ADAM10 and EPHA3

Number of citations of the paper that reports this interaction (PMID 16239146)
79

Data Source:
HPRD (in vitro)

		ADAM10	EPHA3
Gene Name		ADAM metallopeptidase domain 10	EPH receptor A3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Golgi-associated Vesicle Plasma Membrane Focal Adhesion Cell Surface Postsynaptic Density Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome Perinuclear Endoplasmic Reticulum Tetraspanin-enriched Microdomain	Extracellular Region Early Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Receptor Binding Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding Protein Kinase Binding Protein Homodimerization Activity	GPI-linked Ephrin Receptor Activity Protein Binding ATP Binding
	Biological Process	In Utero Embryonic Development Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing Integrin-mediated Signaling Pathway Cell-cell Signaling Axon Guidance Positive Regulation Of Cell Proliferation Positive Regulation Of T Cell Chemotaxis Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Tumor Necrosis Factor Monocyte Activation Ephrin Receptor Signaling Pathway PMA-inducible Membrane Protein Ectodomain Proteolysis Constitutive Protein Ectodomain Proteolysis	Cell Adhesion Axon Guidance Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Rho GTPase Activity Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Signaling Pathway Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Retinoic Acid Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Degradation of the extracellular matrix Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Collagen degradation Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Signaling by EGFR Signaling by EGFR in Cancer Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS			Orofacial clefts ( 22863734)
Protein-Protein Interactions		7 interactors: AXL DLL1 EFNA1 EFNA2 EPHA3 SH3D19 TGFA	20 interactors: ABL1 ADAM10 CDKN2A CRK EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 FYN PIM1 RBM18 RUFY1 RUFY2 SRC SRPK1 STAT3 TP53
Entrez ID		102	2042
HPRD ID		03723	01555
Ensembl ID		ENSG00000137845	ENSG00000044524
Uniprot IDs		B4DU28 O14672	C9JXA2 P29320 Q6P4R6
PDB IDs		1M1I	2GSF 2QO2 2QO7 2QO9 2QOB 2QOC 2QOD 2QOF 2QOI 2QOK 2QOL 2QON 2QOO 2QOQ 3DZQ 3FXX 3FY2 4G2F 4GK2 4GK3 4GK4
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Ephrin Receptor Signaling Pathway Anatomical Structure Morphogenesis Generation Of Neurons Cell Morphogenesis Involved In Differentiation Neurogenesis Cell Surface Receptor Signaling Pathway Cell Development Substrate Adhesion-dependent Cell Spreading Regulation Of Epithelial To Mesenchymal Transition Cell Morphogenesis Axon Guidance Nervous System Development System Development Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Axonogenesis Regulation Of Signal Transduction Multicellular Organismal Development Regulation Of Neuron Differentiation Axon Development Anatomical Structure Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Tissue Remodeling Chemotaxis Organ Development Regulation Of Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Auditory Receptor Cell Differentiation Hemopoiesis Regulation Of Signaling Neuron Projection Morphogenesis Signal Transduction Activation Of MAPK Activity Immune System Development Regulation Of Neurogenesis Negative Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Intracellular Signal Transduction Developmental Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Differentiation Response To External Stimulus Signaling Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cell Communication	Ephrin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Differentiation Neuron Projection Development Cell Projection Morphogenesis Generation Of Neurons Cell Part Morphogenesis Neurogenesis Neuron Development Cell Development Cell Morphogenesis Movement Of Cell Or Subcellular Component Cell Projection Organization Locomotion Nervous System Development Response To External Stimulus Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway Cell Differentiation Signal Transduction Developmental Process Regulation Of Cell Adhesion Signaling Cell Communication Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Phosphorylation Multicellular Organismal Development Regulation Of Cell-cell Adhesion Regulation Of Cellular Component Organization Anatomical Structure Development Regulation Of Cell Proliferation Regulation Of Protein Phosphorylation System Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Cell Cycle Positive Regulation Of Phosphorylation
Tagcloud ?		actually ameliorating amyloidogenic appswe bace1 behavioral concept copyright deficits dramatic highlights hyperphosphorylation interpretation jnk modifying neuropathology plaque potently powerfully preclinical protected ps1 ps1de9 reserved rights secretase slow sp600125 vehicle	arid2 asxl3 cdkn2a clonal clone dipyrimidine driver extension founding geographic hypermutator lacked mel9 melanoma mll2 nras phosphatases ptprb ptprd ptprt rb1 signature strikingly subclonal subclones suppressors transitions truncation wgs
Tagcloud (Difference) ?		actually ameliorating amyloidogenic appswe bace1 behavioral concept copyright deficits dramatic highlights hyperphosphorylation interpretation jnk modifying neuropathology plaque potently powerfully preclinical protected ps1 ps1de9 reserved rights secretase slow sp600125 vehicle	arid2 asxl3 cdkn2a clonal clone dipyrimidine driver extension founding geographic hypermutator lacked mel9 melanoma mll2 nras phosphatases ptprb ptprd ptprt rb1 signature strikingly subclonal subclones suppressors transitions truncation wgs
Tagcloud (Intersection) ?