ADGRB3 and ELMO1

Number of citations: 39 (PubMedID 21930703)
Data Source: BioGRID (two hybrid)

		ADGRB3	ELMO1
Name		adhesion G protein-coupled receptor B3	engulfment and cell motility 1
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Synaptic Cleft Postsynapse Postsynaptic Density Membrane Cerebellar Climbing Fiber To Purkinje Cell Synapse	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex Postsynapse Glutamatergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity GTPase Activator Activity Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Myoblast Fusion Neuron Remodeling Negative Regulation Of Angiogenesis Cell Differentiation Regulation Of Dendrite Morphogenesis Positive Regulation Of Synapse Assembly Motor Learning Regulation Of Synapse Maturation Maintenance Of Synapse Structure Regulation Of Synapse Pruning	Phagocytosis Phagocytosis, Engulfment Apoptotic Process Actin Filament Organization Rac Protein Signal Transduction Actin Filament-based Process Actin Cytoskeleton Organization Cell Motility Regulation Of Postsynapse Assembly
Pathways		None	Nef and signal transduction Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis
GWAS		Adiponectin levels ( 33562295 ) Body mass index and systolic blood pressure (bivariate analysis) ( 33539483 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) General risk tolerance (MTAG) ( 30643258 ) Negative urgency ( 30718321 ) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552 )	Alzheimer's disease (cognitive decline) ( 23535033 ) Anticoagulant levels ( 22216198 ) Autoimmune thyroid disease ( 32581359 ) Autoimmune traits (pleiotropy) ( 30572963 ) Body fat mass ( 28552196 ) Breast size ( 22747683 ) Celiac disease ( 25920553 30572963 22057235 20190752 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Celiac disease or Rheumatoid arthritis ( 21383967 ) Cerebrospinal fluid AB1-42 levels ( 28247064 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Height ( 31562340 ) Inflammatory skin disease ( 25574825 ) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mean platelet volume ( 32888494 27863252 ) Medication use (thyroid preparations) ( 31015401 ) Multiple sclerosis ( 31604244 24076602 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 32888494 ) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243 ) Platelet count ( 32888494 ) Platelet distribution width ( 27863252 32888494 ) PR interval ( 32439900 ) Primary biliary cirrhosis ( 22961000 ) Psoriasis ( 25574825 23143594 ) Psoriasis vulgaris ( 26626624 ) QT interval ( 20031603 ) Response to treatment for acute lymphoblastic leukemia ( 19176441 ) Rheumatoid arthritis ( 23143596 ) Sum eosinophil basophil counts ( 27863252 ) Systemic sclerosis ( 30572963 ) Trunk fat mass ( 28552196 ) Type 2 diabetes nephropathy ( 17653210 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		9 interacting genes: C1QL3 DSCR9 ELMO1 GPATCH11 GPR37L1 MUC1 SLC7A1 SNTA1 TLCD4	11 interacting genes: ADGRB1 ADGRB3 APBB1 CEBPA DOCK1 DOCK2 FGD1 HCK RHOG TRIM54 ZNF398
Entrez ID		577	9844
HPRD ID		04064	12102
Ensembl ID		ENSG00000135298	ENSG00000155849
Uniprot IDs		O60242	A4D1X5 Q92556
PDB IDs		4DLO	2RQR 2VSZ 3A98 6JPP 6TGB 6TGC 7DPA 7Y4A 8JHK 8XM7 8ZJ2 8ZJI 8ZJJ 8ZJK 8ZJL 8ZJM
GO Terms Enriched among Interactors		None	Myoblast Fusion Cell-cell Fusion Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Regulation Of Synapse Assembly Signal Transduction Regulation Of Cell Junction Assembly Regulation Of Cellular Component Organization Regulation Of Synapse Organization Phagocytosis Regulation Of Cell Shape Regulation Of Anatomical Structure Morphogenesis Endocytosis Phagocytosis, Engulfment Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Cellular Component Organization Regulation Of Postsynapse Assembly Postsynapse Membrane Invagination Regulation Of Cell Morphogenesis Import Into Cell Developmental Process GTPase Activator Activity Small GTPase-mediated Signal Transduction Cell Projection Positive Regulation Of Synapse Assembly RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Small GTPase Binding Actin Cytoskeleton Organization Cytoskeleton Response To Vitamin B2 C/EBP Complex Plasma Membrane Actin Filament-based Process Intracellular Signaling Cassette Cell Migration Regulation Of Developmental Process CHOP-C/EBP Complex Integrin-mediated Signaling Pathway Membrane Raft Polarization Regulation Of Phagocytosis Myeloid Dendritic Cell Activation Involved In Immune Response Leukocyte Migration Involved In Immune Response Positive Regulation Of Cell Junction Assembly Focal Adhesion White Fat Cell Proliferation Respiratory Burst After Phagocytosis Cell Recognition Regulation Of GTPase Activity Intracellular Signal Transduction