MAP3K20 and ZNF593

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAP3K20	ZNF593
Description		mitogen-activated protein kinase kinase kinase 20	zinc finger protein 593
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity RRNA Binding Protein Kinase Regulator Activity Protein Kinase Activator Activity Ribosome Binding Metal Ion Binding Small Ribosomal Subunit RRNA Binding Protein Serine Kinase Activity Stalled Ribosome Sensor Activity	Nucleic Acid Binding DNA Binding Protein Binding Zinc Ion Binding Ribonucleoprotein Complex Binding Metal Ion Binding Preribosome Binding
	Biological Process	DNA Damage Checkpoint Signaling MAPK Cascade Translational Initiation Protein Phosphorylation Inflammatory Response Cytoskeleton Organization Chromosome Segregation JNK Cascade Cell Death Regulation Of Mitotic Metaphase/anaphase Transition Cell Differentiation Stress-activated Protein Kinase Signaling Cascade Intracellular Signal Transduction P38MAPK Cascade Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Autophosphorylation Stress-activated MAPK Cascade Protein Maturation Limb Development Pyroptotic Inflammatory Response Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Cellular Response To Gamma Radiation Cellular Response To UV-B GCN2-mediated Signaling Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Mitotic DNA Damage Checkpoint NLRP1 Inflammasome Complex Assembly	Ribosome Biogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Pathways
Drugs		Dasatinib Fostamatinib
Diseases
GWAS		Haemorrhoidal disease ( 33888516)
Interacting Genes		29 interacting genes: CCDC69 CRMP1 DDAH2 EZH2 IGHM ITSN1 MAP2K4 MAP2K6 MAP2K7 MIDN MPP1 NEDD4L RBX1 RNF19A RPS6KA5 SMARCB1 SRPK2 TGFBR1 UNC119 VPS33B YWHAG YWHAZ ZFP2 ZNF33A ZNF567 ZNF593 ZNF660 ZNF746 ZNF775	10 interacting genes: DDIT4L GPR3 LNX1 MAP3K20 MAP3K7 MAPK8IP2 PICK1 POLR1H RAB1A SRPK2
Entrez ID		51776	51042
HPRD ID		11791	15866
Ensembl ID		ENSG00000091436	ENSG00000142684
Uniprot IDs		D4Q8H0 Q9NYL2	O00488
PDB IDs		5HES 5X5O 6JUT 6JUU 7YAW 7YAZ	1ZR9 6LSS 6LU8 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8IDT 8IDY 8IE3 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR3 8RL2
Enriched GO Terms of Interacting Partners?		Regulation Of Caveolin-mediated Endocytosis MAP Kinase Kinase Activity JUN Kinase Kinase Activity TORC1 Signaling Regulation Of Metabolic Process TOR Signaling Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Primary Metabolic Process MAPK Cascade Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Regulation Of Synapse Organization Regulation Of RNA Metabolic Process Nucleus Protein Kinase Activity Cellular Senescence Protein Modification Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of TORC1 Signaling Molecular Adaptor Activity Protein Serine Kinase Activity Regulation Of Motor Neuron Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transferase Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Kinase Activity Intracellular Signal Transduction Negative Regulation Of TOR Signaling Regulation Of Macromolecule Biosynthetic Process Regulation Of TORC1 Signaling Stress-activated MAPK Cascade Fc-epsilon Receptor Signaling Pathway Stress-activated Protein Kinase Signaling Cascade P38MAPK Cascade Regulation Of Kinase Activity Spindle Midzone Blastocyst Development Hepatocyte Homeostasis Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Histone H2AS1 Kinase Activity Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Regulation Of Postsynapse Organization Protein Metabolic Process	JNK Cascade Phosphorylation Protein Phosphorylation P38MAPK Cascade Stress-activated MAPK Cascade MAP Kinase Kinase Kinase Activity Stress-activated Protein Kinase Signaling Cascade Magnesium Ion Binding Regulation Of Stress-activated Protein Kinase Signaling Cascade Protein Kinase Activator Activity MAPK Cascade Positive Regulation Of Mitotic DNA Damage Checkpoint Mannosyltransferase Complex Defense Response Phosphate-containing Compound Metabolic Process Positive Regulation Of Cell Cycle Protein Serine Kinase Activity Alpha-1,6-mannosyltransferase Activity Intracellular Signaling Cassette Protein Serine/threonine Kinase Activity Negative Regulation Of Signaling I-kappaB Phosphorylation Linear Polyubiquitin Binding Negative Regulation Of Cell Communication Termination Of RNA Polymerase I Transcription Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress GPI Mannosyltransferase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?