-like Growth Factor Stimulus Maintenance Of Location Positive Regulation Of Cell Communication Mammalian Oogenesis Stage Positive Regulation Of Signaling Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane TRNA (guanine-N7)-methylation Negative Regulation Of Macromolecule Metabolic Process TORC2 Complex Binding Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Signal Transduction RNA Stabilization Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity SREBP-SCAP Complex Retention In Endoplasmic Reticulum Cellular Response To Cell-matrix Adhesion Stem Cell Population Maintenance	Cytoplasm Protein Binding Identical Protein Binding Regulation Of Autophagy Positive Regulation Of Autophagy
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