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COL6A1 and PDGFA
Number of citations of the paper that reports this interaction (PubMedID
8900172
)
0
Data Source:
BioGRID
(pull down)
COL6A1
PDGFA
Description
collagen type VI alpha 1 chain
platelet derived growth factor subunit A
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Collagen Trimer
Collagen Type VI Trimer
Basement Membrane
Mitochondrion
Lysosome
Lysosomal Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Membrane
Sarcoplasmic Reticulum
Myofibril
Extracellular Matrix
Protein-containing Complex
Sarcolemma
Extracellular Exosome
Intracellular Vesicle
Golgi Membrane
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Lumen
Microvillus
Cell Surface
Membrane
Platelet Alpha Granule Lumen
Platelet-derived Growth Factor Complex
Platelet-derived Growth Factor Receptor-ligand Complex
Molecular Function
Protein Binding
Collagen Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Platelet-derived Growth Factor Binding
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Collagen Binding
Growth Factor Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Receptor Ligand Activity
Platelet-derived Growth Factor Binding
Biological Process
Response To Reactive Oxygen Species
Cell Morphogenesis
Ossification
Osteoblast Differentiation
Hair Follicle Development
Reduction Of Food Intake In Response To Dietary Excess
Muscle System Process
Respiratory System Process
Glycolytic Process
Tricarboxylic Acid Cycle
2-oxoglutarate Metabolic Process
Energy Reserve Metabolic Process
Autophagy
Apoptotic Process
Inflammatory Response
Mitochondrion Organization
Cell Adhesion
Single Fertilization
Peripheral Nervous System Development
Heart Development
Muscle Organ Development
Skeletal Muscle Tissue Development
Circadian Rhythm
Insulin Receptor Signaling Pathway
Regulation Of Cell Size
Response To Xenobiotic Stimulus
Response To UV
Response To Wounding
Response To Mechanical Stimulus
Response To Toxic Substance
Anatomical Structure Morphogenesis
Tissue Development
Gene Expression
Muscle Cell Apoptotic Process
Response To Activity
Response To Muscle Activity
Transmission Of Nerve Impulse
Myelination In Peripheral Nervous System
Cell Differentiation
Collagen Fibril Organization
Apoptotic Nuclear Changes
Bone Mineralization
Lung Development
Response To Lipopolysaccharide
Collagen Metabolic Process
Response To Lipid
Endodermal Cell Differentiation
Limb Joint Morphogenesis
Response To Decreased Oxygen Levels
Skeletal Muscle Tissue Regeneration
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Skin Development
Insulin-like Growth Factor Receptor Signaling Pathway
Response To Pain
Lung Alveolus Development
Skeletal Muscle Tissue Growth
Skeletal Muscle Fiber Development
Tissue Remodeling
Homeostasis Of Number Of Cells
Nervous System Process
Sensory Perception Of Mechanical Stimulus
Cartilage Development
Protein Tetramerization
Neuron Apoptotic Process
Mitochondrial Depolarization
Muscle Cell Development
Uterus Development
Canonical Wnt Signaling Pathway
Bone Development
Lung Morphogenesis
Lung Epithelial Cell Differentiation
Skeletal Muscle Organ Development
Adipose Tissue Development
Muscle Structure Development
Fat Cell Proliferation
Caveola Assembly
Cellular Response To Amino Acid Stimulus
Basement Membrane Organization
Multicellular Organismal Locomotion
Reactive Oxygen Species Metabolic Process
Extracellular Matrix Assembly
Energy Homeostasis
Skeletal Muscle Fiber Differentiation
Response To Peptide
Regulation Of Collagen Fibril Organization
Response To Polyamine Macromolecule
Response To Bleomycin
Mitochondrial Transmembrane Transport
Angiogenesis
Cell Activation
Hair Follicle Development
Positive Regulation Of Mesenchymal Cell Proliferation
Cell-cell Signaling
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Response To Wounding
Animal Organ Morphogenesis
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Negative Regulation Of Platelet Activation
Regulation Of Smooth Muscle Cell Migration
Cell Projection Assembly
Actin Cytoskeleton Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Autophosphorylation
Regulation Of Actin Cytoskeleton Organization
Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Wound Healing
Positive Regulation Of MAPK Cascade
Skin Development
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Lung Alveolus Development
Digestive Tract Development
Negative Chemotaxis
Positive Regulation Of Cell Division
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Bone Development
Regulation Of Branching Involved In Salivary Gland Morphogenesis By Epithelial-mesenchymal Signaling
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Glomerular Mesangial Cell Proliferation
Embryonic Lung Development
Regulation Of DNA Biosynthetic Process
Pathways
Collagen degradation
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
ECM proteoglycans
ECM proteoglycans
NCAM1 interactions
Collagen chain trimerization
Non-integrin membrane-ECM interactions
NFE2L2 regulating tumorigenic genes
Drugs
Diseases
Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
Ossification of the posterior longitudinal ligament of spine (OPLL)
Glioma
Malignant pleural mesothelioma
GWAS
Blood protein levels (
30072576
)
Bone mineral density (lumbar spine) in inflammatory bowel disease (
29603369
)
Corneal hysteresis (
30894546
32716492
)
Corneal resistance factor (
32716492
30894546
31246245
)
Daytime nap (
33568662
)
Diverticular disease (
30177863
)
Intraocular pressure (
29235454
29617998
)
Keratoconus (
33649486
)
Low myopia (
33830181
)
Myopia (
27182965
)
Pulse pressure (
30578418
30224653
)
Refractive error (
32231278
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Systolic blood pressure (
28234671
)
Waist circumference adjusted for body mass index (
25673412
34021172
)
Male-pattern baldness (
28196072
)
Interacting Genes
15 interacting genes:
BGN
COL18A1
COL2A1
DCN
DNAJB11
FGF7
ITGAV
LAMB1
LGALS3BP
MAG
MTDH
PDGFA
PDGFB
TGM2
THBS1
17 interacting genes:
A2M
ASPH
COL1A1
COL1A2
COL2A1
COL3A1
COL4A1
COL5A1
COL6A1
DUSP3
FURIN
HSPG2
MBD3
MDFI
PDAP1
PDGFRA
SPARC
Entrez ID
1291
5154
HPRD ID
00370
01424
Ensembl ID
ENSG00000142156
ENSG00000197461
Uniprot IDs
A0A384P5H7
P12109
P04085
PDB IDs
3MJK
Enriched GO Terms of Interacting Partners
?
Extracellular Matrix
Extracellular Space
Endoplasmic Reticulum Lumen
Extracellular Matrix Binding
Platelet-derived Growth Factor Binding
Extracellular Region
Platelet-derived Growth Factor Complex
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Bone Development
Regulation Of Anatomical Structure Morphogenesis
Positive Regulation Of Metanephric Mesenchymal Cell Migration
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Golgi Lumen
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Phospholipid Biosynthetic Process
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Extracellular Matrix Structural Constituent
Anatomical Structure Formation Involved In Morphogenesis
Positive Regulation Of Protein Autophosphorylation
Regulation Of Developmental Process
Regulation Of Branching Involved In Salivary Gland Morphogenesis
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Protein Homodimerization Activity
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Angiogenesis
Regulation Of Glomerular Mesangial Cell Proliferation
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Regulation Of Vasculature Development
Regulation Of Angiogenesis
Positive Regulation Of Angiogenesis
Proteoglycan Binding
Collagen Binding
Positive Regulation Of Signal Transduction
Branching Involved In Salivary Gland Morphogenesis
Regulation Of Cell Division
Platelet Alpha Granule Lumen
Regulation Of Protein Autophosphorylation
Regulation Of Blood Coagulation
Positive Regulation Of Vasculature Development
Platelet-derived Growth Factor Receptor Binding
Regulation Of Hemostasis
Collagen Trimer
Positive Regulation Of Cell Migration
Extracellular Exosome
Positive Regulation Of Cell Motility
Regulation Of Plasminogen Activation
Response To Wounding
Positive Regulation Of Locomotion
Regulation Of Phospholipid Biosynthetic Process
Negative Regulation Of Platelet Activation
Platelet-derived Growth Factor Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Fibrillar Collagen Trimer
Extracellular Matrix Organization
Extracellular Structure Organization
Collagen Trimer
Extracellular Matrix
Extracellular Matrix Structural Constituent
Collagen Fibril Organization
Cellular Response To Amino Acid Stimulus
Basement Membrane
Response To Amino Acid
Collagen Metabolic Process
Endoplasmic Reticulum Lumen
Anatomical Structure Morphogenesis
Animal Organ Morphogenesis
Extracellular Region
Protease Binding
Animal Organ Development
Skin Development
Developmental Process
Collagen Type I Trimer
Enzyme-linked Receptor Protein Signaling Pathway
Extracellular Matrix Assembly
Cartilage Development
Face Morphogenesis
Skeletal System Morphogenesis
Basement Membrane Organization
Anatomical Structure Formation Involved In Morphogenesis
Collagen Type XI Trimer
Blood Vessel Development
Limb Joint Morphogenesis
System Development
Extracellular Space
Cell Surface Receptor Signaling Pathway
Tissue Development
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Roof Of Mouth Development
Collagen Biosynthetic Process
Skin Morphogenesis
Embryonic Skeletal System Morphogenesis
Proteoglycan Binding
Collagen-activated Signaling Pathway
Biomineral Tissue Development
Transforming Growth Factor Beta Receptor Signaling Pathway
Lung Development
Cell Differentiation
Cartilage Development Involved In Endochondral Bone Morphogenesis
Embryonic Organ Morphogenesis
Ossification
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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