CNOT2 and CNOT1

Number of citations of the paper that reports this interaction (PubMedID 16778766)
44

Data Source:
HPRD (two hybrid, in vivo)

		CNOT2	CNOT1
Description		CCR4-NOT transcription complex subunit 2	CCR4-NOT transcription complex subunit 1
Image
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane CCR4-NOT Complex CCR4-NOT Core Complex	P-body Extracellular Space Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	Transcription Corepressor Binding Transcription Coregulator Activity Poly(A)-specific Ribonuclease Activity Protein Binding	RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Protein Domain Specific Binding Nuclear Estrogen Receptor Binding Nuclear Retinoic Acid Receptor Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Translation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Stem Cell Population Maintenance	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Translation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Stem Cell Population Maintenance
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Diastolic blood pressure ( 27841878) Ovarian cancer ( 30557369) Triglyceride levels ( 32154731)	Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) HDL cholesterol levels ( 32203549) HDL cholesterol levels in HIV infection ( 33109212) Liver enzyme levels (alanine transaminase) ( 33972514) Oily fish consumption ( 32066663) Platelet count ( 32888494) Pork consumption ( 32066663) PR interval ( 32439900) Pulse pressure ( 30224653) QT interval ( 30679814 19305408 29874175 24952745 22726844) Schizophrenia ( 30285260 29483656 25056061) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		27 interacting genes: ARMC5 BCL6 BEX1 CCHCR1 CFAP68 CIMIP1 CNOT1 CNOT3 CNOT8 CSTF2 DDB1 DSCR9 GALNT10 GCSAM GPS1 GPS2 HSF2BP MTFR1L NCOR1 NCOR2 OBI1 PRR35 PSMB4 RACK1 TBX2 TEKT3 ZFHX3	13 interacting genes: CDC42 CEBPA CNOT2 CNOT3 CNOT4 CNOT8 DDX6 NANOS3 OBI1 PPARG RARA RXRA THRB
Entrez ID		4848	23019
HPRD ID		05367	11999
Ensembl ID		ENSG00000111596	ENSG00000125107
Uniprot IDs		B2RDX7 B3KTL6 F8VUB4 F8VV52 Q9NZN8	A5YKK6
PDB IDs		4C0D 4C0F 5FU6 5FU7	4C0D 4CQO 4CRU 4CRV 4CRW 4CT4 4CT6 4CT7 4GMJ 4GML 4J8S 5ANR 5FU6 5FU7 5ONA 7VOI 8BFI 8FY3 9FL8
Enriched GO Terms of Interacting Partners?		CCR4-NOT Core Complex CCR4-NOT Complex Nuclear-transcribed MRNA Poly(A) Tail Shortening Rhythmic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction GTPase Inhibitor Activity Transcription Repressor Complex Poly(A)-specific Ribonuclease Activity RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nuclear Retinoic Acid Receptor Binding Trophectodermal Cell Differentiation Negative Regulation Of Androgen Receptor Signaling Pathway Nucleus P-body Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cellular Senescence Regulation Of B Cell Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process Axonemal A Tubule Inner Sheath Negative Regulation Of MiRNA Transcription Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process MRNA Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of JNK Cascade Cyclin Binding Negative Regulation Of Cardiac Chamber Formation Histone Deacetylase Binding Negative Regulation Of Heart Looping Regulation Of Androgen Receptor Signaling Pathway Regulation Of Brood Size Outer Acrosomal Membrane Adrenal Cortex Development Negative Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process	CCR4-NOT Complex Negative Regulation Of Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Biosynthetic Process Retinoic Acid Receptor Signaling Pathway CCR4-NOT Core Complex Negative Regulation Of Macromolecule Metabolic Process P-body MRNA Metabolic Process Negative Regulation Of Metabolic Process MRNA Transcription By RNA Polymerase II Cell Differentiation RNA Polymerase II Transcription Regulator Complex Nuclear Receptor Activity MRNA Transcription Negative Regulation Of Gene Expression Cellular Developmental Process RNA Metabolic Process Regulation Of Translation Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process Regulation Of Gene Expression Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process DNA Binding Domain Binding MRNA Catabolic Process Regulation Of Metabolic Process Positive Regulation Of Lipoprotein Transport Myeloid Leukocyte Differentiation Response To Nutrient Hormone-mediated Signaling Pathway Regulation Of Thyroid Hormone Receptor Signaling Pathway Post-transcriptional Regulation Of Gene Expression LBD Domain Binding Retinoic Acid-responsive Element Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System Negative Regulation Of Transcription By RNA Polymerase II Regulatory NcRNA-mediated Gene Silencing Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Macromolecule Catabolic Process Enzyme Binding RNA Catabolic Process Chromatin Nucleic Acid Metabolic Process Protein Autoubiquitination Regulation Of Protein Metabolic Process
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