CNOT2 and GPS2

Number of citations of the paper that reports this interaction (PMID 16712523)
7

Data Source:
BioGRID (two hybrid)

		CNOT2	GPS2
Gene Name		CCR4-NOT transcription complex, subunit 2	G protein pathway suppressor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane CCR4-NOT Complex	Nucleoplasm Transcriptional Repressor Complex
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity RNA Polymerase II Transcription Corepressor Binding Poly(A)-specific Ribonuclease Activity Protein Binding	Transcription Corepressor Activity GTPase Inhibitor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Translation Gene Expression Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing By RNA Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Stem Cell Maintenance	Negative Regulation Of Transcription From RNA Polymerase II Promoter Inactivation Of MAPK Activity Chromatin Organization Cell Cycle JNK Cascade Negative Regulation Of JNK Cascade
Pathways		Deadenylation of mRNA Deadenylation-dependent mRNA decay	Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728)
Protein-Protein Interactions		7 interactors: CNOT1 CNOT3 CNOT8 DDB1 GPS2 NCOR1 NCOR2	23 interactors: ATF4 C19orf57 CCNA1 CHD3 CNOT2 EP300 GOLGA2 HDAC1 HDAC3 KRT31 MAP3K7CL NCOR1 NR0B2 PBK RALBP1 RBPMS SESTD1 SETDB1 SPDL1 TBL1X TBL1XR1 TFIP11 TP53
Entrez ID		4848	2874
HPRD ID		05367	11878
Ensembl ID		ENSG00000111596	ENSG00000132522
Uniprot IDs		B2RDX7 B3KTL6 Q9NZN8	Q13227
PDB IDs			2L5G
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Gene Expression Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Silencing By RNA MRNA 3'-end Processing Gene Silencing RNA 3'-end Processing Aromatic Compound Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Positive Regulation Of MRNA Catabolic Process RNA Catabolic Process Regulation Of Stem Cell Maintenance Chromatin Organization RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Negative Regulation Of JNK Cascade Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Silencing By MiRNA Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Translation Cellular Macromolecule Catabolic Process Posttranscriptional Gene Silencing Regulation Of Cellular Protein Metabolic Process Chromosome Organization Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process MRNA Processing Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Posttranscriptional Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process MRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Phosphodiester Bond Hydrolysis Regulation Of Gene Expression RNA Processing Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway	Notch Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Chromosome Organization Transcription, DNA-templated Circadian Rhythm Negative Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification RNA Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Rhythmic Process Histone Deacetylation Protein Deacetylation Negative Regulation Of Cellular Metabolic Process Circadian Regulation Of Gene Expression Regulation Of Gene Expression Histone Modification Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cell Cycle Process Macromolecule Biosynthetic Process Mitotic Cell Cycle Organelle Organization Nucleobase-containing Compound Metabolic Process Histone H3-K9 Modification Regulation Of Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Protein Deacetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process
Tagcloud ?		11q23 12q11 12q14 12q15 12q21 17q11 17q12 3p12 6p21 6q21 6q23 9p13 9p21 acc accs adenoid amplicons ccnd3 cnas glipr1l1 mec mecs mucoepidermoid numa1 pax5 pvrl1 rab3ip sdc statuses	abnormal assigned calculated cop count css escc esophageal esophagectomy follows glasgow gps0 gps1 hypoalbuminemia indexes kaplan log lymphocyte meier neutrophil nlr nlr0 nlr1 nlr2 platelet predicts prognostic rank
Tagcloud (Difference) ?		11q23 12q11 12q14 12q15 12q21 17q11 17q12 3p12 6p21 6q21 6q23 9p13 9p21 acc accs adenoid amplicons ccnd3 cnas glipr1l1 mec mecs mucoepidermoid numa1 pax5 pvrl1 rab3ip sdc statuses	abnormal assigned calculated cop count css escc esophageal esophagectomy follows glasgow gps0 gps1 hypoalbuminemia indexes kaplan log lymphocyte meier neutrophil nlr nlr0 nlr1 nlr2 platelet predicts prognostic rank
Tagcloud (Intersection) ?