CNOT2 and BEX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CNOT2	BEX1
Description		CCR4-NOT transcription complex subunit 2	brain expressed X-linked 1
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane CCR4-NOT Complex CCR4-NOT Core Complex	Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	Transcription Corepressor Binding Transcription Coregulator Activity Poly(A)-specific Ribonuclease Activity Protein Binding	Transcription Coactivator Binding Signaling Receptor Binding Protein Binding Signaling Adaptor Activity Metal Ion Binding Molecular Function Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Translation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Stem Cell Population Maintenance	Signal Transduction Nervous System Development Cell Differentiation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Diastolic blood pressure ( 27841878) Ovarian cancer ( 30557369) Triglyceride levels ( 32154731)
Interacting Genes		27 interacting genes: ARMC5 BCL6 BEX1 CCHCR1 CFAP68 CIMIP1 CNOT1 CNOT3 CNOT8 CSTF2 DDB1 DSCR9 GALNT10 GCSAM GPS1 GPS2 HSF2BP MTFR1L NCOR1 NCOR2 OBI1 PRR35 PSMB4 RACK1 TBX2 TEKT3 ZFHX3	31 interacting genes: AKT1 BAG4 BCAR3 CASP8 CHEK2 CNOT2 CTAG1A CTAG1B CYSRT1 FBXW7 FGFR2 FZR1 GSK3B KLHL20 KRT31 KRT34 MAGEA2 MAGEA2B MDFI MEOX2 NGFR OMP OTP PAX2 PICK1 PIK3CA PTEN PTPN11 SMAD4 TENM1 TEX11
Entrez ID		4848	55859
HPRD ID		05367	06460
Ensembl ID		ENSG00000111596	ENSG00000133169
Uniprot IDs		B2RDX7 B3KTL6 F8VUB4 F8VV52 Q9NZN8	Q9HBH7
PDB IDs		4C0D 4C0F 5FU6 5FU7
Enriched GO Terms of Interacting Partners?		CCR4-NOT Core Complex CCR4-NOT Complex Nuclear-transcribed MRNA Poly(A) Tail Shortening Rhythmic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction GTPase Inhibitor Activity Transcription Repressor Complex Poly(A)-specific Ribonuclease Activity RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nuclear Retinoic Acid Receptor Binding Trophectodermal Cell Differentiation Negative Regulation Of Androgen Receptor Signaling Pathway Nucleus P-body Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cellular Senescence Regulation Of B Cell Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process Axonemal A Tubule Inner Sheath Negative Regulation Of MiRNA Transcription Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process MRNA Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of JNK Cascade Cyclin Binding Negative Regulation Of Cardiac Chamber Formation Histone Deacetylase Binding Negative Regulation Of Heart Looping Regulation Of Androgen Receptor Signaling Pathway Regulation Of Brood Size Outer Acrosomal Membrane Adrenal Cortex Development Negative Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process	Cellular Developmental Process Developmental Process Ubiquitin Protein Ligase Binding Positive Regulation Of Intracellular Signal Transduction Epithelial Cell Differentiation Regulation Of Intracellular Signal Transduction Cell Differentiation Positive Regulation Of Proteolysis Carbohydrate Homeostasis Positive Regulation Of Catalytic Activity Glucose Homeostasis Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Ubiquitination PML Body Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Population Proliferation Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Post-translational Protein Modification Regulation Of Catalytic Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Programmed Cell Death Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process ERBB Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Protein Modification Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of RNA Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Intracellular Glucose Homeostasis Negative Regulation Of Protein Acetylation Animal Organ Development
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