SRSF4 and FUS

Number of citations of the paper that reports this interaction (PMID 12581738)
24

Data Source:
HPRD (in vivo)

		SRSF4	FUS
Gene Name		serine/arginine-rich splicing factor 4	FUS RNA binding protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Nucleotide Binding Poly(A) RNA Binding	Nucleotide Binding DNA Binding RNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Hematopoietic Progenitor Cell Differentiation Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Processing MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing Negative Regulation Of MRNA Splicing, Via Spliceosome	MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: DYRK1A FUS GEMIN2 HAP1 HTATSF1 PNN PPARGC1A PRPF38A RNPS1 SART1 SCAF11 SMURF1 SMURF2 SREK1 SRPK1 SRRM2 SRSF1 SRSF10 SRSF2 SRSF6 TICAM1 TRA2B ZDHHC17	39 interactors: ATXN1L CTNNB1 ESRRA EWSR1 GRIN1 GRIN2D IL7R ILF3 KHDRBS3 MAX MDH1 NKD2 NUPR1 PA2G4 POLR2A PRMT1 PSMB7 PTBP1 RBMX RELA RXRA SAFB2 SF1 SFPQ SPI1 SRRM1 SRSF10 SRSF2 SRSF4 SRSF9 SUV39H1 TAF15 TARDBP TDRD3 THRA TNIP1 WBP4 YBX1 ZMYM2
Entrez ID		6429	2521
HPRD ID		09052	00660
Ensembl ID		ENSG00000116350	ENSG00000089280
Uniprot IDs		Q08170	P35637 Q13344 Q6IBQ5
PDB IDs			2LA6 2LCW 4FDD 4FQ3
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Gene Expression Regulation Of MRNA Processing Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nuclear Export Nitrogen Compound Metabolic Process Spliceosomal Complex Assembly MRNA Export From Nucleus RNA Export From Nucleus Regulation Of Alternative MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex Assembly Termination Of RNA Polymerase II Transcription MRNA Transport Cellular Metabolic Process Nucleocytoplasmic Transport Nuclear Transport RNA Transport RNA Localization Ribonucleoprotein Complex Biogenesis Negative Regulation Of MRNA Splicing, Via Spliceosome DNA-templated Transcription, Termination Negative Regulation Of RNA Splicing MRNA 3'-end Processing Regulation Of RNA Metabolic Process RNA 3'-end Processing Regulation Of Nitrogen Compound Metabolic Process Spliceosomal SnRNP Assembly MRNA Splice Site Selection Ubiquitin-dependent SMAD Protein Catabolic Process Cellular Macromolecular Complex Assembly Regulation Of Gene Expression Cytoplasmic Transport Metabolic Process MRNA Cis Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Intracellular Transport Regulation Of Metabolic Process	Gene Expression Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process RNA Splicing Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process MRNA Processing Transcription From RNA Polymerase II Promoter Biosynthetic Process MRNA Metabolic Process Regulation Of Transcription, DNA-templated RNA Processing Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Splicing Positive Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Splicing Regulation Of Cellular Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Transcription, DNA-templated MRNA Export From Nucleus RNA Export From Nucleus Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter
Tagcloud ?		abundant altering changed clk decay deep detained detention dis dramatic evolutionarily half hour intron introns lives mdm4 nmd nonsense polyadenylated pools shift splicing subject thousands transcript triggered undergoes widespread	antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Difference) ?		abundant altering changed clk decay deep detained detention dis dramatic evolutionarily half hour intron introns lives mdm4 nmd nonsense polyadenylated pools shift splicing subject thousands transcript triggered undergoes widespread	antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Intersection) ?