ZNF579 and NR4A1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ZNF579	NR4A1
Gene Name		zinc finger protein 579	nuclear receptor subfamily 4, group A, member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	DNA Binding Poly(A) RNA Binding Metal Ion Binding	DNA Binding Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Intracellular Receptor Signaling Pathway Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Fc-epsilon Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Nuclear Receptor transcription pathway Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Generic Transcription Pathway PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR AKT phosphorylates targets in the nucleus Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: GADD45G ILK MAPK6 MEST NR4A1 OSGEP RASA1 RGS2 SF3B3 SPARC YAE1D1	83 interactors: ABCA5 ABCB11 ABCC13 ABCC6 ABCG8 AKT1 ANKIB1 ARHGEF10L ARHGEF5 ATXN1 BBS10 BCL2 BCL2A1 BCL2L10 CD2AP CDKN2D CHD1L CHD3 CHEK2 CPT1A CUTA DIABLO EP300 FAF1 FXYD3 GADD45GIP1 GK GLOD4 GLUD1 HADHA HES1 HIF1A HNRNPA2B1 HSP90AB1 KAT2B KRTAP10-1 KRTAP10-5 LONRF1 LSS MAP3K1 MAPK1 MAPK8 MED1 MED31 NACAD NCOA1 NCOA2 NCOA3 NCOR2 NFKB1 NR3C1 PGBD1 PML POLA2 PPARG PPBP PPM1A PRDX4 PRDX6 RBL1 ROBO2 RPL7 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KA6 RTN4 RXRG SERPINA4 SERPING1 SMAD3 SOCS4 STAT3 SUGT1 TCF4 TP53 TRIM28 TUBB4A VASP VHL YWHAZ ZNF331 ZNF579
Entrez ID		163033	3164
HPRD ID		11730	00744
Ensembl ID		ENSG00000218891	ENSG00000123358
Uniprot IDs		Q8NAF0	F5GXF0 P22736
PDB IDs			2QW4 3V3E 3V3Q
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Transferase Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Phosphorylation Regulation Of Endothelial Cell Proliferation Regulation Of Cell Morphogenesis Threonylcarbamoyladenosine Biosynthetic Process Regulation Of Cytoskeleton Organization Regulation Of Cell-matrix Adhesion Regulation Of Catalytic Activity Cell Cycle Regulation Of MAPK Cascade Threonylcarbamoyladenosine Metabolic Process Developmental Process Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Adrenergic Receptor Signaling Pathway Ameboidal-type Cell Migration Positive Regulation Of Catalytic Activity Regulation Of Cell Death Positive Regulation Of Cardiac Muscle Contraction Platelet Activation Regulation Of Cell-substrate Adhesion Regulation Of Protein Kinase Activity Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity Negative Regulation Of Neuron Death Activation Of MAPKKK Activity Positive Regulation Of P38MAPK Cascade Regulation Of Kinase Activity Relaxation Of Vascular Smooth Muscle Response To L-ascorbic Acid Regulation Of Intracellular Signal Transduction Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Hypertrophy Response To Lipid Regulation Of Neuron Apoptotic Process Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy Cardiovascular System Development Intracellular Signal Transduction Fibroblast Migration Extracellular Fibril Organization Response To Gravity Negative Regulation Of Apoptotic Process	Positive Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cell Death Death Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway Cellular Response To Stress Response To Stimulus Intracellular Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus DNA-templated Transcription, Initiation Response To Growth Factor Regulation Of Cell Death Signal Transduction Regulation Of Apoptotic Process Regulation Of Signaling Signaling Cellular Response To Stimulus Regulation Of Signal Transduction Cell Communication Apoptotic Signaling Pathway Response To Stress RNA Biosynthetic Process Regulation Of Intracellular Transport Epithelium Development Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Intracellular Signal Transduction Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Placenta Development Reproductive Structure Development Regulation Of Metabolic Process Reproductive System Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Toll-like Receptor TLR6:TLR2 Signaling Pathway
Tagcloud ?			1alpha adenine afterwards ant1 apoptotic associate associates autophagy bcl convert description hypoxic inner latest mim mom ngfib nur77 orphan outer proteasomal stabilization summarizes tr3 translocase translocated translocates translocon trapgamma
Tagcloud (Difference) ?			1alpha adenine afterwards ant1 apoptotic associate associates autophagy bcl convert description hypoxic inner latest mim mom ngfib nur77 orphan outer proteasomal stabilization summarizes tr3 translocase translocated translocates translocon trapgamma
Tagcloud (Intersection) ?