CTNNB1 and PTGS2

Number of citations of the paper that reports this interaction (PMID 22544606)
5

Data Source:
BioGRID (unspecified method, affinity chromatography technology)

		CTNNB1	PTGS2
Gene Name		catenin (cadherin-associated protein), beta 1, 88kDa	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
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Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Transcription Factor Complex Nuclear Euchromatin Cytoplasm Centrosome Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Cell-cell Adherens Junction Fascia Adherens Tight Junction Focal Adhesion Cell Cortex Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Lamellipodium Cell Junction Beta-catenin Destruction Complex Microvillus Membrane Protein-DNA Complex Scrib-APC-beta-catenin Complex Dendritic Shaft Apical Part Of Cell Synapse Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Beta-catenin-TCF7L2 Complex Cell Periphery	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Caveola Neuron Projection Protein Complex
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Signal Transducer Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Enzyme Binding Kinase Binding Protein Phosphatase Binding Estrogen Receptor Binding Protein Complex Binding Ionotropic Glutamate Receptor Binding Nuclear Hormone Receptor Binding Transcription Regulatory Region DNA Binding Ion Channel Binding Alpha-catenin Binding Cadherin Binding SMAD Binding Androgen Receptor Binding Nitric-oxide Synthase Binding I-SMAD Binding R-SMAD Binding Repressing Transcription Factor Binding Euchromatin Binding	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Lipid Binding Enzyme Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding Arachidonate 15-lipoxygenase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Axis Specification Patterning Of Blood Vessels Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Cell Fate Specification Endodermal Cell Fate Commitment Neuron Migration Epithelial To Mesenchymal Transition Neural Plate Development Liver Development Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Lens Morphogenesis In Camera-type Eye Regulation Of Secondary Heart Field Cardioblast Proliferation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Transcription, DNA-templated Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Adhesion Cell-matrix Adhesion Ectoderm Development Glial Cell Fate Determination Midgut Development Negative Regulation Of Cell Proliferation Anterior/posterior Axis Specification Dorsal/ventral Axis Specification Proximal/distal Pattern Formation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Schwann Cell Proliferation Wnt Signaling Pathway Single Organismal Cell-cell Adhesion Stem Cell Maintenance Layer Formation In Cerebral Cortex Central Nervous System Vasculogenesis Osteoclast Differentiation Androgen Receptor Signaling Pathway Male Genitalia Development Regulation Of Centriole-centriole Cohesion Pancreas Development Hair Follicle Morphogenesis Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Type I Interferon Production T Cell Differentiation In Thymus Negative Regulation Of Protein Sumoylation Response To Cytokine Adherens Junction Assembly Protein Localization To Cell Surface Embryonic Heart Tube Development Genitalia Morphogenesis Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Hair Cell Differentiation Embryonic Skeletal Limb Joint Morphogenesis Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Response To Drug Regulation Of Cell Fate Specification Muscle Cell Differentiation Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Innate Immune Response Myoblast Differentiation Bone Resorption Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Mitotic Cell Cycle, Embryonic Response To Cadmium Ion Regulation Of Fibroblast Proliferation Cell Maturation Synaptic Vesicle Transport Thymus Development Oocyte Development Embryonic Foregut Morphogenesis Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Oligodendrocyte Differentiation Synapse Organization Smooth Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Protein Heterooligomerization Positive Regulation Of Histone H3-K4 Methylation Oviduct Development Canonical Wnt Signaling Pathway Trachea Formation Epithelial Tube Branching Involved In Lung Morphogenesis Lung Cell Differentiation Lung-associated Mesenchyme Development Lung Induction Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Hair Follicle Placode Formation Mesenchymal Cell Proliferation Involved In Lung Development Endothelial Tube Morphogenesis Fungiform Papilla Formation Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Sympathetic Ganglion Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Mechanical Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Indole-3-methanol Renal Vesicle Formation Renal Inner Medulla Development Renal Outer Medulla Development Nephron Tubule Formation Regulation Of Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Calcium Ion Import Negative Regulation Of Neuron Death Cellular Response To Insulin-like Growth Factor Stimulus Regulation Of Protein Localization To Cell Surface Positive Regulation Of Determination Of Dorsal Identity Positive Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Apoptotic Signaling Pathway	Prostaglandin Biosynthetic Process Angiogenesis Prostaglandin Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Nicotinamide Metabolic Process Movement Of Cell Or Subcellular Component Inflammatory Response Response To Oxidative Stress Embryo Implantation Learning Memory Regulation Of Blood Pressure Negative Regulation Of Cell Proliferation Response To Fructose Response To Manganese Ion Response To Lithium Ion Positive Regulation Vascular Endothelial Growth Factor Production Sensory Perception Of Pain Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Lipoxygenase Pathway NAD Metabolic Process Bone Mineralization Ovulation Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation Positive Regulation Of Synaptic Plasticity Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Estradiol Response To Lipopolysaccharide Response To Vitamin D Response To Tumor Necrosis Factor Cellular Response To UV Maintenance Of Blood-brain Barrier Positive Regulation Of NF-kappaB Import Into Nucleus Response To Drug Hair Cycle Positive Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Vasoconstriction Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Decidualization Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Inflammatory Response Brown Fat Cell Differentiation Response To Glucocorticoid Negative Regulation Of Calcium Ion Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Oxidation-reduction Process Response To Fatty Acid Cellular Response To Mechanical Stimulus Cellular Response To ATP Cellular Response To Hypoxia Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Platelet-derived Growth Factor Production
Pathways		APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt binding of TCF/LEF:CTNNB1 to target gene promoters deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation S33 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN Innate Immune System truncations of AMER1 destabilize the destruction complex CDO in myogenesis misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Cytosolic sensors of pathogen-associated DNA formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes beta-catenin independent WNT signaling deletions in the AMER1 gene destabilize the destruction complex Ca2+ pathway Myogenesis AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Metabolism of lipids and lipoproteins Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Arachidonic acid metabolism Defective AMN causes hereditary megaloblastic anemia 1 Nicotinamide salvaging Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Synthesis of 15-eicosatetraenoic acid derivatives Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Defective TCN2 causes hereditary megaloblastic anemia Nicotinate metabolism Defects in vitamin and cofactor metabolism
Drugs		Urea	gamma-Homolinolenic acid Icosapent Aminosalicylic Acid Mesalazine Acetaminophen Indomethacin Nabumetone Ketorolac Tenoxicam Lenalidomide Celecoxib Tolmetin Rofecoxib Piroxicam Fenoprofen Valdecoxib Diclofenac Sulindac Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicyclic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Thalidomide Ibuprofen Lumiracoxib Magnesium salicylate Salicylate-sodium Salsalate Trisalicylate-choline Ginseng Antrafenine Antipyrine Tiaprofenic acid Etoricoxib Flufenamic Acid Resveratrol Heme 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole Prostaglandin G2 Niflumic Acid Nimesulide Lornoxicam Nepafenac Pomalidomide
Diseases
GWAS		Bone mineral density ( 22504420) Bone mineral density (hip) ( 19801982)	Knee osteoarthritis ( 18471798)
Protein-Protein Interactions		172 interactors: ACP1 AJAP1 AKT1 AMER1 APC APC2 APP AR ARHGAP32 ASH2L AXIN1 AXIN2 BCL3 BCL9 BCL9L BOC BRCA1 BTRC CA9 CARM1 CASP3 CASP8 CBL CBY1 CCND1 CDC27 CDC73 CDH1 CDH11 CDH15 CDH16 CDH2 CDH24 CDH3 CDH5 CDH7 CDH8 CDH9 CDK2 CDK5R1 CDK6 CDON CEBPA CHD8 CHUK CREBBP CSNK1A1 CSNK1D CSNK2A1 CSNK2B CTNNA1 CTNNA3 CTNNBIP1 CTNND2 DLG5 DSC3 DVL1 DVL3 EGFR ELAVL1 EP300 ERBB2 ERBB2IP ESR1 EZR FER FHIT FHL2 FLT1 FOXO1 FOXO4 FSCN1 FUS FYN GLIS2 GNA13 GRIK2 GRIN1 GRIN2D GSK3B HDAC6 HIF1A HIST1H1C HNF1A IGF2BP1 IKBKB IQGAP1 JADE1 KAT2A KAT2B KDR KMT2A KMT2D LATS2 LEF1 LEO1 MAGI1 MAGI2 MAPK8 MAPK9 MEN1 MET MITF MUC1 NCOA2 NDRG1 NEK2 NEURL2 NF2 NFKB1 NOTCH1 NR5A1 PECAM1 PICK1 PIK3R1 PIN1 PITX2 PKD1 PKP2 PLK1 PPM1A PSEN1 PSEN2 PTGS2 PTPN1 PTPN13 PTPN14 PTPN6 PTPRF PTPRJ PTPRK PTPRM PTPRU PTPRZ1 PYGO1 RAPGEF2 RBBP5 RBX1 RUVBL1 RUVBL2 RXRA SALL1 SIAH1 SKP1 SLC9A3R1 SMAD2 SMAD3 SMAD4 SMAD7 SMARCA4 SMARCA5 SOX1 SOX17 SPN SRC TAX1BP3 TBL1X TCF3 TCF4 TCF7L1 TCF7L2 TFAP2A TGFBR1 TGFBR2 TLE1 TRIP10 TRRAP UBE2B UBE2D1 UHRF2 USP9X ZFYVE9	11 interactors: ABHD16A CASK CAV1 CELF2 COPS5 COPS7A CTNNB1 ELAVL1 NUCB1 PTGIS TP53
Entrez ID		1499	5743
HPRD ID		00286	02599
Ensembl ID		ENSG00000168036	ENSG00000073756
Uniprot IDs		P35222	P35354
PDB IDs		1G3J 1JDH 1JPW 1LUJ 1P22 1QZ7 1T08 1TH1 2G57 2GL7 2Z6H 3DIW 3FQN 3FQR 3SL9 3SLA 3TX7 4DJS	1V0X
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Gene Expression Signaling Cell Communication Signal Transduction Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Development Multicellular Organismal Development Regulation Of Metabolic Process Response To Stimulus Developmental Process Negative Regulation Of Signaling Wnt Signaling Pathway Anatomical Structure Morphogenesis Cell Differentiation Negative Regulation Of Signal Transduction System Development Regulation Of Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Organ Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Tissue Development Negative Regulation Of Cellular Metabolic Process Cell Development Regulation Of Wnt Signaling Pathway Regulation Of Cell Differentiation Regulation Of Cellular Process Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Epithelium Development Regulation Of RNA Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Reactive Oxygen Species Metabolic Process Cullin Deneddylation Protein Deneddylation Cellular Response To Oxygen Levels Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Calcium Ion Import Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Calcium Ion Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Ischemia Positive Regulation Of Cell Death Negative Regulation Of Cell Proliferation Regulation Of Neuroblast Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Epithelial Cell Proliferation Response To Hypoxia Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Lactation Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Differentiation In Thymus Regulation Of Reactive Oxygen Species Biosynthetic Process Apoptotic Signaling Pathway Positive Regulation Of Histone Modification Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ion Transmembrane Transport Cell Death Protein Oligomerization Death Canonical Wnt Signaling Pathway Positive Regulation Of Calcium Ion Transport Vasculogenesis Response To Abiotic Stimulus Regulation Of Fibroblast Proliferation Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Macromitophagy Negative Regulation Of Mitotic Cell Cycle, Embryonic
Tagcloud ?		acc acquires adrenal adrenocortical altering came centripetal compr cortex detail examining exome gland igf2 landscape medulla mutational opening perspectives physiol played prognostication progress steroidogenic subcapsular summarizes tracing zonation zones	20b 34a 7e actively ccnd ccne1 compromised dysregulated enterotoxin exacerbation foxo3 infiltrating let lungs mir mirna orchestrating participating pertaining poisoning runx1 saw seb silico smad3 staphyloccocal stringent tbx21 tgfb
Tagcloud (Difference) ?		acc acquires adrenal adrenocortical altering came centripetal compr cortex detail examining exome gland igf2 landscape medulla mutational opening perspectives physiol played prognostication progress steroidogenic subcapsular summarizes tracing zonation zones	20b 34a 7e actively ccnd ccne1 compromised dysregulated enterotoxin exacerbation foxo3 infiltrating let lungs mir mirna orchestrating participating pertaining poisoning runx1 saw seb silico smad3 staphyloccocal stringent tbx21 tgfb
Tagcloud (Intersection) ?