CTNNB1 and CHUK

Number of citations of the paper that reports this interaction (PubMedID 12589056)
79

Data Source:
BioGRID (pull down, enzymatic study)
HPRD (in vitro, in vivo)

		CTNNB1	CHUK
Description		catenin beta 1	component of inhibitor of nuclear factor kappa B kinase complex
Image
GO Annotations	Cellular Component	Euchromatin Spindle Pole Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Fascia Adherens Bicellular Tight Junction Focal Adhesion Cilium Cell Cortex Intercalated Disc Membrane Basolateral Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Flotillin Complex Z Disc Lamellipodium Cell Junction Beta-catenin Destruction Complex Cell Projection Membrane Microvillus Membrane Protein-containing Complex Protein-DNA Complex Scrib-APC-beta-catenin Complex Ciliary Basal Body Presynaptic Membrane Cell Projection Apical Junction Complex Apical Part Of Cell Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Beta-catenin-TCF7L2 Complex Catenin-TCF7L2 Complex Cell Periphery RNA Polymerase II Transcription Regulator Complex Schaffer Collateral - CA1 Synapse Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse Postsynaptic Density, Intracellular Component Beta-catenin-ICAT Complex Beta-catenin-TCF Complex Wnt Signalosome	Nucleus Nucleoplasm Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex
	Molecular Function	Transcription Coregulator Binding Transcription Corepressor Binding Chromatin Binding Transcription Coactivator Activity Signaling Receptor Binding Protein Binding Nuclear Receptor Binding Enzyme Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Protein Phosphatase Binding Nuclear Estrogen Receptor Binding Ubiquitin Protein Ligase Binding Transmembrane Transporter Binding Alpha-catenin Binding Cadherin Binding SMAD Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding I-SMAD Binding Disordered Domain Specific Binding DNA-binding Transcription Factor Binding Histone Methyltransferase Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Kinase Activity Transferase Activity Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity Scaffold Protein Binding Transferrin Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Protein Polyubiquitination Embryonic Axis Specification Cell Morphogenesis Skeletal System Development Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Osteoblast Differentiation Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Endoderm Formation Cell Fate Specification Endodermal Cell Fate Commitment Neuron Migration Kidney Development Epithelial To Mesenchymal Transition Neural Plate Development Tissue Homeostasis Vasculature Development Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Lens Morphogenesis In Camera-type Eye Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Metanephros Morphogenesis Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell Adhesion Cell-matrix Adhesion Epidermal Growth Factor Receptor Signaling Pathway Chemical Synaptic Transmission Ectoderm Development Nervous System Development Glial Cell Fate Determination Neuroblast Proliferation Heart Development Intracellular Protein Localization Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Xenobiotic Stimulus Anterior/posterior Axis Specification Dorsal/ventral Axis Specification Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Mesenchymal Cell Proliferation Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Wnt Signaling Pathway Morphogenesis Of Embryonic Epithelium Negative Regulation Of Angiogenesis Stem Cell Population Maintenance Layer Formation In Cerebral Cortex Hypothalamus Development Central Nervous System Vasculogenesis Hair Cycle Process Hemopoiesis Cell Differentiation Neuron Differentiation T Cell Differentiation Osteoclast Differentiation Lung Development Male Genitalia Development Epithelial Cell Differentiation Regulation Of Epithelial Cell Differentiation Positive Regulation Of Epithelial Cell Differentiation Forebrain Development Midbrain Development Hindbrain Development Regulation Of Centriole-centriole Cohesion Pancreas Development Hair Follicle Morphogenesis Regulation Of Protein Ubiquitination Regulation Of Myelination Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Transcription Elongation By RNA Polymerase II T Cell Differentiation In Thymus Negative Regulation Of Protein Sumoylation Positive Regulation Of Homotypic Cell-cell Adhesion Adherens Junction Organization Adherens Junction Assembly Protein Localization To Cell Surface Embryonic Heart Tube Development Genitalia Morphogenesis Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Hair Cell Differentiation Detection Of Muscle Stretch Embryonic Skeletal Limb Joint Morphogenesis Astrocyte-dopaminergic Neuron Signaling Regulation Of Cell Population Proliferation Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Skin Development Cell-cell Adhesion Mediated By Cadherin Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Bone Resorption Regulation Of Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Fibroblast Proliferation Cell Maturation Synaptic Vesicle Transport Animal Organ Development Thymus Development Embryonic Organ Development Oocyte Development Embryonic Foregut Morphogenesis Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Determination Oligodendrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Neurogenesis Negative Regulation Of Neurogenesis Synapse Organization Detection Of Mechanical Stimulus Smooth Muscle Cell Differentiation Myoblast Proliferation Regulation Of Timing Of Anagen Regulation Of Synapse Assembly Oviduct Development Canonical Wnt Signaling Pathway Limb Development Mesenchymal To Epithelial Transition Trachea Morphogenesis Trachea Formation Epithelial Tube Branching Involved In Lung Morphogenesis Lung Cell Differentiation Lung-associated Mesenchyme Development Lung Epithelial Cell Differentiation Lung Induction Epithelial Cell Differentiation Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Hair Follicle Placode Formation Establishment Of Blood-brain Barrier Mesenchymal Cell Proliferation Involved In Lung Development Positive Regulation Of Branching Involved In Lung Morphogenesis Endothelial Tube Morphogenesis Fungiform Papilla Formation Sympathetic Ganglion Development Cranial Ganglion Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Growth Factor Stimulus Cellular Response To Indole-3-methanol Renal Vesicle Formation Renal Inner Medulla Development Renal Outer Medulla Development Nephron Tubule Formation Stem Cell Proliferation Regulation Of Nephron Tubule Epithelial Cell Differentiation Mesenchymal Stem Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Calcium Ion Import Acinar Cell Differentiation Synaptic Vesicle Clustering Apoptotic Signaling Pathway Cell-cell Adhesion Positive Regulation Of Odontoblast Differentiation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cranial Skeletal System Development Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Blood Vessel Branching Neuron Projection Extension Embryonic Brain Development Dorsal Root Ganglion Development Establishment Of Blood-retinal Barrier Regulation Of Protein Localization To Cell Surface Positive Regulation Of Determination Of Dorsal Identity Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Myoblast Proliferation Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway	Pattern Recognition Receptor Signaling Pathway Skeletal Muscle Contraction Regulation Of Transcription By RNA Polymerase II Inflammatory Response Immune Response Canonical NF-kappaB Signal Transduction Response To Xenobiotic Stimulus Response To Virus Response To Toxic Substance Anatomical Structure Morphogenesis Response To Acetate Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Interferon-alpha Production Response To Hydroperoxide Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Amino Acid Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Striated Muscle Cell Differentiation Response To Cholecystokinin Cellular Response To Tumor Necrosis Factor Cellular Response To Virus
Pathways		Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Apoptotic cleavage of cell adhesion proteins Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Adherens junctions interactions Binding of TCF/LEF:CTNNB1 to target gene promoters Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Myogenesis Myogenesis Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated RHO GTPases activate IQGAPs Transcriptional Regulation by VENTX InlA-mediated entry of Listeria monocytogenes into host cells RUNX3 regulates WNT signaling Cardiogenesis Germ layer formation at gastrulation Regulation of CDH11 function Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Formation of paraxial mesoderm Formation of axial mesoderm Formation of definitive endoderm Somitogenesis Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Formation of the nephric duct CDH11 homotypic and heterotypic interactions Specification of the neural plate border High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of PD-L1(CD274) transcription	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 AKT phosphorylates targets in the cytosol Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Constitutive Signaling by AKT1 E17K in Cancer NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling PKR-mediated signaling SLC15A4:TASL-dependent IRF5 activation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Modulation of host responses by IFN-stimulated genes
Drugs		Urea	Aminosalicylic acid Mesalazine Acetylcysteine
Diseases		Pilomatricoma; Epithelioma calcificans of Malherbe Gastric cancer Hepatocellular carcinoma Thyroid cancer Colorectal cancer Endometrial Cancer	Cocoon syndrome
GWAS		Bone mineral density (hip) ( 19801982 27311723) Bone mineral density (total hip) ( 29883787) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Femoral neck bone mineral density ( 22504420 29499414) Fractures ( 30158200) Heel bone mineral density ( 28869591 30598549) High myopia ( 31816047) Lumbar spine bone mineral density ( 29499414) Refractive error ( 32231278) Systolic blood pressure ( 30224653)	Liver enzyme levels ( 18940312) Psoriasis ( 28537254) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Type 2 diabetes ( 30054458)
Interacting Genes		205 interacting genes: ACP1 AJAP1 AKT1 AMER1 APC APC2 APP AR ARFGEF1 ARHGAP32 ASH2L AXIN1 AXIN2 BCL3 BCL6 BCL9 BCL9L BOC BRCA1 BTRC CA9 CARM1 CASP3 CASP8 CBL CBY1 CCAR1 CCDC88A CCND1 CDC27 CDC73 CDH1 CDH11 CDH15 CDH16 CDH2 CDH24 CDH3 CDH5 CDH7 CDH8 CDH9 CDK1 CDK2 CDK5R1 CDK6 CDON CEBPA CHD8 CHUK CREBBP CSNK1A1 CSNK1D CSNK2A1 CSNK2B CTNNA1 CTNNA3 CTNNBIP1 CTNND2 DLG5 DSC3 DVL1 DVL3 EGFR ELAVL1 EP300 ERBB2 ERBIN ESM1 ESR1 EZR FBXW2 FER FERMT2 FHIT FHL2 FLT1 FLT3 FOXO1 FOXO4 FSCN1 FUS FYN GLIS2 GNA13 GRIK2 GRIN1 GRIN2D GSK3B H1-2 HIF1A HNF1A HNF4A IGF2BP1 IKBKB IQGAP1 JADE1 KAT2A KAT2B KDR KMT2A KMT2D LATS2 LEF1 LEO1 MAGI1 MAGI2 MAP3K2 MAPK8 MAPK9 MEG3 MEN1 MET MITF MUC1 NAA10 NCOA2 NDRG1 NEK2 NEURL2 NF2 NFKB1 NHERF1 NOTCH1 NR5A1 NR5A2 PECAM1 PFKFB3 PICK1 PIK3R1 PIN1 PITX2 PKD1 PKM PKP2 PLK1 PPM1A PRKCG PSEN1 PSEN2 PTGS2 PTPN1 PTPN13 PTPN14 PTPN6 PTPRF PTPRJ PTPRK PTPRM PTPRU PTPRZ1 PYGO1 RAPGEF2 RBBP5 RIPK1 RUVBL1 RUVBL2 RXRA SALL1 SEC62 SHCBP1 SLC30A9 SMAD2 SMAD3 SMAD4 SMAD7 SMARCA4 SMARCA5 SMURF1 SOX1 SOX10 SOX17 SP1 SPN SRC STUB1 SYNE2 TAX1BP3 TBL1X TCF3 TCF4 TCF7L1 TCF7L2 TFAP2A TGFBR1 TGFBR2 TLE1 TRIM26 TRIM33 TRIM55 TRIM63 TRIP10 TRRAP TSC1 UBC UBE2B UBE2D1 UBE2R2 UBE3A UHRF2 USP10 USP13 USP9X ZFYVE9 ZIC3	85 interacting genes: AKT1 AKT2 AMBRA1 ATM ATR BCL10 BCL3 BTRC CASP8 CDC37 CHEK1 CREBBP CSF2RA CSNK2A1 CTNNB1 CUEDC2 CUL1 DCUN1D5 E2F4 EIF2AK2 ELP1 ERBIN ESR1 FKBP5 FOXO3 H3-4 H3C1 H3C14 HECTD3 HSP90AA1 HSP90AB1 HTT IKBKB IKBKE IKBKG IRS1 MAP3K1 MAP3K11 MAP3K14 MAP3K4 MAP3K7 MAP3K8 MYC NCOA3 NCOR1 NCOR2 NFKB1 NFKB2 NFKBIA NFKBIB NLRP4 NOTCH3 NR2C2 PAX8 PEBP1 PIAS1 PRKCB PRKCI PRKCQ PRKDC PTPN11 RELA RICTOR RIPK2 RPL27 SAMHD1 SRC SRPK1 SRPK2 STAP2 TANK TGFBR1 TNFAIP3 TNFRSF1A TP53 TRAF2 TRAF3IP2 TRAF4 TRIM27 TRPC4AP TTC3 UBC UBE2E3 UBE2I UBE2N
Entrez ID		1499	1147
HPRD ID		00286	02811
Ensembl ID		ENSG00000168036	ENSG00000213341
Uniprot IDs		B4DGU4 P35222	O15111
PDB IDs		1G3J 1JDH 1JPW 1LUJ 1P22 1QZ7 1T08 1TH1 2G57 2GL7 2Z6H 3DIW 3FQN 3FQR 3SL9 3SLA 3TX7 4DJS 6M90 6M91 6M92 6M93 6M94 6O9B 6O9C 6WLX 6WNX 7AFW 7AR4 7UWI 7UWO 7ZRB 8EI9 8EIA 8EIB 8EIC 8RU3 8RU4 8VME 8VMF 8Y0G 8Y0P 8Y14 8Z0U 8Z10 8Z5J 8Z61	3BRT 5EBZ 5TQW 5TQX 5TQY
Enriched GO Terms of Interacting Partners?		Beta-catenin Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Population Proliferation Wnt Signaling Pathway Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Developmental Process Positive Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Positive Regulation Of Signaling Positive Regulation Of Biosynthetic Process Positive Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Intracellular Signal Transduction Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Programmed Cell Death Cellular Developmental Process Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process Anatomical Structure Morphogenesis Nucleoplasm Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway	Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Cytosol Nucleoplasm Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Signaling Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Communication Ubiquitin Protein Ligase Binding Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Non-canonical NF-kappaB Signal Transduction Regulation Of Primary Metabolic Process Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity Regulation Of Apoptotic Process Protein Modification Process Protein Serine Kinase Activity Immune System Process Regulation Of Programmed Cell Death Macromolecule Metabolic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Immune System Process Regulation Of Immune Response Nucleus Transferase Activity Protein Metabolic Process Kinase Activity Regulation Of Innate Immune Response Intracellular Signaling Cassette Cytoplasm Negative Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Stress Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process
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