MITD1 and CHMP2A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid, in vivo)

		MITD1	CHMP2A
Description		microtubule interacting and trafficking domain containing 1	charged multivesicular body protein 2A
Image
GO Annotations	Cellular Component	Endosome Membrane Midbody Late Endosome Membrane Extracellular Exosome	Autophagosome Membrane Kinetochore Chromatin ESCRT III Complex Nucleus Nuclear Envelope Nuclear Pore Lysosomal Membrane Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Membrane Membrane Coat Midbody Late Endosome Membrane Multivesicular Body Membrane Extracellular Exosome Amphisome Membrane
	Molecular Function	Protein Binding Protein Domain Specific Binding Phosphatidylinositol Binding Identical Protein Binding	Protein Binding Protein Domain Specific Binding Phosphatidylcholine Binding
	Biological Process	Mitotic Cytokinesis Negative Regulation Of Protein Binding Viral Budding Via Host ESCRT Complex Cell Division Midbody Abscission Multivesicular Body Sorting Pathway	Plasma Membrane Repair Autophagy Nucleus Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Membrane Invagination Exit From Mitosis Regulation Of Centrosome Duplication Protein Transport Macroautophagy Viral Release From Host Cell Nuclear Membrane Reassembly Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Protein Localization Late Endosome To Vacuole Transport Viral Budding From Plasma Membrane Protein Polymerization Protein Homooligomerization Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport Positive Regulation Of Exosomal Secretion Negative Regulation Of Centriole Elongation ESCRT III Complex Disassembly
Pathways			Budding and maturation of HIV virion Macroautophagy Lysosome Vesicle Biogenesis Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)	Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		17 interacting genes: ATF7 CARD10 CEBPA CHMP1A CHMP1B CHMP2A CHMP5 DSCAM GPHN KANK2 MCPH1 NTAQ1 RTN3 TRIM14 TTC33 ZFYVE19 ZNF655	14 interacting genes: CHMP3 DOCK8 E2F4 EIF2B5 MITD1 NOL4 SNCA STAMBP TGFB3 UFD1 USP54 USP8 VPS4A VPS4B
Entrez ID		129531	27243
HPRD ID		14044	12520
Ensembl ID		ENSG00000158411	ENSG00000130724
Uniprot IDs		Q8WV92	M0R1T5 O43633
PDB IDs		2YMB 4A5X 4A5Z	7ZCG 7ZCH
Enriched GO Terms of Interacting Partners?		Mitotic Cytokinetic Process Midbody Abscission ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole ESCRT III Complex Disassembly ESCRT Complex Disassembly Cytokinetic Process Multivesicular Body-lysosome Fusion Viral Budding From Plasma Membrane Lysosomal Membrane Organization Regulation Of Centrosome Cycle Late Endosome To Lysosome Transport Kinetochore Microtubule Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Viral Budding Nuclear Membrane Reassembly Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Assembly Multivesicular Body Organization Regulation Of Spindle Assembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Organization Membrane Fission Multivesicular Body Mitotic Metaphase Chromosome Alignment Multivesicular Body Sorting Pathway Regulation Of Centrosome Duplication Nuclear Membrane Organization Autophagosome Maturation Regulation Of Cell Cycle Process Regulation Of Cell Cycle Autophagosome Membrane Metaphase Chromosome Alignment Membrane Assembly Midbody Chromosome Localization Endosome Organization Nuclear Pore Nucleus Organization Vesicle Fusion Organelle Membrane Fusion Regulation Of Microtubule-based Process Plasma Membrane Organization Lysosomal Transport	Mitotic Cytokinetic Process Viral Budding Viral Budding Via Host ESCRT Complex Midbody Abscission Cytokinetic Process Multivesicular Body Sorting Pathway Viral Budding From Plasma Membrane K63-linked Deubiquitinase Activity Late Endosome To Lysosome Transport Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Late Endosomal Microautophagy Regulation Of Exosomal Secretion Midbody Endosome Organization Nuclear Membrane Reassembly Cytoskeleton-dependent Cytokinesis Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Assembly Multivesicular Body Organization Late Endosome To Vacuole Transport Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Mitotic Metaphase Chromosome Alignment Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Nuclear Membrane Organization Autophagosome Maturation Viral Process Late Endosome Membrane Positive Regulation Of Secretion Biological Process Involved In Interaction With Host Endosome To Lysosome Transport Metaphase Chromosome Alignment Membrane Assembly ESCRT III Complex Disassembly ESCRT Complex Disassembly Mitotic Cytokinesis ATPase Complex Regulation Of Exocytosis Regulation Of Secretion Chromosome Localization Positive Regulation Of Exocytosis Positive Regulation Of Exosomal Secretion Nuclear Pore Protein Domain Specific Binding Cysteine-type Deubiquitinase Activity Nucleus Organization Protein Deubiquitination
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