TRAM1L1 and PLEKHO1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TRAM1L1	PLEKHO1
Name		translocation associated membrane protein 1 like 1	pleckstrin homology domain containing O1
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleus Cytoplasm Plasma Membrane Membrane Ruffle Membrane Muscle Cell Projection Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Protein Transport Protein Insertion Into ER Membrane	Myoblast Fusion Regulation Of Cell Shape Myoblast Migration Lamellipodium Morphogenesis Regulation Of Myoblast Fusion
GWAS		Bipolar disorder ( 33169155 ) Bronchopulmonary dysplasia ( 23897914 ) Lateral ventricle volume in trauma-exposed individuals ( 29187748 ) Metabolite levels ( 23823483 ) Obesity (extreme) ( 19553259 ) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 ) Visceral adipose tissue adjusted for BMI ( 22589738 )	Bipolar disorder ( 31043756 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 29483656 )
Novel Interactors		None recorded	7 novel interactors: ADAMTSL4 C1orf56 CDC42SE1 GOLPH3L RPRD2 SMG5 SYT11
Interacting Genes		29 interacting genes: ASGR2 BDKRB1 BSCL2 CD53 CD79A CD99L2 CLEC1A CLSTN3 CREB3 CREB3L1 CYBC1 ERGIC3 EVI2B FAM209A FKBP7 GPX8 HTR2B LMNA LRRC59 MFF MUC1 PLEKHF2 PLEKHO1 PLPP2 SAR1A TMED8 TMEM52B TMEM79 TMX2	33 interacting genes: ADAM33 AKT1 AKT2 ARLN BNIP2 BRICD5 C10orf88 CEP19 COL8A2 CSNK2A1 CYP4F2 DNAJB1 FLNB IFI35 LRP10 MMD NAPB OGT PSMC5 RPS20 SMAD5 SMURF1 THSD7B TMEM218 TNF TRAF3IP3 TRAF6 TRAM1L1 TSPAN33 TSPO2 USP7 VAMP3 ZFPL1
Entrez ID		133022	51177
HPRD ID		11643	12217
Ensembl ID		ENSG00000174599	ENSG00000023902
Uniprot IDs		Q8N609	Q53GL0 Q5T4P9
PDB IDs		Not available	3AA1
GO Terms Enriched among Interactors		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane	Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Negative Regulation Of Fatty Acid Transport Positive Regulation Of Translational Initiation Regulation Of Translational Initiation Protein Localization To Membrane Symbiont-mediated Disruption Of Host Cell PML Body Localization Within Membrane Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Fatty Acid Transport Positive Regulation Of Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Glucose Metabolic Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Lipid Transport Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Cellular Localization Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Localization Regulation Of Protein Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of D-glucose Import Positive Regulation Of JUN Kinase Activity Regulation Of Lipid Catabolic Process Membrane Golgi To Plasma Membrane Transport Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Translation Negative Regulation Of Transport TORC1 Signaling Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Vacuole Involved In Autophagy Toll-like Receptor 3 Signaling Pathway Myelin Maintenance Pattern Recognition Receptor Signaling Pathway Regulation Of PERK-mediated Unfolded Protein Response