CAMK2A and CACNA1B

Number of citations of the paper that reports this interaction (PubMedID 28130356)
100

Data Source:
BioGRID (pull down)

		CAMK2A	CACNA1B
Description		calcium/calmodulin dependent protein kinase II alpha	calcium voltage-gated channel subunit alpha1 B
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Dendrite Endocytic Vesicle Membrane Cell Projection Neuron Projection Dendritic Spine Synapse	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Neuronal Cell Body Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Glutamate Receptor Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Amyloid-beta Binding Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding High Voltage-gated Calcium Channel Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Interferon-beta Angiotensin-activated Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Hydrolase Activity Positive Regulation Of Calcium Ion Transport Long-term Synaptic Potentiation Dendritic Spine Development Cellular Response To Type II Interferon Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Protein Localization To Plasma Membrane Peptidyl-threonine Autophosphorylation Regulation Of Endocannabinoid Signaling Pathway Regulation Of Neuron Migration	Monoatomic Ion Transport Calcium Ion Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Response To Amyloid-beta
Pathways		CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Ca2+ pathway Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Presynaptic depolarization and calcium channel opening
Drugs		Hexatantalum Dodecabromide 1,4-Dithiothreitol (2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime} Fostamatinib	Eptifibatide Ergocalciferol Enflurane Amlodipine Amlodipine Spironolactone Nicardipine Verapamil Verapamil Gabapentin Levetiracetam Seletracetam Contulakin-G Ziconotide Agmatine Benidipine Cilnidipine Efonidipine Butamben Bioallethrin
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Inflammatory bowel disease ( 28067908) Obesity-related traits ( 23251661) Retinitis pigmentosa ( 33514863) Ulcerative colitis ( 28067908)	Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Bipolar disorder ( 31043756) Body mass index ( 28552196) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Parkinson's disease ( 32201043) Weight ( 28552196)
Interacting Genes		89 interacting genes: ACTN1 ACTN2 ACTN4 ARID5A ATF1 ATP2A2 C1orf94 CACNA1B CAMK2N2 CDC37 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DAZAP2 DLG1 DSCAM EGFR ETS1 FAM168A FAM168B FXR1 GFAP GLB1L2 GRIA1 GRIN1 GRIN2A GRIN2B GRM5 HSF1 HYAL3 ITGA2B ITGB1BP1 ITPKA KRT18 KRT75 KRT76 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP22-1 KRTAP23-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LASP1 LENG8 LRRC7 MAPT MPDZ MRPL11 NOS1 NTAQ1 PDC PPM1F PSMC5 PTTG1 RALYL RBFOX2 RBM47 RBPMS RBPMS2 RCHY1 RHOXF2 RIMS1 SMAD2 SOX5 SPMIP9 SQSTM1 SRF STAT1 SUOX SYNGAP1 TAB2 TANC1 TCAF1 TFAP2D TIAL1 TRIM55 TRIM63 TSR2 TTC5 VARS1 YWHAB ZBTB32	10 interacting genes: APBA1 CACNB3 CAMK2A GNAO1 GNB1 PDLIM5 PPM1A RGS12 RIMS1 RXRB
Entrez ID		815	774
HPRD ID		06532	03005
Ensembl ID		ENSG00000070808	ENSG00000148408
Uniprot IDs		A0A5F9ZH21 A8K161 Q7LDD5 Q8IWE0 Q9UQM7	Q00975
PDB IDs		2VZ6 3SOA 5IG3 6OF8 6VZK 6W4O 6W4P 6X5G 6X5Q 7KL0 7KL1 7KL2 7REC 7UIQ 7UIR 7UIS 7UJP 7UJQ 7UJR 7UJS 7UJT 9EOY	2LCM 7MIX 7MIY 7VFS 7VFU 7VFV 7VFW
Enriched GO Terms of Interacting Partners?		Intermediate Filament Regulation Of Synaptic Plasticity Dendritic Spine Modulation Of Chemical Synaptic Transmission Learning Or Memory Cognition Postsynaptic Density Glutamate-gated Calcium Ion Channel Activity Identical Protein Binding Neuron Projection Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Excitatory Postsynaptic Potential Associative Learning Positive Regulation Of Synaptic Transmission Synapse Postsynaptic Density Membrane Intracellular Signaling Cassette Learning Ligand-gated Ion Channel Signaling Pathway Regulation Of Membrane Potential Cytosol NMDA Glutamate Receptor Activity Cell Junction Organization Modulation Of Excitatory Postsynaptic Potential Transmembrane Transporter Binding Positive Regulation Of Macromolecule Biosynthetic Process Visual Learning Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling NMDA Selective Glutamate Receptor Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Synaptic Signaling Regulation Of Postsynaptic Membrane Potential Postsynaptic Actin Cytoskeleton Excitatory Chemical Synaptic Transmission Kinase Binding Visual Behavior Positive Regulation Of Biosynthetic Process Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Nucleobase-containing Compound Metabolic Process Synaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Protein Kinase Binding Regulation Of Nucleobase-containing Compound Metabolic Process Superior Olivary Nucleus Maturation	Synapse Modulation Of Chemical Synaptic Transmission G Protein-coupled Dopamine Receptor Signaling Pathway GTPase Regulator Activity Heterotrimeric G-protein Complex Cytosol Vesicle Docking Involved In Exocytosis Regulation Of Cell Communication Regulation Of Signaling Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Transport Positive Regulation Of High Voltage-gated Calcium Channel Activity Peptidyl-threonine Autophosphorylation G Protein-coupled Receptor Signaling Pathway Regulation Of Neurotransmitter Secretion Mu-type Opioid Receptor Binding Membrane Docking GTPase Activity Vesicle Docking Organelle Localization By Membrane Tethering Regulation Of Endocannabinoid Signaling Pathway G Protein-coupled Serotonin Receptor Binding Cytoplasm Dendrite Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity N-terminal Protein Myristoylation Dendritic Spine Gamma-aminobutyric Acid Secretion Intracellular Protein Transport Positive Regulation Of Voltage-gated Calcium Channel Activity Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Presynaptic Membrane Calmodulin-dependent Protein Phosphatase Activity Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Vitamin D Receptor Signaling Pathway Acrosomal Vesicle Exocytosis Positive Regulation Of Inhibitory Postsynaptic Potential Regulation Of Secretion By Cell Glutamate Receptor Binding Cell Projection Retinoic Acid-responsive Element Binding Structural Constituent Of Presynaptic Active Zone Modulation Of Inhibitory Postsynaptic Potential
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