ZMYND8 and ATRX

Number of citations: 113 (PubMedID 34780483)
Data Source: BioGRID (two hybrid, proximity labelling technology)

		ZMYND8	ATRX
Name		zinc finger MYND-type containing 8	ATRX chromatin remodeler
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Dendritic Spine Dendritic Shaft Site Of DNA Damage	Nuclear Chromosome Condensed Chromosome, Centromeric Region Chromosome, Telomeric Region Heterochromatin Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Nuclear Body PML Body Chromosome, Subtelomeric Region
	Molecular Function	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding Histone H3K14ac Reader Activity Histone H3K4me1 Reader Activity DNA-binding Transcription Factor Binding	Nucleotide Binding DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding DNA Translocase Activity Hydrolase Activity ATP Hydrolysis Activity Chromatin DNA Binding Histone Binding Metal Ion Binding Histone H3K9me2/3 Reader Activity Chromo Shadow Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Chromatin Organization Regulation Of DNA-templated Transcription Nervous System Development Negative Regulation Of Cell Migration Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Filopodium Assembly Positive Regulation Of Dendritic Spine Development Protein Localization To Chromatin Modulation Of Excitatory Postsynaptic Potential Regulation Of Postsynaptic Density Protein 95 Clustering Positive Regulation Of Dendritic Spine Maintenance	Meiotic Spindle Organization DNA Repair Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II DNA Damage Response Spermatogenesis Regulation Of Cell Cycle Process Positive Regulation Of Nuclear Cell Cycle DNA Replication DNA Damage Response, Signal Transduction By P53 Class Mediator Forebrain Development Replication Fork Processing Subtelomeric Heterochromatin Formation Positive Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Post-embryonic Forelimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Transcription By RNA Polymerase II Sertoli Cell Development Chromosome Organization Involved In Meiotic Cell Cycle Protein Localization To Chromosome, Telomeric Region Seminiferous Tubule Development Cellular Response To Hydroxyurea Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric
Pathways		None	Inhibition of DNA recombination at telomere Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations
Diseases		None	Non-syndromic X-linked mental retardation Thalassemia; Alpha thalassemia; Beta thalassemia; Alpha thalassemia, X-linked (ATRX) Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Bipolar disorder ( 34099189 ) Caffeine consumption from coffee ( 33287642 ) Daytime nap ( 33568662 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Mean platelet volume ( 27863252 32888494 ) Metabolite levels ( 23823483 ) Migraine ( 27182965 ) Parahippocampal gyrus volume ( 31530798 ) Platelet distribution width ( 32888494 ) Response to protease inhibitor treatment in hepatitis c (bilirubin toxicity) ( 24503447 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Platelet count ( 32888494 ) Plateletcrit ( 32888494 )
Novel Interactors		None recorded	1 novel interactors: ATP1A3
Interacting Genes		17 interacting genes: ATN1 ATRX CSNK1E ERBB2 FHOD1 FMR1 FXR2 MEOX2 PBXIP1 PRKCB RERE SPOP SUMO2 USP7 WDR4 ZBTB7A ZFYVE9	33 interacting genes: ATN1 AURKA BLM BRD9 CALM1 CBS CCSER2 CEP126 CLIC6 CREBBP DAXX DSCAM EZH2 H3C14 HDAC1 HDAC4 LUC7L2 MDM2 NEK1 NSD1 PTN PTPN4 RAD51 RAD51AP1 RASSF1 RBM11 SLX9 SUMO2 SVIL WRN ZBED1 ZMYND8 ZNF512B
Entrez ID		23613	546
HPRD ID		10166	02069
Ensembl ID		ENSG00000101040	ENSG00000085224
Uniprot IDs		A0A087WVZ6 A6H8Y8 Q2HXV5 Q569J9 Q9ULU4	A4LAA3 B4DLW1 P46100
PDB IDs		4COS 5B73 5MQ4 5Y1Z 7CWH	2JM1 2LBM 2LD1 3QL9 3QLA 3QLC 3QLN 4W5A 5GRQ 5Y18 5Y6O 6G0O
GO Terms Enriched among Interactors		Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Nucleus Positive Regulation Of RNA Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Biosynthetic Process Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Proteolysis Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Proteasomal Protein Catabolic Process DNA Damage Response Chromatin Organization DNA Repair Translation Regulator Activity Transcription Coactivator Activity PML Body Positive Regulation Of Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Nuclear Androgen Receptor Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromatin Remodeling Presynaptic Cytosol Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Translation Negative Regulation Of Metabolic Process DNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Transport Of Viral Material Gene Expression Involved In Extracellular Matrix Organization	Nucleoplasm SUMO Transferase Activity Recombinational Repair P53 Binding Double-strand Break Repair Via Homologous Recombination Cellular Response To Ionizing Radiation Transcription Corepressor Activity Nucleus Cellular Response To Radiation PML Body Forked DNA-dependent Helicase Activity Chromatin Remodeling Chromatin Organization Protein Sumoylation Chromatin Double-strand Break Repair Cellular Response To Stress Chromosome DNA Recombination Response To Ionizing Radiation Regulation Of Cell Cycle Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Division Telomeric D-loop Binding Y-form DNA Binding Chromosome, Telomeric Region Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Gamma Radiation Centrosome Cellular Response To Camptothecin Cellular Response To Alkaloid Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Four-way Junction Helicase Activity Response To Glycoside Replication Fork Processing Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Striated Muscle Cell Differentiation Pronucleus Positive Regulation Of Metabolic Process DNA Geometric Change Bubble DNA Binding Positive Regulation Of Macromolecule Metabolic Process DNA Damage Response Enzyme Binding