CAMK2A and DAPK2

Number of citations of the paper that reports this interaction (PMID 10629061)
24

Data Source:
HPRD (in vitro)

		CAMK2A	DAPK2
Gene Name		calcium/calmodulin-dependent protein kinase II alpha	death-associated protein kinase 2
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol Plasma Membrane Cell Junction Endocytic Vesicle Membrane Presynaptic Membrane	Cytoplasm Cytoplasmic Vesicle Autophagic Vacuole Lumen
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Glutamate Receptor Binding Protein Homodimerization Activity	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Synaptic Transmission Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Peptidyl-serine Phosphorylation Cytokine-mediated Signaling Pathway Cellular Response To Heat Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process	Protein Phosphorylation Apoptotic Process Regulation Of Autophagy Intracellular Signal Transduction Regulation Of Apoptotic Process Anoikis Protein Autophosphorylation Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress Signaling by Wnt CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors beta-catenin independent WNT signaling Interferon gamma signaling HSF1-dependent transactivation Ca2+ pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses	Programmed Cell Death Role of DCC in regulating apoptosis Extrinsic Pathway
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		40 interactors: ACTN1 ACTN2 ACTN4 ATF1 ATP2A2 CAMK2N2 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DLG1 EGFR ETS1 GFAP GRIN1 GRIN2A GRIN2B HSF1 ITGA2B ITGB1BP1 ITPKA KRT18 LRRC7 MAPT MPDZ NOS1 PDC PPM1F PSMC5 PTTG1 RCHY1 RIMS1 SMAD2 SQSTM1 SRF SYNGAP1 TANC1 YWHAB	5 interactors: APP CAMK2A FAM9B MLC1 TGFBR1
Entrez ID		815	23604
HPRD ID		06532	09905
Ensembl ID		ENSG00000070808	ENSG00000035664
Uniprot IDs		A8K161 Q7LDD5 Q8IWE0 Q9UQM7	Q9UIK4
PDB IDs		2VZ6 3SOA	1WMK 1WRZ 1Z9X 1ZUZ 1ZWS 2A27 2A2A 2CKE
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Transmission Cell Projection Organization Neurogenesis Nervous System Development Anatomical Structure Development Generation Of Neurons Cell Differentiation Developmental Process Response To Stimulus Regulation Of Synaptic Plasticity Neuron Projection Development Regulation Of Apoptotic Process Locomotion Regulation Of Cell Death Neuron Differentiation Regulation Of Signaling Regulation Of Cellular Process Neuron Development Single-organism Behavior Regulation Of Cellular Component Organization Positive Regulation Of Cellular Metabolic Process Cell Communication Pons Maturation Movement Of Cell Or Subcellular Component Regulation Of Metabolic Process Positive Regulation Of Gene Expression System Development Positive Regulation Of Metabolic Process Learning Or Memory Cellular Response To Stimulus Signaling Cognition Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Anatomical Structure Morphogenesis Response To External Stimulus Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Response To Abiotic Stimulus Learning Regulation Of Cellular Component Movement Response To Wounding Axonogenesis Regulation Of Neuron Projection Development Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Axon Guidance Axon Development Regulation Of Membrane Potential	Response To Cholesterol Positive Regulation Of Transport Peptidyl-serine Phosphorylation Regulation Of Protein Binding Apoptotic Process Programmed Cell Death Synaptic Growth At Neuromuscular Junction Regulation Of Cellular Localization Cell Death Death Collateral Sprouting In Absence Of Injury Positive Regulation Of Intracellular Transport Protein Phosphorylation Regulation Of Binding Caveolin-mediated Endocytosis Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Movement Of Cell Or Subcellular Component Positive Regulation Of Catalytic Activity Axon Choice Point Recognition Parathyroid Gland Development Regulation Of Response To Osmotic Stress Extracellular Matrix Organization Extracellular Structure Organization Neuron Remodeling Phosphorylation Cellular Response To Organic Substance Endothelial Cell Activation Regulation Of Intracellular Transport Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Cholesterol Regulation Of SMAD Protein Import Into Nucleus Immune System Process Cellular Response To Sterol Germ Cell Migration Cellular Copper Ion Homeostasis Pharyngeal System Development Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Wound Healing Copper Ion Homeostasis Suckling Behavior Regulation Of Catalytic Activity Regulation Of Growth Positive Regulation Of Cell Death Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Tagcloud ?		acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene translating tta	ablation avenue bullet correspondingly dr dr4 dr5 druggable hailed imminently impetuous indeed issues kill killing magic modulator offer overcome proapoptotic reappraised sensitisation signalling targetable tolerated trail trigger unfortunately usable
Tagcloud (Difference) ?		acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene translating tta	ablation avenue bullet correspondingly dr dr4 dr5 druggable hailed imminently impetuous indeed issues kill killing magic modulator offer overcome proapoptotic reappraised sensitisation signalling targetable tolerated trail trigger unfortunately usable
Tagcloud (Intersection) ?