TSTD2 and FLCN

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		TSTD2	FLCN
Description		thiosulfate sulfurtransferase like domain containing 2	folliculin
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Cytoplasm Lysosome Lysosomal Membrane Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Midbody Cell Projection Cell-cell Contact Zone Mitotic Spindle FNIP-folliculin RagC/D GAP
	Molecular Function	Protein Binding	Enzyme Inhibitor Activity GTPase Activator Activity Protein Binding Enzyme Binding Protein-containing Complex Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Lysosome Organization Cell-cell Junction Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Autophagy Hemopoiesis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Cellular Response To Nutrient Levels TOR Signaling Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Lysosome Localization Cellular Response To Amino Acid Starvation Negative Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction TORC1 Signaling Positive Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Regulation Of Ras Protein Signal Transduction Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Cell Proliferation Involved In Kidney Development Energy Homeostasis Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Brown Fat Cell Differentiation Positive Regulation Of TORC1 Signaling Negative Regulation Of Lysosome Organization Regulation Of Pro-B Cell Differentiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Amino acids regulate mTORC1
Drugs
Diseases			Birt-Hogg-Dube syndrome Renal cell carcinoma
GWAS			Heel bone mineral density ( 30598549) Mean reticulocyte volume ( 32888494)
Interacting Genes		33 interacting genes: AGR2 APC AURKA BLZF1 BUB1 CCND1 DCC EGFR FLCN IKZF1 IKZF3 INCA1 ISY1-RAB43 L3MBTL3 LHX4 MCC MEOX2 MLH3 MUTYH ODC1 PICK1 PTPRJ REL SMAD4 SSX2IP TCF4 TOX3 VPS52 ZBTB14 ZFPL1 ZNF438 ZNF774 ZRANB1	12 interacting genes: ALDOB APP CCDC180 FBP1 GABARAP HEMGN HSP90AA1 MAP1LC3B NANS RRAGA TMEFF1 TSTD2
Entrez ID		158427	201163
HPRD ID		16679	06278
Ensembl ID		ENSG00000136925	ENSG00000154803
Uniprot IDs		Q5T7W7	A0A0S2Z5Y7 Q8NFG4
PDB IDs			3V42 6NZD 6ULG 8DHB
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Regulation Of Programmed Cell Death Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II DNA Binding Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mesoderm Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Cyclin-dependent Protein Kinase Activity Regulation Of Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Phosphate Metabolic Process Gamma-catenin Binding Response To UV-A Regulation Of RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cardiocyte Differentiation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cellular Component Organization Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Kinase Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of ERBB Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Kinase Activity Cellular Developmental Process Protein-containing Complex Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Developmental Process Digestive Tract Morphogenesis Regulation Of Cell Population Proliferation Negative Regulation Of Protein Metabolic Process Neuron Projection Guidance Axon Guidance Ruffle Membrane Heart Valve Development Beta-catenin Binding Animal Organ Development Negative Regulation Of Protein Phosphorylation Negative Regulation Of Metabolic Process	Fructose Metabolic Process Regulation Of Carbohydrate Catabolic Process Fructose 1,6-bisphosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Ubiquitin Protein Ligase Binding Autophagosome Organization Autophagosome Assembly Phosphatidylethanolamine Binding Cellular Response To Nitrogen Starvation Carbohydrate Biosynthetic Process Response To Salt Stress Regulation Of Generation Of Precursor Metabolites And Energy Vacuole Organization Response To Nutrient Levels Cellular Response To Starvation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Gluconeogenesis Hexose Biosynthetic Process Fructose-1-phosphate Aldolase Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP CTP Binding DATP Binding Response To Starvation Cellular Response To Nutrient Levels Autophagosome Membrane Autophagosome Maturation N-acetylneuraminate Synthase Activity N-acylneuraminate-9-phosphate Synthase Activity Mitophagy Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Autophagy Regulation Of Small Molecule Metabolic Process Negative Regulation Of Pentose-phosphate Shunt Acetylcholine Receptor Activator Activity Regulation Of ATP Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Response To Osmotic Stress Phosphoric Ester Hydrolase Activity Cellular Response To Raffinose Fructose 1,6-bisphosphate 1-phosphatase Activity
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