CNKSR3 and FAM76B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CNKSR3	FAM76B
Description		CNKSR family member 3	family with sequence similarity 76 member B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Apical Plasma Membrane	Nucleus Nuclear Speck
	Molecular Function	Protein Binding	RNA Binding Protein Binding
	Biological Process	Regulation Of Signal Transduction Positive Regulation Of Sodium Ion Transport Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade	Negative Regulation Of Macrophage Activation Negative Regulation Of Protein Export From Nucleus MRNA Stabilization Negative Regulation Of Inflammatory Response
Pathways
Drugs
Diseases
GWAS		Diabetic kidney disease ( 26305897) Estimated glomerular filtration rate ( 31152163) Lipoprotein (a) levels ( 26377243) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Nontraumatic osteonecrosis of the femoral head ( 32701715) Parkinson's disease ( 22451204) Renal function-related traits (eGRFcrea) ( 22797727) Type 2 diabetes (age of onset) ( 28060188)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Chronotype ( 30696823) Diastolic blood pressure ( 27841878) Feeling worry ( 29500382) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Keratoconus ( 33649486) Macular thickness ( 30535121) Monocyte count ( 29403010) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Refractive error ( 32231278) Sun-seeking behavior ( 32920024) Triglyceride levels x loop diuretics use interaction ( 31806883) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White blood cell count ( 29403010)
Interacting Genes		10 interacting genes: AKT1 CDKN2B DDX6 DLL1 EIF4A3 FAM76B GPKOW JRK N4BP3 NMI	22 interacting genes: CEBPA CNKSR3 GRN KRTAP1-1 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-2 KRTAP5-9 KRTAP9-2 PRMT5 SRPK1 SRPK2
Entrez ID		154043	143684
HPRD ID		14349	11333
Ensembl ID		ENSG00000153721	ENSG00000077458
Uniprot IDs		A0A5H1ZRR2 Q6P9H4	F5GX09 Q5HYJ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Gene Expression Response To Nerve Growth Factor Negative Regulation Of Notch Signaling Pathway Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation Maintenance Of Protein Location Cell Surface Pattern Recognition Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Regulation Of TRNA Methylation Maintenance Of Protein Localization In Organelle Maintenance Of Protein Location In Cell Cellular Response To Nerve Growth Factor Stimulus Concave Side Of Sperm Head Nucleic Acid Binding MRNA Binding Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion Notch Signaling Pathway Involved In Arterial Endothelial Cell Fate Commitment Cerebellar Molecular Layer Formation Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Maintenance Of Location In Cell Regulation Of MRNA Metabolic Process RNA Helicase Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Notch Signaling Pathway Negative Regulation Of RNA Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Translation Response To Insulin-like Growth Factor Stimulus Maintenance Of Location Positive Regulation Of Cell Communication Mammalian Oogenesis Stage Positive Regulation Of Signaling Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane TRNA (guanine-N7)-methylation Negative Regulation Of Macromolecule Metabolic Process TORC2 Complex Binding Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Signal Transduction RNA Stabilization Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity SREBP-SCAP Complex Retention In Endoplasmic Reticulum Cellular Response To Cell-matrix Adhesion Stem Cell Population Maintenance	Intermediate Filament Keratin Filament Hair Cycle Cytosol Regulation Of MRNA Splicing, Via Spliceosome
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