OSR1

Description		odd-skipped related transcription factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytosol Cell Cortex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Zinc Ion Binding Metal Ion Binding Transporter Inhibitor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Urogenital System Development Metanephros Development Ureteric Bud Development Mesonephros Development Chondrocyte Differentiation Pattern Specification Process Heart Development Gonad Development Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Bone Mineralization Negative Regulation Of Epithelial Cell Differentiation Negative Regulation Of Transmembrane Transport Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Sodium Ion Transmembrane Transport Embryonic Skeletal Limb Joint Morphogenesis Middle Ear Morphogenesis Odontogenesis Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Intermediate Mesoderm Development Pronephros Development Stem Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Roof Of Mouth Development Embryonic Skeletal Joint Morphogenesis Cellular Response To Retinoic Acid Metanephric Mesenchyme Development Cell Proliferation Involved In Kidney Development Metanephric Mesenchyme Morphogenesis Mesangial Cell Development Metanephric Mesenchymal Cell Differentiation Posterior Mesonephric Tubule Development Specification Of Anterior Mesonephric Tubule Identity Specification Of Posterior Mesonephric Tubule Identity Mesonephric Duct Morphogenesis Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Renal Vesicle Progenitor Cell Differentiation Ureter Urothelium Development Metanephric Epithelium Development Metanephric Smooth Muscle Tissue Development Metanephric Nephron Tubule Development Metanephric Glomerulus Vasculature Development Metanephric Interstitial Fibroblast Development Pattern Specification Involved In Metanephros Development Embryonic Skeletal Joint Development Metanephric Cap Mesenchymal Cell Proliferation Involved In Metanephros Development Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Gastrulation
Pathways		Formation of intermediate mesoderm Formation of the nephric duct
Drugs
Diseases
GWAS		Childhood ear infection ( 27182965 28928442) Coronary artery disease ( 32469254 33020668) Facial morphology ( 29921221) Monobrow ( 27182965) Pulse pressure ( 26390057 27841878 28739976) Systolic blood pressure ( 27841878)
Interacting Genes		3 interacting genes: CRBN TGFBR1 TGFBR2
Entrez ID		130497
HPRD ID		16401
Ensembl ID		ENSG00000143867
Uniprot IDs		Q8TAX0
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Ligand-receptor Complex Activin Receptor Complex Activin Receptor Activity, Type I Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Binding Response To Cholesterol Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Lens Development In Camera-type Eye SMAD Binding Positive Regulation Of Epithelial To Mesenchymal Transition Artery Morphogenesis Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Roof Of Mouth Development Embryonic Skeletal System Morphogenesis Epithelial To Mesenchymal Transition Regulation Of Stem Cell Proliferation Blood Vessel Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mesenchymal Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Skeletal System Morphogenesis Embryonic Organ Morphogenesis Cell Proliferation Involved In Endocardial Cushion Morphogenesis Positive Regulation Of Tolerance Induction To Self Antigen Superior Endocardial Cushion Morphogenesis Inferior Endocardial Cushion Morphogenesis Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Positive Regulation Of Vasculature Development Bronchus Morphogenesis Transforming Growth Factor Beta Receptor Activity, Type II Positive Regulation Of B Cell Tolerance Induction Mammary Gland Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Receptor Complex Membrane Raft Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Growth Plate Cartilage Chondrocyte Growth
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