KASH5 and VMA12

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KASH5	VMA12
Description		KASH domain containing 5	vacuolar ATPase assembly factor VMA12
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Lateral Element Nucleus Nuclear Envelope Nuclear Outer Membrane Chromosome Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Meiotic Spindle Pole	Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane Vacuolar Proton-transporting V-type ATPase Complex COPI-coated Vesicle Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Protein Binding Identical Protein Binding Dynein Complex Binding	Protein Binding Oxysterol Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Actin Filament Organization Homologous Chromosome Pairing At Meiosis Spermatogenesis Telomere Localization Meiotic Telomere Clustering Oogenesis Spindle Assembly Meiotic Cell Cycle Spindle Localization Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation	Intracellular Iron Ion Homeostasis Lysosomal Lumen Acidification Cellular Response To Increased Oxygen Levels Vacuolar Proton-transporting V-type ATPase Complex Assembly Lysosomal Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS
Interacting Genes		112 interacting genes: ABHD1 ADIPOQ ANKRD46 ATF7 BAG5 BCL2L2 BET1 C14orf180 CCDC120 CCDC87 CDC73 CDKL3 CIB3 CLDN8 CMTM5 CRABP2 CTXN3 CWF19L2 CXCL16 CXCL9 CYBC1 DERL1 DNAJC30 EFNA5 EMD FAM161A FAM241B FAM50B FAM90A1 FATE1 FIS1 FRA10AC1 FTCD FXYD3 GABARAPL2 GALNT2 GIMAP5 GOSR2 GPATCH4 GPR25 HMOX1 ITGAM ITM2B JAGN1 KDM1A LARP1 LAT LENG1 LHFPL5 LMNA LRCH4 MALL MARCHF2 MMP14 MOSPD3 MS4A1 MTX2 NRIP3 NSG1 NTAQ1 OLFM4 PDGFRA PGAP2 PGRMC1 PIGU PLP2 PLPP6 PPP1R18 RIPPLY2 RNF146 RSPH14 RSRC2 RTP2 SENP2 SERP2 SGTA SHMT2 SLC30A2 SLC35B4 SLC41A1 SLC41A2 SLC5A4 SLC61A1 SLN SMCO4 SNAP47 STBD1 STX12 STX5 TCF25 TMEM11 TMEM147 TMEM14C TMEM19 TMEM41A TMEM86A TMPRSS4 TNF TRAF3IP3 TRARG1 TSHZ3 TTC23 UPK1B UPK2 VAMP1 VAMP2 VAMP4 VMA12 VTI1B ZC2HC1C ZFPL1 ZNF250	17 interacting genes: AQP6 BIK CCR2 CD300A EBP ELOVL4 ERLIN1 IFNGR2 JAGN1 KASH5 LMNA REEP4 SLC10A4 STX1A STX4 TIMMDC1 TMEM14B
Entrez ID		147872	147007
HPRD ID		08134	12679
Ensembl ID		ENSG00000161609	ENSG00000244045
Uniprot IDs		Q8N6L0	Q8N511
PDB IDs		6R2I 6WMF
Enriched GO Terms of Interacting Partners?		Membrane SNARE Complex SNAP Receptor Activity Protein Binding Endoplasmic Reticulum Membrane Vesicle Fusion Organelle Fusion Organelle Membrane Fusion Membrane Fusion Endoplasmic Reticulum SNARE Binding Membrane Organization Localization Within Membrane Vesicle Organization Presynaptic Endosome Membrane SNARE Complex Assembly Mitochondrial Outer Membrane Establishment Of Protein Localization To Membrane Golgi Membrane Endosome To Plasma Membrane Protein Transport Positive Regulation Of Neutrophil Activation Regulation Of Cellular Localization Monoatomic Cation Transmembrane Transporter Activity Vesicle-mediated Transport Endomembrane System Establishment Of Protein Localization To Plasma Membrane	Membrane Regulation Of Regulated Secretory Pathway Regulation Of Exocytosis Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Glutamate Receptor Signaling Pathway SNARE Complex Assembly Regulation Of Secretion By Cell Nuclear Envelope Organization Regulation Of Secretion Endoplasmic Reticulum Membrane Positive Regulation Of Synaptic Transmission Nitrate Transmembrane Transporter Activity Regulation Of Release Of Cytochrome C From Mitochondria Mitochondrial Membrane Organelle Localization SNARE Complex Regulation Of Insulin Secretion Insulin Secretion Positive Regulation Of Regulated Secretory Pathway Regulation Of Peptide Hormone Secretion SNAP Receptor Activity Myosin Head/neck Binding Exocytosis Sphingomyelin Phosphodiesterase Activator Activity Cholesterol-5,6-oxide Hydrolase Activity Negative Regulation Of Secretion Negative Regulation Of Secretion By Cell Negative Regulation Of Eosinophil Activation Negative Regulation Of Exocytosis Negative Regulation Of Phagocytosis, Engulfment Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Nuclear Envelope PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Type II Interferon Receptor Activity DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina SNARE Binding Vesicle Docking Regulation Of Vesicle-mediated Transport Positive Regulation Of Eosinophil Degranulation Membrane Assembly Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Storage Vacuole C-8 Sterol Isomerase Activity Cholestenol Delta-isomerase Activity
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