CAMK2A and CHAT

Number of citations of the paper that reports this interaction (PubMedID 10861222)
30

Data Source:
HPRD (in vitro, in vivo)

		CAMK2A	CHAT
Description		calcium/calmodulin dependent protein kinase II alpha	choline O-acetyltransferase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Dendrite Endocytic Vesicle Membrane Cell Projection Neuron Projection Dendritic Spine Synapse	Nucleus Cytoplasm Cytosol Neuron Projection Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Glutamate Receptor Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity	Choline O-acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Interferon-beta Angiotensin-activated Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Hydrolase Activity Positive Regulation Of Calcium Ion Transport Long-term Synaptic Potentiation Dendritic Spine Development Cellular Response To Type II Interferon Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Protein Localization To Plasma Membrane Peptidyl-threonine Autophosphorylation Regulation Of Endocannabinoid Signaling Pathway Regulation Of Neuron Migration	Phosphatidylcholine Biosynthetic Process Neurotransmitter Transport Neuromuscular Synaptic Transmission Acetylcholine Biosynthetic Process
Pathways		CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Ca2+ pathway Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Synthesis of PC Acetylcholine Neurotransmitter Release Cycle
Drugs		Hexatantalum Dodecabromide 1,4-Dithiothreitol (2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime} Fostamatinib	Nicotine
Diseases			Congenital myasthenic syndrome
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Inflammatory bowel disease ( 28067908) Obesity-related traits ( 23251661) Retinitis pigmentosa ( 33514863) Ulcerative colitis ( 28067908)	Glaucoma (primary angle closure) ( 27064256) Interleukin-1-receptor antagonist levels ( 22205395) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Type 2 diabetes nephropathy ( 30566433)
Interacting Genes		89 interacting genes: ACTN1 ACTN2 ACTN4 ARID5A ATF1 ATP2A2 C1orf94 CACNA1B CAMK2N2 CDC37 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DAZAP2 DLG1 DSCAM EGFR ETS1 FAM168A FAM168B FXR1 GFAP GLB1L2 GRIA1 GRIN1 GRIN2A GRIN2B GRM5 HSF1 HYAL3 ITGA2B ITGB1BP1 ITPKA KRT18 KRT75 KRT76 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP22-1 KRTAP23-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LASP1 LENG8 LRRC7 MAPT MPDZ MRPL11 NOS1 NTAQ1 PDC PPM1F PSMC5 PTTG1 RALYL RBFOX2 RBM47 RBPMS RBPMS2 RCHY1 RHOXF2 RIMS1 SMAD2 SOX5 SPMIP9 SQSTM1 SRF STAT1 SUOX SYNGAP1 TAB2 TANC1 TCAF1 TFAP2D TIAL1 TRIM55 TRIM63 TSR2 TTC5 VARS1 YWHAB ZBTB32	9 interacting genes: CAMK2A CAMK2G NEDD9 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ
Entrez ID		815	1103
HPRD ID		06532	07510
Ensembl ID		ENSG00000070808	ENSG00000070748
Uniprot IDs		A0A5F9ZH21 A8K161 Q7LDD5 Q8IWE0 Q9UQM7	P28329 Q6LEN5 Q6LEN6
PDB IDs		2VZ6 3SOA 5IG3 6OF8 6VZK 6W4O 6W4P 6X5G 6X5Q 7KL0 7KL1 7KL2 7REC 7UIQ 7UIR 7UIS 7UJP 7UJQ 7UJR 7UJS 7UJT 9EOY	2FY2 2FY3 2FY4 2FY5 7AMD
Enriched GO Terms of Interacting Partners?		Intermediate Filament Regulation Of Synaptic Plasticity Dendritic Spine Modulation Of Chemical Synaptic Transmission Learning Or Memory Cognition Postsynaptic Density Glutamate-gated Calcium Ion Channel Activity Identical Protein Binding Neuron Projection Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Excitatory Postsynaptic Potential Associative Learning Positive Regulation Of Synaptic Transmission Synapse Postsynaptic Density Membrane Intracellular Signaling Cassette Learning Ligand-gated Ion Channel Signaling Pathway Regulation Of Membrane Potential Cytosol NMDA Glutamate Receptor Activity Cell Junction Organization Modulation Of Excitatory Postsynaptic Potential Transmembrane Transporter Binding Positive Regulation Of Macromolecule Biosynthetic Process Visual Learning Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling NMDA Selective Glutamate Receptor Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Synaptic Signaling Regulation Of Postsynaptic Membrane Potential Postsynaptic Actin Cytoskeleton Excitatory Chemical Synaptic Transmission Kinase Binding Visual Behavior Positive Regulation Of Biosynthetic Process Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Nucleobase-containing Compound Metabolic Process Synaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Protein Kinase Binding Regulation Of Nucleobase-containing Compound Metabolic Process Superior Olivary Nucleus Maturation	Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Protein Phosphorylation Long-term Synaptic Potentiation Phosphorylation Regulation Of Synaptic Plasticity ATP Binding Regulation Of Protein Localization Histone H3T6 Kinase Activity Nucleotide Binding Regulation Of Biological Quality Transferase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Positive Regulation Of Protein Localization Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of Cell Communication Regulation Of Signaling Regulation Of Transport Positive Regulation Of Immune System Process Regulation Of Secretion By Cell Positive Regulation Of Protein Transport Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Regulation Of Secretion Response To Hormone Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Neurotransmitter Secretion Positive Regulation Of Insulin Secretion Mitotic Nuclear Membrane Disassembly Response To Peptide Hormone Positive Regulation Of Establishment Of Protein Localization Insulin Receptor Substrate Binding Positive Regulation Of Peptide Hormone Secretion Nuclear Membrane Disassembly Positive Regulation Of Peptide Secretion Membrane Disassembly Phosphate-containing Compound Metabolic Process Regulation Of Protein Localization To Plasma Membrane Response To Morphine
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