KASH5 and SENP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KASH5	SENP2
Description		KASH domain containing 5	SUMO specific peptidase 2
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Lateral Element Nucleus Nuclear Envelope Nuclear Outer Membrane Chromosome Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Meiotic Spindle Pole	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Body PML Body Nuclear Membrane
	Molecular Function	Protein Binding Identical Protein Binding Dynein Complex Binding	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity SUMO-specific Endopeptidase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Actin Filament Organization Homologous Chromosome Pairing At Meiosis Spermatogenesis Telomere Localization Meiotic Telomere Clustering Oogenesis Spindle Assembly Meiotic Cell Cycle Spindle Localization Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation	Proteolysis Heart Development Protein Transport Wnt Signaling Pathway Protein Sumoylation Protein Desumoylation Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Destabilization Regulation Of DNA Endoreduplication Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Regulation Of Macromolecule Metabolic Process Trophoblast Giant Cell Differentiation Labyrinthine Layer Development Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			SUMO is proteolytically processed
Drugs
Diseases
GWAS			Diastolic blood pressure ( 27841878 28135244) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462 31152163) Height ( 28552196) Hip circumference ( 28552196) JT interval ( 29874175) PR interval ( 30046033 32439900) QRS duration ( 30012220) Seborrheic dermatitis ( 29203360) Systolic blood pressure ( 26969751 27841878)
Interacting Genes		112 interacting genes: ABHD1 ADIPOQ ANKRD46 ATF7 BAG5 BCL2L2 BET1 C14orf180 CCDC120 CCDC87 CDC73 CDKL3 CIB3 CLDN8 CMTM5 CRABP2 CTXN3 CWF19L2 CXCL16 CXCL9 CYBC1 DERL1 DNAJC30 EFNA5 EMD FAM161A FAM241B FAM50B FAM90A1 FATE1 FIS1 FRA10AC1 FTCD FXYD3 GABARAPL2 GALNT2 GIMAP5 GOSR2 GPATCH4 GPR25 HMOX1 ITGAM ITM2B JAGN1 KDM1A LARP1 LAT LENG1 LHFPL5 LMNA LRCH4 MALL MARCHF2 MMP14 MOSPD3 MS4A1 MTX2 NRIP3 NSG1 NTAQ1 OLFM4 PDGFRA PGAP2 PGRMC1 PIGU PLP2 PLPP6 PPP1R18 RIPPLY2 RNF146 RSPH14 RSRC2 RTP2 SENP2 SERP2 SGTA SHMT2 SLC30A2 SLC35B4 SLC41A1 SLC41A2 SLC5A4 SLC61A1 SLN SMCO4 SNAP47 STBD1 STX12 STX5 TCF25 TMEM11 TMEM147 TMEM14C TMEM19 TMEM41A TMEM86A TMPRSS4 TNF TRAF3IP3 TRARG1 TSHZ3 TTC23 UPK1B UPK2 VAMP1 VAMP2 VAMP4 VMA12 VTI1B ZC2HC1C ZFPL1 ZNF250	40 interacting genes: ACSF2 AGTRAP APOC2 APOC4 APP AR ARL6IP1 ARMC12 AXIN1 CDCA5 CDK5RAP2 DAXX ERCC6 FUNDC1 FZR1 HCCS IKBKG KASH5 KPNA1 KPNB1 LMNA MYC NACC1 NEDD4L NUP153 OGT PML RANGAP1 RETREG3 RPRM SDR16C5 STK38 SUMO1 SUMO2 SUMO3 SYNE4 TMEM239 TNFRSF10D TPD52 TRIM63
Entrez ID		147872	59343
HPRD ID		08134	07002
Ensembl ID		ENSG00000161609	ENSG00000163904
Uniprot IDs		Q8N6L0	Q9HC62
PDB IDs		6R2I 6WMF	1TGZ 1TH0 2IO0 2IO1 2IO2 2IO3 3ZO5 5AEK
Enriched GO Terms of Interacting Partners?		Membrane SNARE Complex SNAP Receptor Activity Protein Binding Endoplasmic Reticulum Membrane Vesicle Fusion Organelle Fusion Organelle Membrane Fusion Membrane Fusion Endoplasmic Reticulum SNARE Binding Membrane Organization Localization Within Membrane Vesicle Organization Presynaptic Endosome Membrane SNARE Complex Assembly Mitochondrial Outer Membrane Establishment Of Protein Localization To Membrane Golgi Membrane Endosome To Plasma Membrane Protein Transport Positive Regulation Of Neutrophil Activation Regulation Of Cellular Localization Monoatomic Cation Transmembrane Transporter Activity Vesicle-mediated Transport Endomembrane System Establishment Of Protein Localization To Plasma Membrane	Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Sumoylation Positive Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Pore Regulation Of Proteolysis Nuclear Membrane Protein Modification By Small Protein Conjugation Protein Localization To Nucleus PML Body Protein Tag Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Protein Import Into Nucleus Nuclear Envelope Import Into Nucleus Very-low-density Lipoprotein Particle Chromatin Organization Post-translational Protein Modification Endoplasmic Reticulum Tubular Network Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Nuclear Localization Sequence Binding High-density Lipoprotein Particle Regulation Of Protein Catabolic Process Ubiquitin-like Protein Ligase Binding Positive Regulation Of Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intermediate-density Lipoprotein Particle Nucleus Organization Protein Binding DNA Damage Response Positive Regulation Of Protein Metabolic Process Protein Localization To Organelle Regulation Of Proteasomal Protein Catabolic Process PML Body Organization Chromatin Remodeling Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Apoptotic Process Regulation Of Protein Localization Molecular Condensate Scaffold Activity Programmed Cell Death Protein Modification Process NLS-dependent Protein Nuclear Import Complex Meiotic Nuclear Membrane Microtubule Tethering Complex
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