CSF3R and HPCA

Data Source: HiPPIP (Novel)

		CSF3R	HPCA
Name		colony stimulating factor 3 receptor	hippocalcin
Structure
GO Annotations	Cellular Component	Extracellular Region Lysosomal Membrane Plasma Membrane External Side Of Plasma Membrane Membrane Endocytic Vesicle Membrane Receptor Complex	Cytoplasm Cytosol Membrane Axon Dendrite Membrane Neuronal Cell Body Membrane Dendrite Cytoplasm Perikaryon Dendritic Spine Head Postsynapse Glutamatergic Synapse
	Molecular Function	Cytokine Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity Granulocyte Colony-stimulating Factor Binding	Actin Binding Calcium Ion Binding Protein Binding Kinase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Defense Response Cell Adhesion Signal Transduction Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Regulation Of Myeloid Cell Differentiation Amelogenesis	Regulation Of Signal Transduction Calcium-mediated Signaling Inner Ear Development Retina Development In Camera-type Eye Cellular Response To Electrical Stimulus Cellular Response To Calcium Ion Positive Regulation Of Protein Targeting To Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Voltage-gated Calcium Channel Activity Response To Ketamine Response To L-glutamate Response To Aroclor 1254 Cellular Response To L-glutamate
Pathways		Other interleukin signaling Transcriptional regulation of granulopoiesis Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling	None
Drugs		Pegfilgrastim Filgrastim FavId Lenograstim Lipegfilgrastim Eflapegrastim	None
GWAS		Basophil count ( 32888494 ) Cerebrospinal fluid p-tau levels ( 29274321 ) Cerebrospinal fluid t-tau levels ( 29274321 ) Eosinophil percentage of white cells ( 32888494 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Iron status biomarkers (total iron binding capacity) ( 28334935 ) Iron status biomarkers (transferrin saturation) ( 28334935 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Metabolite levels ( 23823483 ) Monocyte percentage of white cells ( 27863252 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 32888494 ) Neutrophil percentage of white cells ( 27863252 32888494 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 27863252 29403010 32888494 )	Daytime nap ( 33568662 )
Novel Interactors		1 novel interactors: HPCA	12 novel interactors: APC BMP8B CSF3R DPYD E2F2 NDC80 NUDC RAE1 RUNX3 TMEM54 TNFRSF8 TUBA4A
Interacting Genes		19 interacting genes: CISH CSF3 ELANE FTH1 GRB2 HCK INPP5D JAK1 JAK2 LCK LYN PLA2G1B PTPN11 SHC1 SOCS3 STAT3 SYK WSB1 WSB2	17 interacting genes: AP2B1 C1QTNF2 CKMT1A CKMT1B CREM DTX2 GATA5 IL36RN MLLT10 MYDGF NAIP NMT1 PRR35 SLC16A3 TEPSIN UQCRB VWC2
Entrez ID		1441	3208
HPRD ID		00737	00811
Ensembl ID		ENSG00000119535	ENSG00000121905
Uniprot IDs		Q99062	P84074
PDB IDs		2D9Q	5G4P 5G58 5M6C 7OWM
GO Terms Enriched among Interactors		Intracellular Signal Transduction Phosphotyrosine Residue Binding Cytokine-mediated Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Immune Effector Process Negative Regulation Of Defense Response Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell-cell Adhesion Interleukin-6-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Signaling Receptor Binding Regulation Of Defense Response Immune System Process Growth Hormone Receptor Signaling Pathway Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of MAPK Cascade Regulation Of Immune System Process Positive Regulation Of Immune Response Positive Regulation Of MAPK Cascade Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Cell Population Proliferation Response To External Biotic Stimulus Positive Regulation Of Cell Adhesion Negative Regulation Of Inflammatory Response Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Cytosol Response To Other Organism Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Intracellular Signal Transduction Phosphorylation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Signaling Leukocyte Migration Positive Regulation Of Cell Activation Regulation Of Cell Communication T Cell Costimulation Regulation Of Inflammatory Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of T Cell Activation	Phosphocreatine Biosynthetic Process Creatine Kinase Activity