CAMK2A and TTC5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CAMK2A	TTC5
Description		calcium/calmodulin dependent protein kinase II alpha	tetratricopeptide repeat domain 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Dendrite Endocytic Vesicle Membrane Cell Projection Neuron Projection Dendritic Spine Synapse	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Glutamate Receptor Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity	DNA Binding Chromatin Binding Protein Binding Ribosome Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Interferon-beta Angiotensin-activated Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Hydrolase Activity Positive Regulation Of Calcium Ion Transport Long-term Synaptic Potentiation Dendritic Spine Development Cellular Response To Type II Interferon Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Protein Localization To Plasma Membrane Peptidyl-threonine Autophosphorylation Regulation Of Endocannabinoid Signaling Pathway Regulation Of Neuron Migration	DNA Repair DNA Damage Response Cellular Response To Starvation Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of MRNA Catabolic Process
Pathways		CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Ca2+ pathway Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Regulation of TP53 Activity through Methylation
Drugs		Hexatantalum Dodecabromide 1,4-Dithiothreitol (2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime} Fostamatinib
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Inflammatory bowel disease ( 28067908) Obesity-related traits ( 23251661) Retinitis pigmentosa ( 33514863) Ulcerative colitis ( 28067908)	Alzheimer's disease progression score ( 29860282)
Interacting Genes		89 interacting genes: ACTN1 ACTN2 ACTN4 ARID5A ATF1 ATP2A2 C1orf94 CACNA1B CAMK2N2 CDC37 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DAZAP2 DLG1 DSCAM EGFR ETS1 FAM168A FAM168B FXR1 GFAP GLB1L2 GRIA1 GRIN1 GRIN2A GRIN2B GRM5 HSF1 HYAL3 ITGA2B ITGB1BP1 ITPKA KRT18 KRT75 KRT76 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP22-1 KRTAP23-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LASP1 LENG8 LRRC7 MAPT MPDZ MRPL11 NOS1 NTAQ1 PDC PPM1F PSMC5 PTTG1 RALYL RBFOX2 RBM47 RBPMS RBPMS2 RCHY1 RHOXF2 RIMS1 SMAD2 SOX5 SPMIP9 SQSTM1 SRF STAT1 SUOX SYNGAP1 TAB2 TANC1 TCAF1 TFAP2D TIAL1 TRIM55 TRIM63 TSR2 TTC5 VARS1 YWHAB ZBTB32	9 interacting genes: CAMK2A CAMK2B CAMK2D CAMK2G CAVIN1 DDIT4L GOLGA6A HDX JMY
Entrez ID		815	91875
HPRD ID		06532	15584
Ensembl ID		ENSG00000070808	ENSG00000136319
Uniprot IDs		A0A5F9ZH21 A8K161 Q7LDD5 Q8IWE0 Q9UQM7	Q86T04 Q8N0Z6
PDB IDs		2VZ6 3SOA 5IG3 6OF8 6VZK 6W4O 6W4P 6X5G 6X5Q 7KL0 7KL1 7KL2 7REC 7UIQ 7UIR 7UIS 7UJP 7UJQ 7UJR 7UJS 7UJT 9EOY	2XVS 6T59 7QWS 8BPO
Enriched GO Terms of Interacting Partners?		Intermediate Filament Regulation Of Synaptic Plasticity Dendritic Spine Modulation Of Chemical Synaptic Transmission Learning Or Memory Cognition Postsynaptic Density Glutamate-gated Calcium Ion Channel Activity Identical Protein Binding Neuron Projection Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Excitatory Postsynaptic Potential Associative Learning Positive Regulation Of Synaptic Transmission Synapse Postsynaptic Density Membrane Intracellular Signaling Cassette Learning Ligand-gated Ion Channel Signaling Pathway Regulation Of Membrane Potential Cytosol NMDA Glutamate Receptor Activity Cell Junction Organization Modulation Of Excitatory Postsynaptic Potential Transmembrane Transporter Binding Positive Regulation Of Macromolecule Biosynthetic Process Visual Learning Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling NMDA Selective Glutamate Receptor Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Synaptic Signaling Regulation Of Postsynaptic Membrane Potential Postsynaptic Actin Cytoskeleton Excitatory Chemical Synaptic Transmission Kinase Binding Visual Behavior Positive Regulation Of Biosynthetic Process Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Nucleobase-containing Compound Metabolic Process Synaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Protein Kinase Binding Regulation Of Nucleobase-containing Compound Metabolic Process Superior Olivary Nucleus Maturation	Calcium- And Calmodulin-dependent Protein Kinase Complex Calcium/calmodulin-dependent Protein Kinase Activity Long-term Synaptic Potentiation Regulation Of Neuronal Synaptic Plasticity Endocytic Vesicle Membrane Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Synaptic Transmission Regulation Of Protein Localization To Cell Periphery Sarcoplasmic Reticulum Membrane Regulation Of Protein Localization To Membrane Calmodulin Binding Regulation Of Synaptic Plasticity Regulation Of Calcium Ion Transport Sarcoplasmic Reticulum Postsynaptic Density Regulation Of Skeletal Muscle Adaptation Neuron Projection Regulation Of Metal Ion Transport Protein Serine Kinase Activity Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Protein Serine/threonine Kinase Activity Regulation Of Monoatomic Ion Transport Modulation Of Chemical Synaptic Transmission Protein Kinase Activity Regulation Of Cellular Localization Kinase Activity Regulation Of Muscle System Process Regulation Of Neuron Migration Regulation Of Cardiac Muscle Cell Apoptotic Process Protein Homodimerization Activity Peptidyl-threonine Autophosphorylation 'de Novo' Actin Filament Nucleation Protein Phosphorylation Regulation Of Protein Localization Phosphorylation Identical Protein Binding Regulation Of Endocannabinoid Signaling Pathway Calcium-dependent Protein Serine/threonine Phosphatase Activity Termination Of RNA Polymerase I Transcription RRNA Primary Transcript Binding Protein Autophosphorylation Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Protein Secretion Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of System Process Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Relaxation Of Cardiac Muscle Glutamate Receptor Binding
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