CNOT2 and CNOT8

Number of citations of the paper that reports this interaction (PMID 16778766)
20

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CNOT2	CNOT8
Gene Name		CCR4-NOT transcription complex, subunit 2	CCR4-NOT transcription complex, subunit 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane CCR4-NOT Complex	Intracellular Nucleus Cytosol CCR4-NOT Complex
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity RNA Polymerase II Transcription Corepressor Binding Poly(A)-specific Ribonuclease Activity Protein Binding	3'-5'-exoribonuclease Activity Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Translation Gene Expression Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing By RNA Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Stem Cell Maintenance	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Translation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Gene Expression Gene Silencing By MiRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Deadenylation of mRNA Deadenylation-dependent mRNA decay	Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728)
Protein-Protein Interactions		7 interactors: CNOT1 CNOT3 CNOT8 DDB1 GPS2 NCOR1 NCOR2	9 interactors: BTG1 BTG2 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 PRMT1 TOB2
Entrez ID		4848	9337
HPRD ID		05367	07225
Ensembl ID		ENSG00000111596	ENSG00000155508
Uniprot IDs		B2RDX7 B3KTL6 Q9NZN8	B0AZS3 B7Z8R1 Q9UFF9
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Gene Expression Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Silencing By RNA MRNA 3'-end Processing Gene Silencing RNA 3'-end Processing Aromatic Compound Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Positive Regulation Of MRNA Catabolic Process RNA Catabolic Process Regulation Of Stem Cell Maintenance Chromatin Organization RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Negative Regulation Of JNK Cascade Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Silencing By MiRNA Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Translation Cellular Macromolecule Catabolic Process Posttranscriptional Gene Silencing Regulation Of Cellular Protein Metabolic Process Chromosome Organization Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process MRNA Processing Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Posttranscriptional Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process MRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Phosphodiester Bond Hydrolysis Regulation Of Gene Expression RNA Processing Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway	Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA 3'-end Processing RNA 3'-end Processing Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Nuclear-transcribed MRNA Catabolic Process Regulation Of Cytoplasmic MRNA Processing Body Assembly MRNA Catabolic Process RNA Catabolic Process Gene Silencing By RNA Regulation Of Translation Gene Silencing Regulation Of Stem Cell Maintenance Positive Regulation Of Organelle Assembly RNA Phosphodiester Bond Hydrolysis, Exonucleolytic MRNA Processing Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression MRNA Metabolic Process RNA Processing Regulation Of Cell Differentiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA 3'-end Processing Regulation Of Gene Expression Trophectodermal Cell Differentiation Positive Regulation Of MRNA Catabolic Process Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Gene Silencing By MiRNA Blastocyst Formation Posttranscriptional Gene Silencing Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Component Biogenesis Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of RNA Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Catabolic Process RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Organelle Organization Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Myeloid Cell Differentiation
Tagcloud ?		11q23 12q11 12q14 12q15 12q21 17q11 17q12 3p12 6p21 6q21 6q23 9p13 9p21 acc accs adenoid amplicons ccnd3 cnas glipr1l1 mec mecs mucoepidermoid numa1 pax5 pvrl1 rab3ip sdc statuses
Tagcloud (Difference) ?		11q23 12q11 12q14 12q15 12q21 17q11 17q12 3p12 6p21 6q21 6q23 9p13 9p21 acc accs adenoid amplicons ccnd3 cnas glipr1l1 mec mecs mucoepidermoid numa1 pax5 pvrl1 rab3ip sdc statuses
Tagcloud (Intersection) ?