P4HB and FNDC3B

Number of citations of the paper that reports this interaction (PubMedID 36811957)
49

Data Source:
BioGRID (unspecified method)

		P4HB	FNDC3B
Description		prolyl 4-hydroxylase subunit beta	fibronectin type III domain containing 3B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Cytoskeleton Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Procollagen-proline 4-dioxygenase Complex Lamellipodium Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Exosome	Cytoplasm Endomembrane System Membrane
	Molecular Function	RNA Binding Protein Disulfide Isomerase Activity Actin Binding Procollagen-proline 4-dioxygenase Activity Integrin Binding Protein Binding Protein-disulfide Reductase Activity Isomerase Activity Thiol Oxidase Activity Enzyme Binding Protein-containing Complex Binding Protein Heterodimerization Activity	RNA Binding Protein Binding
	Biological Process	Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Insulin Processing Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Viral Entry Into Host Cell Cellular Response To Hypoxia Cellular Response To Interleukin-7 Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of T Cell Migration
Pathways		Collagen biosynthesis and modifying enzymes Insulin processing Detoxification of Reactive Oxygen Species Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Hedgehog ligand biogenesis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly LDL remodeling Interleukin-12 signaling Interleukin-23 signaling
Drugs		Zinc Ribostamycin Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Appendicular lean mass ( 33097823) Bell's palsy ( 33602968) Central corneal thickness ( 29760442 30894546 31798171 32528159) Corneal hysteresis ( 30894546) Corneal resistance factor ( 30894546 31246245) Corneal structure ( 23291589) Coronary artery disease ( 33020668 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma (primary open-angle) ( 33627673) Glycated hemoglobin levels ( 34059833 28898252) Heart rate ( 23583979) Height ( 31562340 33713608 23563607 28552196 25282103 25429064) Hip circumference adjusted for BMI ( 28552196 34021172 25673412) Hypertrophic cardiomyopathy ( 33495597 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Immature fraction of reticulocytes ( 32888494 27863252) Intraocular pressure ( 25173106 31798171 28073927 29785010 30054594 29617998 29235454) Intraocular pressure (Goldman correlated) ( 30894546) Keratoconus ( 33649486) Mean corpuscular hemoglobin ( 32888494) Myocardial infarction ( 33532862) Parkinson's disease ( 26227905) PR interval ( 32439900) Pulse pressure ( 30224653) Red cell distribution width ( 32888494 27863252 28957414) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triptolide cytotoxicity ( 26121980) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		54 interacting genes: CD1D CHCHD2 CNNM3 COL10A1 COL1A1 COL1A2 CSNK2A2 CST2 EIF2S1 ENO1 ERN1 ERO1A ERO1B ESR1 FAM20C FEZ1 FNDC3B FZD10 GARIN6 GRN HNRNPD ITGB3 KLHL42 KRTAP12-3 KRTAP13-2 KRTAP4-11 KRTAP5-9 KRTAP6-3 KRTAP9-8 LCE1B LCE2D LCE4A LCN2 LGALS9 LINC00839 LRFN4 NECTIN2 NOL4 NTM ODF1 OGT P4HA2 P4HA3 PDE4B PLCXD3 PRNP PTN SUMO2 TG TGFB1 UBQLN1 VWF YWHAG ZNF69	124 interacting genes: ABHD11 ABHD8 ACTG1 ACTMAP ADGRF5 AHNAK ALB ANXA2 ATP1A1 ATP5F1A BBS2 BICRAL BRWD1 C10orf55 C22orf15 CAMK2D CAP1 CAPN3 CDC42 CEMP1 CFL1 DAPL1 DSTN DUSP10 EEF1E1 EGFR EIF5A2 ENO1 ERCC6 ERH ERI3 FUS GAS2L3 GOLT1B GTF2F1 HAPLN2 HNRNPD HNRNPK HSP90AB4P HSPA1A HSPA5 HSPA7 HSPA8 HSPB1 HSPD1 HSPH1 KARS1 KLHDC7B KRTAP11-1 L3MBTL3 LARP4 MBD3L1 MBOAT7 MCCD1 MVP MYH14 MYL6 NAGK NCAM2 NCK1 NDUFAB1 P4HB PARP1 PC PGK1 PIK3R4 PKLR POGZ POU6F2 PPP6R2 PRKAA2 PSMA3 PTMA RAB1A RAB1B RAN REL RPL12 RPL15 RPL17 RPL23 RPL28 RPL34 RPS14 RPS3 RPS3A RPS6 RUSC1 SNRPD3 SOD1 SPCS2 SPMIP10 SPMIP5 SPSB2 SRARP STPG4 SUGT1 SUOX SYNCRIP TEKT5 TEPSIN TESMIN TEX48 TGM2 TIAM1 TKT TOX4 TPM3 TRAF2 TRIM16 TRIM35 TRIM42 TRIP13 TTN TUBB4A TUBGCP6 TXN UBA52 UBAP2 USP54 VAC14 YPEL3 YWHAZ ZMYND19
Entrez ID		5034	64778
HPRD ID		07181	10943
Ensembl ID		ENSG00000185624	ENSG00000075420
Uniprot IDs		A0A024R8S5 P07237	Q53EP0
PDB IDs		1BJX 1MEK 1X5C 2BJX 2K18 3BJ5 3UEM 4EKZ 4EL1 4JU5 6I7S 7ZSC 8EOJ 8GDY
Enriched GO Terms of Interacting Partners?		Protease Binding Identical Protein Binding Endoplasmic Reticulum Lumen Collagen Type I Trimer Intermediate Filament Cellular Response To Oxygen-containing Compound Protein Binding Extracellular Space Collagen Fibril Organization Cellular Response To Glucose Stimulus Response To Amino Acid Response To Monosaccharide Tissue Development Response To Kainic Acid Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Keratinization Cellular Response To Carbohydrate Stimulus Procollagen-proline 4-dioxygenase Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Response To Tumor Cell Extracellular Matrix Organization Extracellular Structure Organization Response To Oxidative Stress Thiol Oxidase Activity Response To Carbohydrate Intracellular Glucose Homeostasis Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Proteolysis Odontoblast Differentiation Biomineral Tissue Development Keratin Filament Extracellular Matrix Structural Constituent Conferring Tensile Strength Regulation Of Leukocyte Mediated Cytotoxicity Cellular Response To Growth Factor Stimulus Negative Regulation Of Innate Immune Response Regulation Of Monoatomic Ion Transmembrane Transport Response To Xenobiotic Stimulus Fibrillar Collagen Trimer Positive Regulation Of Axon Regeneration Regulation Of Endothelial Cell Migration Regulation Of Lymphocyte Mediated Immunity Carbohydrate Homeostasis Response To Estradiol Glucose Homeostasis Negative Regulation Of Translational Initiation Negative Regulation Of Leukocyte Activation Regulation Of Innate Immune Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Growth Factor Positive Regulation Of Proteolysis	Extracellular Exosome Cytosol Cytoplasm Cytoplasmic Translation Cytosolic Ribosome Focal Adhesion Ribonucleoprotein Complex RNA Binding ATP-dependent Protein Folding Chaperone Translation Structural Constituent Of Ribosome Ribosome Protein Refolding Cadherin Binding Cytosolic Large Ribosomal Subunit Protein-containing Complex Melanosome Protein Binding Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding ATP Metabolic Process Protein Metabolic Process Protein Phosphatase Binding Cytosolic Small Ribosomal Subunit Regulation Of Intrinsic Apoptotic Signaling Pathway Protein-folding Chaperone Binding Nucleotide Binding Response To Nitric Oxide Protein Folding Positive Regulation Of Protein Metabolic Process Organophosphate Metabolic Process Enzyme Binding Actin Filament-based Process Macromolecule Metabolic Process Nucleotide Metabolic Process Nucleus Vesicle Structural Molecule Activity Conferring Elasticity Purine Nucleotide Metabolic Process Protein Folding Chaperone Nucleobase-containing Small Molecule Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway ATP Binding Positive Regulation Of Gene Expression Nicotinamide Nucleotide Metabolic Process Unfolded Protein Binding Nucleoside Phosphate Metabolic Process Cellular Response To Nitric Oxide
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