AKAP14 and PRKAR2A

Number of citations of the paper that reports this interaction (PubMedID 12475942)
45

Data Source:
HPRD (in vivo, in vitro)

		AKAP14	PRKAR2A
Description		A-kinase anchoring protein 14	protein kinase cAMP-dependent type II regulatory subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Axoneme CAMP-dependent Protein Kinase Complex	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base
	Molecular Function	Protein Binding Protein Kinase A Regulatory Subunit Binding	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process		Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction
Pathways			PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			GEM-231
Diseases
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Lipoprotein (a) levels ( 33730874) Morning person ( 30696823) Resting heart rate ( 27798624) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		8 interacting genes: DPY30 FBXO7 PRKACA PRKAR1B PRKAR2A PRKAR2B ROPN1 ROPN1L	40 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 ARFGEF2 CBFA2T3 CDK1 CFTR EZR FOS IFNAR2 LRIF1 MAP2 MYCBPAP NBEA OGT PJA2 PPP1CB PRKACA PRKX RAB32 RACK1 RET RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 WASF1 WEE2-AS1
Entrez ID		158798	5576
HPRD ID		02353	01484
Ensembl ID		ENSG00000186471	ENSG00000114302
Uniprot IDs		Q86UN6	A0A024R2W3 A0A0S2Z472 A0A9L9PY56 A8KAH7 P13861
PDB IDs			2IZX 2KYG 4ZP3 5H78 5XBY 8S8O
Enriched GO Terms of Interacting Partners?		CAMP-dependent Protein Kinase Complex Ciliary Base CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Protein Kinase A Catalytic Subunit Binding Sperm Capacitation CAMP Binding Negative Regulation Of CAMP/PKA Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Negative Regulation Of Intracellular Signal Transduction Nucleotide-activated Protein Kinase Complex Cell Maturation Developmental Maturation Motile Cilium Plasma Membrane Raft Protein Domain Specific Binding Postsynapse Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication G Protein-coupled Receptor Signaling Pathway Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Intracellular Signal Transduction Protein Kinase Binding Response To Antipsychotic Drug Modulation Of Chemical Synaptic Transmission Axoneme Lewy Body Core Sperm Motility Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Cilium Glutamatergic Synapse Centrosome CAMP-dependent Protein Kinase Activity Cilium Movement Channel Activator Activity Regulation Of Macroautophagy Positive Regulation Of Fear Response CAMP/PKA Signal Transduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress	Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Regulation Of Protein Kinase A Signaling CAMP-dependent Protein Kinase Complex Cellular Response To Oxygen-containing Compound Positive Regulation Of Intracellular Transport Response To Purine-containing Compound Response To CAMP Positive Regulation Of Transport Positive Regulation Of Protein Localization Cellular Response To CAMP Regulation Of Protein Catabolic Process Cellular Response To Glucose Stimulus Signal Transduction Regulation Of Cellular Localization Cellular Response To Carbohydrate Stimulus Intracellular Signaling Cassette Intracellular Signal Transduction Adenylate Cyclase Binding Intracellular Glucose Homeostasis Positive Regulation Of Protein Transport Regulation Of Protein Localization Protein Kinase A Catalytic Subunit Binding Regulation Of Intracellular Transport Molecular Adaptor Activity GABA Receptor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sperm Capacitation Left Ventricular Cardiac Muscle Tissue Morphogenesis Dendritic Branch Response To Glucose Positive Regulation Of Establishment Of Protein Localization Protein Kinase Binding Response To Monosaccharide Positive Regulation Of Protein Kinase A Signaling SMAD Protein Signal Transduction MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcium Channel Complex R-SMAD Binding Multicellular Organismal-level Water Homeostasis Membrane To Membrane Docking Regulation Of Multicellular Organismal Process Regulation Of Transport Response To Carbohydrate Intracellular Chemical Homeostasis Negative Regulation Of Cell Growth CAMP-dependent Protein Kinase Activity Positive Regulation Of Intracellular Protein Transport Cellular Response To Growth Factor Stimulus
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