P4HB and CD1D

Number of citations of the paper that reports this interaction (PubMedID 11257307)
0

Data Source:
HPRD (in vitro)

		P4HB	CD1D
Description		prolyl 4-hydroxylase subunit beta	CD1d molecule
Image
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Cytoskeleton Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Procollagen-proline 4-dioxygenase Complex Lamellipodium Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Exosome	Extracellular Space Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	RNA Binding Protein Disulfide Isomerase Activity Actin Binding Procollagen-proline 4-dioxygenase Activity Integrin Binding Protein Binding Protein-disulfide Reductase Activity Isomerase Activity Thiol Oxidase Activity Enzyme Binding Protein-containing Complex Binding Protein Heterodimerization Activity	Protein Binding Beta-2-microglobulin Binding Lipid Antigen Binding Endogenous Lipid Antigen Binding Exogenous Lipid Antigen Binding Cell Adhesion Molecule Binding Lipopeptide Binding
	Biological Process	Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Insulin Processing Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Viral Entry Into Host Cell Cellular Response To Hypoxia Cellular Response To Interleukin-7 Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of T Cell Migration	Positive Regulation Of T Cell Mediated Cytotoxicity Immune System Process Immune Response Detection Of Bacterium Heterotypic Cell-cell Adhesion Positive Regulation Of T Cell Proliferation T Cell Selection Innate Immune Response Positive Regulation Of Innate Immune Response Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib
Pathways		Collagen biosynthesis and modifying enzymes Insulin processing Detoxification of Reactive Oxygen Species Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Hedgehog ligand biogenesis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly LDL remodeling Interleukin-12 signaling Interleukin-23 signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Zinc Ribostamycin Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form	cis-tetracosenoyl sulfatide
Diseases
GWAS			Dental caries (decayed and filled deciduous teeth) ( 31533690)
Interacting Genes		54 interacting genes: CD1D CHCHD2 CNNM3 COL10A1 COL1A1 COL1A2 CSNK2A2 CST2 EIF2S1 ENO1 ERN1 ERO1A ERO1B ESR1 FAM20C FEZ1 FNDC3B FZD10 GARIN6 GRN HNRNPD ITGB3 KLHL42 KRTAP12-3 KRTAP13-2 KRTAP4-11 KRTAP5-9 KRTAP6-3 KRTAP9-8 LCE1B LCE2D LCE4A LCN2 LGALS9 LINC00839 LRFN4 NECTIN2 NOL4 NTM ODF1 OGT P4HA2 P4HA3 PDE4B PLCXD3 PRNP PTN SUMO2 TG TGFB1 UBQLN1 VWF YWHAG ZNF69	7 interacting genes: B2M CALR CANX CD74 P4HB PTPRC TRB
Entrez ID		5034	912
HPRD ID		07181	01780
Ensembl ID		ENSG00000185624	ENSG00000158473
Uniprot IDs		A0A024R8S5 P07237	A0A669KAZ2 A0A669KB34 P15813
PDB IDs		1BJX 1MEK 1X5C 2BJX 2K18 3BJ5 3UEM 4EKZ 4EL1 4JU5 6I7S 7ZSC 8EOJ 8GDY	1ZT4 2PO6 3HUJ 3SDX 3TZV 3U0P 3VWJ 3VWK 4EN3 4LHU 4MNG 4MQ7 4WO4 4WW2 4WWK 6V7Y 6V7Z 6V80 8SGB 8SGM 8SOS
Enriched GO Terms of Interacting Partners?		Protease Binding Identical Protein Binding Endoplasmic Reticulum Lumen Collagen Type I Trimer Intermediate Filament Cellular Response To Oxygen-containing Compound Protein Binding Extracellular Space Collagen Fibril Organization Cellular Response To Glucose Stimulus Response To Amino Acid Response To Monosaccharide Tissue Development Response To Kainic Acid Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Keratinization Cellular Response To Carbohydrate Stimulus Procollagen-proline 4-dioxygenase Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Response To Tumor Cell Extracellular Matrix Organization Extracellular Structure Organization Response To Oxidative Stress Thiol Oxidase Activity Response To Carbohydrate Intracellular Glucose Homeostasis Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Proteolysis Odontoblast Differentiation Biomineral Tissue Development Keratin Filament Extracellular Matrix Structural Constituent Conferring Tensile Strength Regulation Of Leukocyte Mediated Cytotoxicity Cellular Response To Growth Factor Stimulus Negative Regulation Of Innate Immune Response Regulation Of Monoatomic Ion Transmembrane Transport Response To Xenobiotic Stimulus Fibrillar Collagen Trimer Positive Regulation Of Axon Regeneration Regulation Of Endothelial Cell Migration Regulation Of Lymphocyte Mediated Immunity Carbohydrate Homeostasis Response To Estradiol Glucose Homeostasis Negative Regulation Of Translational Initiation Negative Regulation Of Leukocyte Activation Regulation Of Innate Immune Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Growth Factor Positive Regulation Of Proteolysis	Protein Folding Protein Folding In Endoplasmic Reticulum Endoplasmic Reticulum Lumen External Side Of Plasma Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Positive Regulation Of Endocytosis Positive Regulation Of Cell Adhesion Extracellular Exosome MHC Class I Peptide Loading Complex Regulation Of Endocytosis Peptide Antigen Assembly With MHC Class I Protein Complex Endoplasmic Reticulum Regulation Of Cell Adhesion Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Thymic T Cell Selection Negative Thymic T Cell Selection Regulation Of Immune System Process Negative T Cell Selection Lymphocyte Mediated Immunity Positive T Cell Selection Positive Regulation Of Viral Entry Into Host Cell MHC Class II Protein Complex Focal Adhesion Heparan Sulfate Proteoglycan Binding Regulation Of Cell Migration Endocytic Vesicle Lumen T Cell Mediated Cytotoxicity Leukocyte Mediated Immunity Regulation Of Cell Motility Positive Regulation Of Immune System Process Positive Regulation Of Leukocyte Migration Regulation Of Viral Entry Into Host Cell Thymic T Cell Selection Regulation Of Locomotion Response To Stress Protein Transport Endoplasmic Reticulum Quality Control Compartment Positive Regulation Of Viral Life Cycle MHC Class II Protein Complex Binding Regulation Of Vesicle-mediated Transport Negative Regulation Of Multicellular Organismal Process Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Migration Antigen Processing And Presentation Of Endogenous Antigen T Cell Selection Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
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