ADAM10 and AXL

Number of citations of the paper that reports this interaction (PMID 7822279)
26

Data Source:
HPRD (in vivo)

		ADAM10	AXL
Gene Name		ADAM metallopeptidase domain 10	AXL receptor tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Golgi-associated Vesicle Plasma Membrane Focal Adhesion Cell Surface Postsynaptic Density Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome Perinuclear Endoplasmic Reticulum Tetraspanin-enriched Microdomain	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Receptor Binding Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding Protein Kinase Binding Protein Homodimerization Activity	Phosphatidylserine Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Myosin Heavy Chain Binding Phosphatidylinositol 3-kinase Binding Protein Heterodimerization Activity
	Biological Process	In Utero Embryonic Development Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing Integrin-mediated Signaling Pathway Cell-cell Signaling Axon Guidance Positive Regulation Of Cell Proliferation Positive Regulation Of T Cell Chemotaxis Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Tumor Necrosis Factor Monocyte Activation Ephrin Receptor Signaling Pathway PMA-inducible Membrane Protein Ectodomain Proteolysis Constitutive Protein Ectodomain Proteolysis	Neuron Migration Natural Killer Cell Differentiation Positive Regulation Of Cytokine-mediated Signaling Pathway Blood Vessel Remodeling Phagocytosis Inflammatory Response Signal Transduction Spermatogenesis Peptidyl-tyrosine Phosphorylation Forebrain Cell Migration Platelet Activation Organ Regeneration Cellular Response To Extracellular Stimulus Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Secretion By Cell Erythrocyte Homeostasis Substrate Adhesion-dependent Cell Spreading Cellular Response To Interferon-alpha Ovulation Cycle Apoptotic Cell Clearance Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Negative Regulation Of Lymphocyte Activation Positive Regulation Of Protein Kinase B Signaling Vagina Development Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Dendritic Cell Differentiation Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Degradation of the extracellular matrix Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Collagen degradation Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Signaling by EGFR Signaling by EGFR in Cancer Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants	Signaling by VEGF VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: AXL DLL1 EFNA1 EFNA2 EPHA3 SH3D19 TGFA	21 interactors: ADAM10 CBL FBXO25 GAS6 GRB2 IL15RA IL2RG LCK NCK2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 RANBP9 SHC1 SHC3 SOCS1 SRC TNS2 TYRO3
Entrez ID		102	558
HPRD ID		03723	00171
Ensembl ID		ENSG00000137845	ENSG00000167601
Uniprot IDs		B4DU28 O14672	M0R0W6 P30530
PDB IDs		1M1I	2C5D
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Ephrin Receptor Signaling Pathway Anatomical Structure Morphogenesis Generation Of Neurons Cell Morphogenesis Involved In Differentiation Neurogenesis Cell Surface Receptor Signaling Pathway Cell Development Substrate Adhesion-dependent Cell Spreading Regulation Of Epithelial To Mesenchymal Transition Cell Morphogenesis Axon Guidance Nervous System Development System Development Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Axonogenesis Regulation Of Signal Transduction Multicellular Organismal Development Regulation Of Neuron Differentiation Axon Development Anatomical Structure Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Tissue Remodeling Chemotaxis Organ Development Regulation Of Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Auditory Receptor Cell Differentiation Hemopoiesis Regulation Of Signaling Neuron Projection Morphogenesis Signal Transduction Activation Of MAPK Activity Immune System Development Regulation Of Neurogenesis Negative Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Intracellular Signal Transduction Developmental Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Differentiation Response To External Stimulus Signaling Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cell Communication	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Leukocyte Migration Cellular Response To Growth Factor Stimulus Response To Growth Factor Blood Coagulation Hemostasis Cellular Response To Organic Substance Response To Peptide Hormone Cellular Response To Organonitrogen Compound Locomotion Response To Organic Substance Response To Peptide Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Cellular Response To Insulin Stimulus Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus Cell Migration Wound Healing Movement Of Cell Or Subcellular Component Insulin Receptor Signaling Pathway Fc Receptor Signaling Pathway Signal Transduction Cell Motility Response To Insulin Response To Wounding Regulation Of Phosphorylation Immune System Process Signaling Platelet Activation Cell Communication Regulation Of Kinase Activity Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Fc-epsilon Receptor Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Immune Response Positive Regulation Of Immune System Process
Tagcloud ?		actually ameliorating amyloidogenic appswe bace1 behavioral concept copyright deficits dramatic highlights hyperphosphorylation interpretation jnk modifying neuropathology plaque potently powerfully preclinical protected ps1 ps1de9 reserved rights secretase slow sp600125 vehicle	antiapoptotic ark augmented ax1 cascades coincubation erk forebrain gas6 gn10 gnrh gt1 mek migrating olfactory pd98059 phosphoinositide pi3 postmigratory programmed protects rescued starved threonine tyro7 ufo windows withdrawal wortmannin
Tagcloud (Difference) ?		actually ameliorating amyloidogenic appswe bace1 behavioral concept copyright deficits dramatic highlights hyperphosphorylation interpretation jnk modifying neuropathology plaque potently powerfully preclinical protected ps1 ps1de9 reserved rights secretase slow sp600125 vehicle	antiapoptotic ark augmented ax1 cascades coincubation erk forebrain gas6 gn10 gnrh gt1 mek migrating olfactory pd98059 phosphoinositide pi3 postmigratory programmed protects rescued starved threonine tyro7 ufo windows withdrawal wortmannin
Tagcloud (Intersection) ?