FAM83D and DYNC1I1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)

		FAM83D	DYNC1I1
Description		family with sequence similarity 83 member D	dynein cytoplasmic 1 intermediate chain 1
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Cytoskeleton Intercellular Bridge Mitotic Spindle Mitotic Spindle Pole	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Dynein Complex Vesicle Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding	Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding Microtubule Binding Spectrin Binding Dynein Light Chain Binding Dynein Heavy Chain Binding
	Biological Process	Epithelial To Mesenchymal Transition Signal Transduction Cell Population Proliferation Cell Migration Regulation Of TOR Signaling Regulation Of Protein Catabolic Process Cell Division Metaphase Chromosome Alignment Regulation Of ERK1 And ERK2 Cascade Protein Localization To Mitotic Spindle Positive Regulation Of Cell Cycle G1/S Phase Transition	Microtubule-based Movement Transport Along Microtubule Vesicle Transport Along Microtubule
Pathways		Signaling by EGFR	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis ( 28714907) Huntington's disease progression ( 28642124)	Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Immune reponse to smallpox (secreted IL-10) ( 22610502) Knee osteoarthritis ( 27696742) Multisite chronic pain ( 31194737 33830993) Obesity-related traits ( 23251661) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: CSNK1E DYNC1I1 GADD45A GSK3B PRMT1	35 interacting genes: ACADM ANXA7 BICD1 CADM4 CDKN1A DCTN1 DNM2 DYNLL1 DYNLL2 DYNLRB1 DYNLT1 DYNLT3 EMILIN1 FAM110A FAM83D FBP1 GRB7 GSK3B KAT7 LCOR MCC NAGK NUDT21 PIN1 RAP1GAP RBPMS RCC1 RUNDC3B SMN1 STAU1 TAOK1 TK1 TRIM58 WDCP YTHDF1
Entrez ID		81610	1780
HPRD ID		12744	04798
Ensembl ID		ENSG00000101447	ENSG00000158560
Uniprot IDs		Q9H4H8	A4D1I7 O14576 Q8N542
PDB IDs		5E0L 5E0M
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Localization To Centrosome Regulation Of Protein Localization To Centrosome Positive Regulation Of P38MAPK Cascade Viral Protein Processing Regulation Of P38MAPK Cascade Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Canonical Wnt Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Circadian Rhythm DNA Repair Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Negative Regulation Of TOR Signaling Superior Temporal Gyrus Development TOR Signaling Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome GATOR1 Complex Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Cytoplasm Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Circadian Rhythm Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of JNK Cascade Negative Regulation Of Protein Metabolic Process Perinuclear Region Of Cytoplasm Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of TOR Signaling Negative Regulation Of TORC2 Signaling Positive Regulation Of Translation Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of Glycogen (starch) Synthase Activity Viral Process Protein-arginine Omega-N Monomethyltransferase Activity N-methyltransferase Activity Histone H4R3 Methyltransferase Activity Positive Regulation Of Hemoglobin Biosynthetic Process Peptidyl-arginine Methylation Regulation Of Centriole-centriole Cohesion Positive Regulation Of Proteolysis DNA Metabolic Process Regulation Of Signal Transduction	Dynein Intermediate Chain Binding Dynein Complex Cytoplasmic Dynein Complex Microtubule-based Process Microtubule Microtubule Associated Complex Tau Protein Binding Cytoplasmic Stress Granule Microtubule-based Movement Centrosome Regulation Of Microtubule-based Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Intracellular Transport Stress Granule Assembly Identical Protein Binding Microtubule Cytoskeleton Organization Positive Regulation Of Protein Localization To Centrosome Cellular Component Assembly Regulation Of Long-term Synaptic Potentiation Cytoplasm Secretory Vesicle Regulation Of DNA Replication Ciliary Tip Regulation Of Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Response To Phorbol 13-acetate 12-myristate Intracellular MRNA Localization Regulation Of Protein Localization To Centrosome Positive Regulation Of Intracellular Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway MRNA Binding Microtubule Anchoring At Microtubule Organizing Center Microtubule Cytoskeleton Viral Process Mitotic Cell Cycle Phase Transition Dynactin Binding Replicative Senescence Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway MRNA Export From Nucleus Membraneless Organelle Assembly Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cellular Component Organization Negative Regulation Of Phosphate Metabolic Process Cell Cycle Phase Transition Scaffold Protein Binding Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Cytoskeleton Protein Kinase Binding Transport Along Microtubule Organelle Localization
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