ZNF579 and SPARC

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		ZNF579	SPARC
Description		zinc finger protein 579	secreted protein acidic and cysteine rich
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Region Basement Membrane Extracellular Space Cytoplasm Mitochondrion Plasma Membrane Cell Surface Nuclear Matrix Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Membrane Platelet Alpha Granule Lumen Endocytic Vesicle Lumen
	Molecular Function	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Metal Ion Binding Extracellular Matrix Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Cell Morphogenesis Semicircular Canal Morphogenesis Regulation Of Synapse Organization
Pathways			Platelet degranulation Nuclear signaling by ERBB4 ECM proteoglycans Scavenging by Class H Receptors
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Periodontitis (Mean PAL) ( 24024966)	Stroke ( 32693751)
Interacting Genes		11 interacting genes: GADD45G ILK MAPK6 MEST NR4A1 OSGEP RASA1 RGS2 SF3B3 SPARC YAE1	26 interacting genes: COL11A1 COL13A1 COL18A1 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 CPEB2 CTSK FN1 HSPG2 PDGFA PDGFB PLAT PLG SDC2 TGFB1 TGM2 THBS1 TNC UBQLN1 VEGFA VHL XRCC6 ZNF579
Entrez ID		163033	6678
HPRD ID		11730	01631
Ensembl ID		ENSG00000218891	ENSG00000113140
Uniprot IDs		Q8NAF0	P09486
PDB IDs			1BMO 1NUB 1SRA 2V53
Enriched GO Terms of Interacting Partners?			Extracellular Matrix Platelet-derived Growth Factor Binding Endoplasmic Reticulum Lumen Fibrillar Collagen Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Region Extracellular Matrix Structural Constituent Collagen Trimer Platelet Alpha Granule Lumen Proteoglycan Binding Anatomical Structure Morphogenesis Extracellular Space Extracellular Matrix Organization Extracellular Structure Organization Basement Membrane Animal Organ Morphogenesis Collagen Fibril Organization Anatomical Structure Formation Involved In Morphogenesis Response To Oxygen Levels Animal Organ Development Response To Hypoxia Protease Binding Angiogenesis Response To Decreased Oxygen Levels Regulation Of Blood Vessel Endothelial Cell Migration Collagen Type XI Trimer Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Blood Coagulation Regulation Of Hemostasis Blood Vessel Development Integrin Binding Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Regulation Of Cell Motility Regulation Of Cell Adhesion Regulation Of Locomotion Platelet-derived Growth Factor Receptor Signaling Pathway Developmental Process Response To Stress Negative Regulation Of Cell Adhesion Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Response To Growth Factor Golgi Lumen Regulation Of Endothelial Cell Migration Secretory Granule Cell Migration Regulation Of Developmental Process Response To Wounding Negative Regulation Of Fibrinolysis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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