CNOT2 and TBX2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CNOT2	TBX2
Name		CCR4-NOT transcription complex subunit 2	T-box transcription factor 2
Structure			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane CCR4-NOT Complex CCR4-NOT Core Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm
	Molecular Function	Transcription Corepressor Binding Transcription Coregulator Activity Poly(A)-specific Ribonuclease Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Translation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Stem Cell Population Maintenance	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Endocardial Cushion Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Notch Signaling Pathway Muscle Cell Fate Determination Regulation Of Heart Contraction Fibroblast Growth Factor Receptor Signaling Pathway Neurogenesis Response To Retinoic Acid Embryonic Heart Tube Development Aorta Morphogenesis Atrioventricular Canal Development Embryonic Digit Morphogenesis Pigment Metabolic Process Involved In Pigmentation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis Cardiac Muscle Tissue Development Smooth Muscle Cell Differentiation Roof Of Mouth Development Pharyngeal System Development Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Cell Myoblast Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis Developmental Growth Involved In Morphogenesis Mammary Placode Formation Mesenchymal Cell Proliferation Involved In Lung Development Cellular Response To Dexamethasone Stimulus Ureteric Peristalsis Cochlea Morphogenesis Cellular Senescence Melanocyte Proliferation Negative Regulation Of Heart Looping Negative Regulation Of Cardiac Chamber Formation Positive Regulation Of Cell Cycle G1/S Phase Transition Cardiac Jelly Development Atrioventricular Canal Morphogenesis Negative Regulation Of Cellular Senescence
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors	Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728 ) Diastolic blood pressure ( 27841878 ) Ovarian cancer ( 30557369 ) Triglyceride levels ( 32154731 )	Age-related hearing impairment ( 34108613 ) Anthropometric traits ( 30166351 ) Anthropometric traits (multi-trait analysis) ( 30166351 ) Chloride levels ( 29403010 ) Chronic kidney disease ( 20383146 ) Circulating fibroblast growth factor 23 levels ( 30217807 ) Corneal hysteresis ( 32716492 ) Corneal resistance factor ( 32716492 ) Coronary artery disease ( 29212778 ) Creatinine levels ( 31015462 20383145 ) Diastolic blood pressure ( 30487518 27618448 27618447 27841878 ) Estimated glomerular filtration rate ( 31015462 ) Height ( 19893584 18391951 20881960 ) Hypertension ( 30487518 27618447 ) Kidney volume ( 34128465 ) Mean arterial pressure ( 27618448 30487518 26390057 ) Potassium levels ( 29403010 ) Pulse pressure ( 27841878 27618447 ) Refractive error ( 32231278 ) Sitting height ratio ( 25865494 ) Spontaneous preterm birth without premature rupture of membranes ( 31194736 ) Systolic blood pressure ( 30487518 28739976 27618447 27618448 27841878 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		27 interacting genes: ARMC5 BCL6 BEX1 CCHCR1 CFAP68 CIMIP1 CNOT1 CNOT3 CNOT8 CSTF2 DDB1 DSCR9 GALNT10 GCSAM GPS1 GPS2 HSF2BP MTFR1L NCOR1 NCOR2 OBI1 PRR35 PSMB4 RACK1 TBX2 TEKT3 ZFHX3	12 interacting genes: ATXN1L CEBPE CIDEB CNOT2 CYSRT1 KRTAP6-3 LMO2 LZTR1 MEIS2 NKX2-5 TNPO2 TTC19
Entrez ID		4848	6909
HPRD ID		05367	02850
Ensembl ID		ENSG00000111596	ENSG00000121068
Uniprot IDs		B2RDX7 B3KTL6 F8VUB4 F8VV52 Q9NZN8	Q13207
PDB IDs		4C0D 4C0F 5FU6 5FU7	Not available
GO Terms Enriched among Interactors		CCR4-NOT Core Complex CCR4-NOT Complex Nuclear-transcribed MRNA Poly(A) Tail Shortening Rhythmic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction GTPase Inhibitor Activity Transcription Repressor Complex Poly(A)-specific Ribonuclease Activity RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nuclear Retinoic Acid Receptor Binding Trophectodermal Cell Differentiation Negative Regulation Of Androgen Receptor Signaling Pathway Nucleus P-body Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cellular Senescence Regulation Of B Cell Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process Axonemal A Tubule Inner Sheath Negative Regulation Of MiRNA Transcription Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process MRNA Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of JNK Cascade Cyclin Binding Negative Regulation Of Cardiac Chamber Formation Histone Deacetylase Binding Negative Regulation Of Heart Looping Regulation Of Androgen Receptor Signaling Pathway Regulation Of Brood Size Outer Acrosomal Membrane Adrenal Cortex Development Negative Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process	None