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OSR1 and TGFBR2
Number of citations of the paper that reports this interaction (PubMedID
15761153
)
0
Data Source:
HPRD
(in vivo)
OSR1
TGFBR2
Description
odd-skipped related transcription factor 1
transforming growth factor beta receptor 2
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Cytosol
Cell Cortex
Extracellular Region
Extracellular Space
Cytosol
Plasma Membrane
Caveola
External Side Of Plasma Membrane
Cell Surface
Membrane
Nuclear Body
Receptor Complex
Membrane Raft
Activin Receptor Complex
Transforming Growth Factor Beta Ligand-receptor Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Zinc Ion Binding
Metal Ion Binding
Transporter Inhibitor Activity
Sequence-specific Double-stranded DNA Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type II
Protein Binding
ATP Binding
Glycosaminoglycan Binding
Kinase Activity
Activin Receptor Activity, Type I
Transferase Activity
Kinase Activator Activity
Type I Transforming Growth Factor Beta Receptor Binding
Type III Transforming Growth Factor Beta Receptor Binding
Signaling Receptor Activity
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
Molecular Adaptor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Urogenital System Development
Metanephros Development
Ureteric Bud Development
Mesonephros Development
Chondrocyte Differentiation
Pattern Specification Process
Heart Development
Gonad Development
Positive Regulation Of Gene Expression
Cell Differentiation
Positive Regulation Of Bone Mineralization
Negative Regulation Of Epithelial Cell Differentiation
Negative Regulation Of Transmembrane Transport
Embryonic Forelimb Morphogenesis
Embryonic Hindlimb Morphogenesis
Sodium Ion Transmembrane Transport
Embryonic Skeletal Limb Joint Morphogenesis
Middle Ear Morphogenesis
Odontogenesis
Embryonic Digit Morphogenesis
Negative Regulation Of Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Intermediate Mesoderm Development
Pronephros Development
Stem Cell Differentiation
Positive Regulation Of Epithelial Cell Proliferation
Roof Of Mouth Development
Embryonic Skeletal Joint Morphogenesis
Cellular Response To Retinoic Acid
Metanephric Mesenchyme Development
Cell Proliferation Involved In Kidney Development
Metanephric Mesenchyme Morphogenesis
Mesangial Cell Development
Metanephric Mesenchymal Cell Differentiation
Posterior Mesonephric Tubule Development
Specification Of Anterior Mesonephric Tubule Identity
Specification Of Posterior Mesonephric Tubule Identity
Mesonephric Duct Morphogenesis
Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation
Renal Vesicle Progenitor Cell Differentiation
Ureter Urothelium Development
Metanephric Epithelium Development
Metanephric Smooth Muscle Tissue Development
Metanephric Nephron Tubule Development
Metanephric Glomerulus Vasculature Development
Metanephric Interstitial Fibroblast Development
Pattern Specification Involved In Metanephros Development
Embryonic Skeletal Joint Development
Metanephric Cap Mesenchymal Cell Proliferation Involved In Metanephros Development
Negative Regulation Of Sodium Ion Transmembrane Transport
Positive Regulation Of Gastrulation
Blood Vessel Development
Branching Involved In Blood Vessel Morphogenesis
Vasculogenesis
In Utero Embryonic Development
Epithelial To Mesenchymal Transition
Heart Looping
Positive Regulation Of Mesenchymal Cell Proliferation
Lens Development In Camera-type Eye
Positive Regulation Of Tolerance Induction To Self Antigen
Positive Regulation Of B Cell Tolerance Induction
Positive Regulation Of T Cell Tolerance Induction
Outflow Tract Septum Morphogenesis
Membranous Septum Morphogenesis
Outflow Tract Morphogenesis
Aortic Valve Morphogenesis
Atrioventricular Valve Morphogenesis
Tricuspid Valve Morphogenesis
Cardiac Left Ventricle Morphogenesis
Endocardial Cushion Fusion
Growth Plate Cartilage Development
Growth Plate Cartilage Chondrocyte Growth
Apoptotic Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Notch Signaling Pathway
Smoothened Signaling Pathway
Gastrulation
Nervous System Development
Brain Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial To Mesenchymal Transition
Cell Differentiation
Lung Development
Activin Receptor Signaling Pathway
Response To Lipid
Embryonic Hemopoiesis
Aorta Morphogenesis
Regulation Of Cell Population Proliferation
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Angiogenesis
Animal Organ Development
Blood Vessel Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Artery Morphogenesis
Positive Regulation Of Developmental Process
Positive Regulation Of NK T Cell Differentiation
Cartilage Development
Regulation Of Multicellular Organismal Process
Roof Of Mouth Development
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Lung Morphogenesis
Bronchus Development
Bronchus Morphogenesis
Trachea Morphogenesis
Trachea Formation
Mammary Gland Morphogenesis
Lung Lobe Morphogenesis
Langerhans Cell Differentiation
Secondary Palate Development
Response To Cholesterol
Cellular Response To Growth Factor Stimulus
Regulation Of Stem Cell Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Cell Proliferation Involved In Endocardial Cushion Morphogenesis
Superior Endocardial Cushion Morphogenesis
Inferior Endocardial Cushion Morphogenesis
Lens Fiber Cell Apoptotic Process
MiRNA Transport
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Regulation Of Stem Cell Differentiation
Pathways
Formation of intermediate mesoderm
Formation of the nephric duct
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
UCH proteinases
TGFBR3 regulates TGF-beta signaling
Drugs
Foreskin fibroblast (neonatal)
Foreskin keratinocyte (neonatal)
Fostamatinib
Diseases
Loeys-Dietz syndrome (LDS)
Colorectal cancer
Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS
Childhood ear infection (
27182965
28928442
)
Coronary artery disease (
32469254
33020668
)
Facial morphology (
29921221
)
Monobrow (
27182965
)
Pulse pressure (
26390057
27841878
28739976
)
Systolic blood pressure (
27841878
)
Breast cancer (
23535729
29059683
)
Cellular nuclear factor (erythroid-derived 2)-like 2 levels (
30767168
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Estimated glomerular filtration rate (
31152163
)
Heel bone mineral density (
30598549
)
Metabolite levels (
23823483
)
Migraine (
22683712
27322543
)
Migraine - clinic-based (
23793025
)
Night sleep phenotypes (
27126917
)
Postprandial triglyceride response (
32603185
)
Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) (
25117820
)
Systolic blood pressure (
30224653
)
Tonometry (
17903302
)
Interacting Genes
3 interacting genes:
CRBN
TGFBR1
TGFBR2
51 interacting genes:
ACVR1
ACVRL1
AP2B1
APP
ARHGEF6
ARHGEF7
CCNB1
CCNB2
CD44
CDK1
CLU
CRIPTO
CTNNB1
DAB2
DAXX
DYNLT4
EIF3I
ENG
FANCC
GOPC
KCNK18
MAP2K1
NRP1
OSR1
PAK1
PDGFRA
PIK3R1
PIK3R2
PML
PPP2CB
PSMD14
RCVRN
SMAD3
SMAD4
SMAD7
SNX6
STRAP
TERT
TGFB1
TGFB1I1
TGFB2
TGFB3
TGFBR1
TGFBR3
TGFBRAP1
TRAP1
TRMO
TSSK1B
USP8
ZFYVE9
ZNF510
Entrez ID
130497
7048
HPRD ID
16401
01823
Ensembl ID
ENSG00000143867
ENSG00000163513
Uniprot IDs
Q8TAX0
A0AAQ5BI06
A3QNQ0
D2JYI1
P37173
PDB IDs
1KTZ
1M9Z
1PLO
2PJY
3KFD
4P7U
4XJJ
5E8V
5E8Y
5E91
5E92
5QIN
5TX4
5TY4
7DV6
8G4K
8YGZ
9B9F
9E9G
9FDY
9FK5
9FKP
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Transforming Growth Factor Beta Ligand-receptor Complex
Activin Receptor Complex
Activin Receptor Activity, Type I
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Transforming Growth Factor Beta Receptor Activity
Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition
Activin Binding
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Binding
Response To Cholesterol
Embryonic Cranial Skeleton Morphogenesis
Activin Receptor Signaling Pathway
Ventricular Septum Morphogenesis
Positive Regulation Of SMAD Protein Signal Transduction
Lens Development In Camera-type Eye
SMAD Binding
Positive Regulation Of Epithelial To Mesenchymal Transition
Artery Morphogenesis
Regulation Of SMAD Protein Signal Transduction
Cardiac Septum Morphogenesis
Roof Of Mouth Development
Embryonic Skeletal System Morphogenesis
Epithelial To Mesenchymal Transition
Regulation Of Stem Cell Proliferation
Blood Vessel Morphogenesis
Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Mesenchymal Cell Differentiation
Regulation Of Epithelial To Mesenchymal Transition
Skeletal System Morphogenesis
Embryonic Organ Morphogenesis
Cell Proliferation Involved In Endocardial Cushion Morphogenesis
Positive Regulation Of Tolerance Induction To Self Antigen
Superior Endocardial Cushion Morphogenesis
Inferior Endocardial Cushion Morphogenesis
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Vascular Endothelial Cell Proliferation
Epicardium Morphogenesis
Positive Regulation Of Vasculature Development
Bronchus Morphogenesis
Transforming Growth Factor Beta Receptor Activity, Type II
Positive Regulation Of B Cell Tolerance Induction
Mammary Gland Morphogenesis
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Receptor Complex
Membrane Raft
Proepicardium Development
Angiogenesis Involved In Coronary Vascular Morphogenesis
Growth Plate Cartilage Chondrocyte Growth
Transforming Growth Factor Beta Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of SMAD Protein Signal Transduction
Response To Growth Factor
Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
SMAD Binding
Regulation Of Apoptotic Process
Tissue Morphogenesis
Heart Development
Regulation Of Programmed Cell Death
Positive Regulation Of Developmental Process
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Type II Transforming Growth Factor Beta Receptor Binding
Regulation Of Signal Transduction
Tube Morphogenesis
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Transforming Growth Factor Beta Receptor Binding
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Anatomical Structure Morphogenesis
I-SMAD Binding
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Cell Motility
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Locomotion
Regulation Of Developmental Process
Regulation Of Growth
Regulation Of Cell Differentiation
Embryo Development Ending In Birth Or Egg Hatching
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Migration
Multicellular Organism Development
Regulation Of Cellular Component Organization
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Cell Differentiation
Transforming Growth Factor Beta Binding
Mesenchymal Cell Differentiation
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Tagcloud (Intersection)
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