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C22orf39 and GNE
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
C22orf39
GNE
Description
chromosome 22 open reading frame 39
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Mitochondrion
Synaptic Cleft
Synapse
Cytoplasm
Cytosol
Molecular Function
Protein Binding
Nucleotide Binding
Catalytic Activity
Hydrolase Activity, Hydrolyzing O-glycosyl Compounds
Protein Binding
ATP Binding
UDP-N-acetylglucosamine 2-epimerase Activity
N-acylmannosamine Kinase Activity
Kinase Activity
Transferase Activity
Hydrolase Activity
Metal Ion Binding
Biological Process
Regulation Of Synaptic Plasticity
Negative Regulation Of Long-term Synaptic Potentiation
N-acetylglucosamine Biosynthetic Process
UDP-N-acetylglucosamine Metabolic Process
N-acetylneuraminate Metabolic Process
CMP-N-acetylneuraminate Biosynthetic Process
N-acetylneuraminate Biosynthetic Process
Carbohydrate Phosphorylation
Glycosylation
Pathways
Sialic acid metabolism
Defective GNE causes sialuria, NK and IBM2
Drugs
Diseases
Sialuria/ Sialic acid storage disease, including: Infantile sialic acid storage disease (ISSD); Sialuria, Finnish type / Salla disease (SD); Sialuria, French type
Nonaka distal myopathy (NM); Distal myopathy with rimmed vacuoles (DMRV); Hereditary inclusion body myopathy (hIBM)
Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
GWAS
Bipolar disorder (inflammation and infection response interaction) (
25781172
)
Bisphosphonate-associated atypical femoral fracture (
31006051
)
Interacting Genes
42 interacting genes:
ANKS1A
BANP
CABP2
CEP76
COL8A1
CRYBA2
CYSRT1
DTX2
EXOSC8
FRS3
GNE
GRN
HSD3B7
ID2
ID3
INCA1
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-8
KRTAP10-9
KRTAP12-3
KRTAP13-2
KRTAP9-2
MAGEA11
MAPK8IP2
MDFI
MGAT5B
NFATC2IP
PCSK5
PFDN5
PLSCR3
PPP2CB
PSMA1
RBPMS
RECK
RIMBP3C
SNX32
SYCE1L
TRIB3
VWC2L
ZNF620
65 interacting genes:
ADAMTSL4
C22orf39
CFP
CRMP1
CYSRT1
ECM1
EGFL7
GRN
GTPBP3
HOXA1
KIAA1549
KPRP
KRT31
KRT34
KRT40
KRT83
KRT85
KRT86
KRTAP1-1
KRTAP1-3
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-3
KRTAP13-2
KRTAP13-3
KRTAP17-1
KRTAP19-2
KRTAP19-7
KRTAP3-1
KRTAP3-3
KRTAP4-1
KRTAP4-11
KRTAP4-12
KRTAP4-4
KRTAP5-9
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP9-2
KRTAP9-3
KRTAP9-8
MDFI
MGAT5B
NBPF19
NID2
NOTCH2NLA
PLA2G10
PRICKLE4
RIF1
SPRY1
SPRY2
SPRY3
SSC4D
TRIM27
TRIM42
TRIP6
TSPAN4
VWC2
WDR83
WWOX
ZBTB16
Entrez ID
128977
10020
HPRD ID
14041
04825
Ensembl ID
ENSG00000242259
ENSG00000159921
Uniprot IDs
Q6P5X5
A0A7I2SU25
Q9Y223
PDB IDs
2YHW
2YHY
2YI1
3EO3
4ZHT
Enriched GO Terms of Interacting Partners
?
Keratin Filament
Intermediate Filament
Intermediate Filament
Keratin Filament
Structural Constituent Of Skin Epidermis
Cytosol
Hair Cycle
Keratinization
Intermediate Filament Organization
Structural Molecule Activity
Epidermis Development
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Negative Regulation Of Lens Fiber Cell Differentiation
Negative Regulation Of Ras Protein Signal Transduction
Protein Binding
Identical Protein Binding
Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Bud Elongation Involved In Lung Branching
Interstitial Matrix
Regulation Of Lens Fiber Cell Differentiation
Regulation Of Ras Protein Signal Transduction
Regulation Of Neurotrophin TRK Receptor Signaling Pathway
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Tagcloud (Difference)
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Tagcloud (Intersection)
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