TSTD2 and BUB1

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		TSTD2	BUB1
Description		thiosulfate sulfurtransferase like domain containing 2	BUB1 mitotic checkpoint serine/threonine kinase
Image		No pdb structure
GO Annotations	Cellular Component		Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Membrane
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity Histone H2A Kinase Activity
	Biological Process		Chromatin Remodeling Apoptotic Process Chromosome Segregation Regulation Of Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Intracellular Signal Transduction Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Chromosome Segregation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
Interacting Genes		33 interacting genes: AGR2 APC AURKA BLZF1 BUB1 CCND1 DCC EGFR FLCN IKZF1 IKZF3 INCA1 ISY1-RAB43 L3MBTL3 LHX4 MCC MEOX2 MLH3 MUTYH ODC1 PICK1 PTPRJ REL SMAD4 SSX2IP TCF4 TOX3 VPS52 ZBTB14 ZFPL1 ZNF438 ZNF774 ZRANB1	64 interacting genes: AKT1 ALDOB ANP32B AOPEP AP1B1 AP2B1 AP3B1 AP4B1 APC ARIH2 BAAT BUB3 CCDC180 CDC14B CDC20 CDK1 CDK8 CORO2A CRK CTSV CYLC2 DVL1 EIF4EBP1 FANCC FBP1 FBP2 FBXO7 FRAT2 GALNT12 HDAC1 HEMGN HRAS HSD17B3 IGFBP3 KNL1 LEF1 MAP2K1 MAPK3 MSANTD3 NANS PLK1 PPP2CB PPP3R2 RAE1 RASA1 RDH12 SEC61B SFRP2 SFRP4 SHC1 SMAD1 STX17 SVIL TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRMO TSTD2 UBC XPA ZNF189 ZNF510
Entrez ID		158427	699
HPRD ID		16679	03907
Ensembl ID		ENSG00000136925	ENSG00000169679
Uniprot IDs		Q5T7W7	B4DYG2 O43683
PDB IDs			2LAH 4A1G 4QPM 4R8Q 5DMZ 6F7B 7B1F 7B1H 7B1J
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Regulation Of Programmed Cell Death Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II DNA Binding Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mesoderm Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Cyclin-dependent Protein Kinase Activity Regulation Of Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Phosphate Metabolic Process Gamma-catenin Binding Response To UV-A Regulation Of RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cardiocyte Differentiation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cellular Component Organization Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Kinase Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of ERBB Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Kinase Activity Cellular Developmental Process Protein-containing Complex Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Developmental Process Digestive Tract Morphogenesis Regulation Of Cell Population Proliferation Negative Regulation Of Protein Metabolic Process Neuron Projection Guidance Axon Guidance Ruffle Membrane Heart Valve Development Beta-catenin Binding Animal Organ Development Negative Regulation Of Protein Phosphorylation Negative Regulation Of Metabolic Process	Clathrin Adaptor Complex Regulation Of Organelle Organization Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Membrane Coat Cytosol Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Fructose 1,6-bisphosphate Metabolic Process Regulation Of Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cytoskeleton Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Canonical Wnt Signaling Pathway Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Separation Regulation Of Chromosome Segregation Insulin Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Protein Localization To Kinetochore Positive Regulation Of Ubiquitin-protein Transferase Activity Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Golgi Inheritance Negative Regulation Of Mitotic Nuclear Division Intracellular Signal Transduction Fructose Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Localization Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Cell Projection Organization Regulation Of Chromosome Organization Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Protein Localization To Membrane Gluconeogenesis Schwann Cell Development Negative Regulation Of Cell Cycle
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