MAP3K20 and RNF19A

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAP3K20	RNF19A
Description		mitogen-activated protein kinase kinase kinase 20	ring finger protein 19A, RBR E3 ubiquitin protein ligase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Ubiquitin Ligase Complex Cytoplasm Centrosome Cytosol Cytoskeleton Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity RRNA Binding Protein Kinase Regulator Activity Protein Kinase Activator Activity Ribosome Binding Metal Ion Binding Small Ribosomal Subunit RRNA Binding Protein Serine Kinase Activity Stalled Ribosome Sensor Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Damage Checkpoint Signaling MAPK Cascade Translational Initiation Protein Phosphorylation Inflammatory Response Cytoskeleton Organization Chromosome Segregation JNK Cascade Cell Death Regulation Of Mitotic Metaphase/anaphase Transition Cell Differentiation Stress-activated Protein Kinase Signaling Cascade Intracellular Signal Transduction P38MAPK Cascade Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Autophosphorylation Stress-activated MAPK Cascade Protein Maturation Limb Development Pyroptotic Inflammatory Response Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Cellular Response To Gamma Radiation Cellular Response To UV-B GCN2-mediated Signaling Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Mitotic DNA Damage Checkpoint NLRP1 Inflammasome Complex Assembly	Microtubule Cytoskeleton Organization Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Dasatinib Fostamatinib
Diseases
GWAS		Haemorrhoidal disease ( 33888516)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Atrioventricular conduction ( 21041692) Recurrent major depressive disorder ( 29317602)
Interacting Genes		29 interacting genes: CCDC69 CRMP1 DDAH2 EZH2 IGHM ITSN1 MAP2K4 MAP2K6 MAP2K7 MIDN MPP1 NEDD4L RBX1 RNF19A RPS6KA5 SMARCB1 SRPK2 TGFBR1 UNC119 VPS33B YWHAG YWHAZ ZFP2 ZNF33A ZNF567 ZNF593 ZNF660 ZNF746 ZNF775	17 interacting genes: C11orf58 CASR ILK MAP3K20 MAP3K7 NUDT21 RPS6KA5 SNCAIP SOD1 SUFU TUBG1 TUBG2 UBE2D2 UBE2E2 UBE2L3 UBE2L6 VCP
Entrez ID		51776	25897
HPRD ID		11791	06176
Ensembl ID		ENSG00000091436	ENSG00000034677
Uniprot IDs		D4Q8H0 Q9NYL2	Q9NV58
PDB IDs		5HES 5X5O 6JUT 6JUU 7YAW 7YAZ
Enriched GO Terms of Interacting Partners?		Regulation Of Caveolin-mediated Endocytosis MAP Kinase Kinase Activity JUN Kinase Kinase Activity TORC1 Signaling Regulation Of Metabolic Process TOR Signaling Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Primary Metabolic Process MAPK Cascade Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Regulation Of Synapse Organization Regulation Of RNA Metabolic Process Nucleus Protein Kinase Activity Cellular Senescence Protein Modification Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of TORC1 Signaling Molecular Adaptor Activity Protein Serine Kinase Activity Regulation Of Motor Neuron Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transferase Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Kinase Activity Intracellular Signal Transduction Negative Regulation Of TOR Signaling Regulation Of Macromolecule Biosynthetic Process Regulation Of TORC1 Signaling Stress-activated MAPK Cascade Fc-epsilon Receptor Signaling Pathway Stress-activated Protein Kinase Signaling Cascade P38MAPK Cascade Regulation Of Kinase Activity Spindle Midzone Blastocyst Development Hepatocyte Homeostasis Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Histone H2AS1 Kinase Activity Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Regulation Of Postsynapse Organization Protein Metabolic Process	Ubiquitin Conjugating Enzyme Activity Nucleotide Binding Microtubule Nucleator Activity Mitotic Spindle Organization ISG15 Transferase Activity Microtubule Cytoskeleton Organization Involved In Mitosis ISG15-protein Conjugation Spindle Organization ATP Binding JNK Cascade Magnesium Ion Binding Gamma-tubulin Ring Complex Gamma-tubulin Complex Protein Modification Process Ubiquitin-protein Transferase Activity Post-translational Protein Modification Nucleus Ubiquitin Protein Ligase Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Ubiquitin-like Protein Transferase Activity Stress-activated MAPK Cascade MAP Kinase Kinase Kinase Activity Meiotic Spindle Organization Pericentriolar Material Cytoskeleton Organization Protein Ubiquitination P38MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Interleukin-1-mediated Signaling Pathway Chromosome Segregation Proteolysis Involved In Protein Catabolic Process Microtubule Nucleation Protein Exit From Endoplasmic Reticulum Protein Modification By Small Protein Conjugation Positive Regulation Of Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Negative Regulation Of Smoothened Signaling Pathway Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Protein K11-linked Ubiquitination Protein Kinase Binding Identical Protein Binding Microtubule Cytoskeleton Organization Microtubule-based Process Transferase Activity Spindle Microtubule Flavin Adenine Dinucleotide Catabolic Process Histone H2AS1 Kinase Activity
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