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KASH5 and MMP14
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
KASH5
MMP14
Description
KASH domain containing 5
matrix metallopeptidase 14
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Lateral Element
Nucleus
Nuclear Envelope
Nuclear Outer Membrane
Chromosome
Membrane
Meiotic Nuclear Membrane Microtubule Tethering Complex
Meiotic Spindle Pole
Extracellular Space
Nucleus
Cytoplasm
Golgi Lumen
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Extracellular Matrix
Cytoplasmic Vesicle
Melanosome
Macropinosome
Intermediate Filament Cytoskeleton
Molecular Function
Protein Binding
Identical Protein Binding
Dynein Complex Binding
Endopeptidase Activity
Metalloendopeptidase Activity
Serine-type Endopeptidase Activity
Integrin Binding
Protein Binding
Peptidase Activity
Metallopeptidase Activity
Zinc Ion Binding
Hydrolase Activity
Metal Ion Binding
Metalloaminopeptidase Activity
Biological Process
Double-strand Break Repair Via Homologous Recombination
Actin Filament Organization
Homologous Chromosome Pairing At Meiosis
Spermatogenesis
Telomere Localization
Meiotic Telomere Clustering
Oogenesis
Spindle Assembly
Meiotic Cell Cycle
Spindle Localization
Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation
Skeletal System Development
Ossification
Angiogenesis
Ovarian Follicle Development
Response To Hypoxia
Endothelial Cell Proliferation
Endochondral Ossification
Proteolysis
Response To Oxidative Stress
Male Gonad Development
Response To Mechanical Stimulus
Anatomical Structure Morphogenesis
Response To Hormone
Positive Regulation Of Myotube Differentiation
Positive Regulation Of Protein Processing
Cell Migration
Protein Processing
Extracellular Matrix Disassembly
Protein Catabolic Process
Extracellular Matrix Organization
Positive Regulation Of Cell Growth
Lung Development
Positive Regulation Of Cell Migration
Collagen Catabolic Process
Zymogen Activation
Endodermal Cell Differentiation
Chondrocyte Proliferation
Astrocyte Cell Migration
Response To Estrogen
Positive Regulation Of B Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Embryonic Cranial Skeleton Morphogenesis
Branching Morphogenesis Of An Epithelial Tube
Tissue Remodeling
Cell Motility
Negative Regulation Of Focal Adhesion Assembly
Head Development
Bone Development
Cellular Response To Genistein
Craniofacial Suture Morphogenesis
GDF15-GFRAL Signaling Pathway
Negative Regulation Of GDF15-GFRAL Signaling Pathway
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Macrophage Migration
Response To Odorant
Pathways
Collagen degradation
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
TGFBR3 PTM regulation
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Marimastat
Diseases
GWAS
Appendicular lean mass (
33097823
)
Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment (
32472697
)
Diastolic blood pressure (
30224653
)
Dupuytren's disease (
28886342
)
Heel bone mineral density (
28869591
30598549
)
Prostate cancer (
29892016
)
Waist-to-hip ratio adjusted for BMI (additive genetic model) (
30778226
)
Interacting Genes
112 interacting genes:
ABHD1
ADIPOQ
ANKRD46
ATF7
BAG5
BCL2L2
BET1
C14orf180
CCDC120
CCDC87
CDC73
CDKL3
CIB3
CLDN8
CMTM5
CRABP2
CTXN3
CWF19L2
CXCL16
CXCL9
CYBC1
DERL1
DNAJC30
EFNA5
EMD
FAM161A
FAM241B
FAM50B
FAM90A1
FATE1
FIS1
FRA10AC1
FTCD
FXYD3
GABARAPL2
GALNT2
GIMAP5
GOSR2
GPATCH4
GPR25
HMOX1
ITGAM
ITM2B
JAGN1
KDM1A
LARP1
LAT
LENG1
LHFPL5
LMNA
LRCH4
MALL
MARCHF2
MMP14
MOSPD3
MS4A1
MTX2
NRIP3
NSG1
NTAQ1
OLFM4
PDGFRA
PGAP2
PGRMC1
PIGU
PLP2
PLPP6
PPP1R18
RIPPLY2
RNF146
RSPH14
RSRC2
RTP2
SENP2
SERP2
SGTA
SHMT2
SLC30A2
SLC35B4
SLC41A1
SLC41A2
SLC5A4
SLC61A1
SLN
SMCO4
SNAP47
STBD1
STX12
STX5
TCF25
TMEM11
TMEM147
TMEM14C
TMEM19
TMEM41A
TMEM86A
TMPRSS4
TNF
TRAF3IP3
TRARG1
TSHZ3
TTC23
UPK1B
UPK2
VAMP1
VAMP2
VAMP4
VMA12
VTI1B
ZC2HC1C
ZFPL1
ZNF250
44 interacting genes:
ACAN
ACE2
ADI1
AQP6
BCAR1
C1QBP
CAV1
CCL7
CCN2
CCN5
CLDN1
CORO1C
CXCL8
EBP
ELOVL4
F11R
F12
FHL3
FURIN
HSD17B13
ITGAV
KASH5
KISS1
LRP1
LUM
MMP13
MMP2
MMP3
MSMO1
PLLP
RRAD
SDC1
SLPI
SPOCK1
SPOCK3
STOM
TGM2
TIMP2
TIMP3
TIMP4
TMEM31
TNF
TNFRSF21
ZUP1
Entrez ID
147872
4323
HPRD ID
08134
02856
Ensembl ID
ENSG00000161609
ENSG00000157227
Uniprot IDs
Q8N6L0
P50281
PDB IDs
6R2I
6WMF
1BQQ
1BUV
2MQS
3C7X
3MA2
3X23
4P3C
4P3D
4QXU
5H0U
6CLZ
6CM1
Enriched GO Terms of Interacting Partners
?
Membrane
SNARE Complex
SNAP Receptor Activity
Protein Binding
Endoplasmic Reticulum Membrane
Vesicle Fusion
Organelle Fusion
Organelle Membrane Fusion
Membrane Fusion
Endoplasmic Reticulum
SNARE Binding
Membrane Organization
Localization Within Membrane
Vesicle Organization
Presynaptic Endosome Membrane
SNARE Complex Assembly
Mitochondrial Outer Membrane
Establishment Of Protein Localization To Membrane
Golgi Membrane
Endosome To Plasma Membrane Protein Transport
Positive Regulation Of Neutrophil Activation
Regulation Of Cellular Localization
Monoatomic Cation Transmembrane Transporter Activity
Vesicle-mediated Transport
Endomembrane System
Establishment Of Protein Localization To Plasma Membrane
Extracellular Matrix
Extracellular Space
Extracellular Region
Metalloendopeptidase Inhibitor Activity
Regulation Of Membrane Protein Ectodomain Proteolysis
Enzyme Inhibitor Activity
Regulation Of Entry Of Bacterium Into Host Cell
Symbiont Entry Into Host Cell
Response To Amyloid-beta
Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Regulation Of Cell Motility
Regulation Of Locomotion
Biological Process Involved In Interaction With Host
Extracellular Matrix Organization
Extracellular Structure Organization
Collagen Catabolic Process
Endopeptidase Activity
Regulation Of Cell Migration
Regulation Of Cell Adhesion
Regulation Of Proteolysis
Regulation Of Transcytosis
Extracellular Matrix Disassembly
Peptidase Inhibitor Activity
Positive Regulation Of Cell Migration
Cell Migration
Positive Regulation Of Cell Motility
Endocytosis
Membrane Raft
Positive Regulation Of Locomotion
Collagen Binding
Collagen Metabolic Process
Regulation Of Viral Process
Leukocyte Migration
Regulation Of Bicellular Tight Junction Assembly
Apoptotic Cell Clearance
Negative Regulation Of Proteolysis
Viral Translation
Viral Life Cycle
Regulation Of Protein Catabolic Process
Serine-type Endopeptidase Activity
Regulation Of Multicellular Organismal Process
Humoral Immune Response
Heparin Binding
Cell Motility
Regulation Of Cell Junction Assembly
Virus Receptor Activity
Extracellular Matrix Binding
Response To Cytokine
Response To Peptide
Receptor-mediated Endocytosis
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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