MAP3K20 and CCDC69

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAP3K20	CCDC69
Description		mitogen-activated protein kinase kinase kinase 20	coiled-coil domain containing 69
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm Spindle Cytoskeleton Midbody Spindle Midzone
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity RRNA Binding Protein Kinase Regulator Activity Protein Kinase Activator Activity Ribosome Binding Metal Ion Binding Small Ribosomal Subunit RRNA Binding Protein Serine Kinase Activity Stalled Ribosome Sensor Activity	Microtubule Binding
	Biological Process	DNA Damage Checkpoint Signaling MAPK Cascade Translational Initiation Protein Phosphorylation Inflammatory Response Cytoskeleton Organization Chromosome Segregation JNK Cascade Cell Death Regulation Of Mitotic Metaphase/anaphase Transition Cell Differentiation Stress-activated Protein Kinase Signaling Cascade Intracellular Signal Transduction P38MAPK Cascade Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Autophosphorylation Stress-activated MAPK Cascade Protein Maturation Limb Development Pyroptotic Inflammatory Response Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Cellular Response To Gamma Radiation Cellular Response To UV-B GCN2-mediated Signaling Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Mitotic DNA Damage Checkpoint NLRP1 Inflammasome Complex Assembly	Spindle Midzone Assembly
Pathways
Drugs		Dasatinib Fostamatinib
Diseases
GWAS		Haemorrhoidal disease ( 33888516)	Bulimia nervosa ( 23568457) Chronic obstructive pulmonary disease ( 30804561) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Loneliness (linear analysis) ( 27629369) Lymphocyte count ( 32888494) Monocyte count ( 27863252 32888494) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Red cell distribution width ( 32888494) White blood cell count ( 27863252 32888494)
Interacting Genes		29 interacting genes: CCDC69 CRMP1 DDAH2 EZH2 IGHM ITSN1 MAP2K4 MAP2K6 MAP2K7 MIDN MPP1 NEDD4L RBX1 RNF19A RPS6KA5 SMARCB1 SRPK2 TGFBR1 UNC119 VPS33B YWHAG YWHAZ ZFP2 ZNF33A ZNF567 ZNF593 ZNF660 ZNF746 ZNF775	5 interacting genes: ACO1 MAP3K1 MAP3K20 PSMA3 SMURF1
Entrez ID		51776	26112
HPRD ID		11791	13152
Ensembl ID		ENSG00000091436	ENSG00000198624
Uniprot IDs		D4Q8H0 Q9NYL2	A6NI79 Q7L2X4
PDB IDs		5HES 5X5O 6JUT 6JUU 7YAW 7YAZ
Enriched GO Terms of Interacting Partners?		Regulation Of Caveolin-mediated Endocytosis MAP Kinase Kinase Activity JUN Kinase Kinase Activity TORC1 Signaling Regulation Of Metabolic Process TOR Signaling Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Primary Metabolic Process MAPK Cascade Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Regulation Of Synapse Organization Regulation Of RNA Metabolic Process Nucleus Protein Kinase Activity Cellular Senescence Protein Modification Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of TORC1 Signaling Molecular Adaptor Activity Protein Serine Kinase Activity Regulation Of Motor Neuron Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transferase Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Kinase Activity Intracellular Signal Transduction Negative Regulation Of TOR Signaling Regulation Of Macromolecule Biosynthetic Process Regulation Of TORC1 Signaling Stress-activated MAPK Cascade Fc-epsilon Receptor Signaling Pathway Stress-activated Protein Kinase Signaling Cascade P38MAPK Cascade Regulation Of Kinase Activity Spindle Midzone Blastocyst Development Hepatocyte Homeostasis Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Histone H2AS1 Kinase Activity Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Regulation Of Postsynapse Organization Protein Metabolic Process	MAP Kinase Kinase Kinase Activity 3 Iron, 4 Sulfur Cluster Binding Citrate Metabolic Process Negative Regulation Of Translation Aconitate Hydratase Activity Iron-responsive Element Binding GCN2-mediated Signaling Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Stalled Ribosome Sensor Activity Positive Regulation Of Mitotic DNA Damage Checkpoint Engulfment Of Target By Autophagosome Positive Regulation Of DNA Damage Checkpoint Phosphate-containing Compound Metabolic Process MRNA Regulatory Element Binding Translation Repressor Activity Response To Iron(II) Ion NADPH Regeneration Tricarboxylic Acid Metabolic Process Cytosol Protein Serine/threonine Kinase Activity MAPK Cascade Phosphorylation Protein Phosphorylation Protein Metabolic Process Protein Serine Kinase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasome Core Complex, Alpha-subunit Complex Regulation Of Translation In Response To Endoplasmic Reticulum Stress Protein Kinase Regulator Activity Cellular Response To UV-B JUN Kinase Kinase Kinase Activity Negative Regulation Of Translation In Response To Stress Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Small Ribosomal Subunit RRNA Binding NLRP1 Inflammasome Complex Assembly Positive Regulation Of Cell Cycle Checkpoint Activin Receptor Binding I-SMAD Binding Protein Targeting To Vacuole Involved In Autophagy Ectoderm Development Negative Regulation Of Activin Receptor Signaling Pathway Substrate Localization To Autophagosome Transforming Growth Factor Beta Receptor Binding Regulation Of Translation Proteasome Core Complex Receptor Catabolic Process Positive Regulation Of Dendrite Extension Regulation Of Protein Metabolic Process Protein Modification Process Fc-epsilon Receptor Signaling Pathway Proteasomal Protein Catabolic Process
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